Medical PG Pathology
1. Programmed cell death is also called as :
(A) Apoptosis
(B) Necrosis
(C) Degeneration
(D) Calcification
2. Haemorrhagic infarct may be seen in :
(A) Brain
(B) Lung
(C) Spleen
(D) Heart
3. All of the following constitute familial cancer syndrome except :
(A) Xeroderma-pigmentosum
(B) Retinoblastoma
(C) Neurofibromatosis
(D) MEN-I
4. Howel-Jolly bodies may be seen after :
(A) Hepatectomy
(B) Splenectomy
(C) Pancreatectomy
(D) Cholecystectomy
5. ‘Intermediate form’ of Non hodgkin’s lymphoma is :
(A) Small noncleaved cell
(B) Diffuse, small cleaved cell
(C) Lymphoblastic
(D) Large cell immunoblastic
6. ‘Hairy cell leukemia’ is a neoplastic proliferation of :
(A) T.cells
(B) B. cells
(C) Myeloid cells
(D) Macrophages
7. Characteristic feature of Rheumatic carditis is :
(A) Pericarditis
(B) Endocarditis
(C) Myocarditis
(D) Pancrditis
8. Most common tumour of heart is :
(A) Myxoma
(B) Rhabdomyosarcoma
(C) Fibroma
(D) Leiomyosarcoma
9. Almost always associated with one of the following conditions :
(A) Diabetes-mellitus
(B) Analgesic-nephropathy
(C) Chronic pyelonephirits
(D) Post streptococcal GN
10. Which of the following types of glomerulonephiritis is most likely to cause CRF all except
(A) Post streptococcal glomerulonephritis
(B) Membranous GN
(C) Membrano proliferative GN
(D) Focal segmental glomerulosclerosis
11. In Leprosy most common renal lesion seen is :
(A) MGN
(B) MPGN
(C) Focal glomeruloselerosis
(D) Diffuse glomerulosclerosis
12. Centrilobular necrosis of liver may be seen with :
(A) Phosphorus
(B) Arsenic
(C) CCl₄
(D) Ethanol
13. Kaposi sarcoma associated with gut may be seen in
(A) Nonhodgkin’s lymphoma
(B) HIV-infection
(C) Fungal infection
(D) Keratoacanthosis
14. Most common histological types of lung carcinoma in India is:
(A) Squamous cell CA
(B)Adeno carcinoma
(C) Small cell CA
(D) Large cell CA
15. Which of the following histological type lung carcinoma has worst prognosis :
(A) Squamous cell CA
(B) Adenocarcinoma
(C) Alveolar-carcinoma
(D) Small cell carcinoma
16. Characteristic pathological feature of Parkinson’s disease is presence of :
(A) Lewy bodies
(B) Babes nodule
(C) Neuro fibrillary tangle
(D) Negri-bodies
17. Pathological manifestation of chronic alcoholism include all of the following except :
(A) Piecemeal necrosis
(B) Balloning degeneration
(C) Microvesicular fatty changes
(D) Central hyaline sclerosis
18. Pale infract is not seen in
(A) Heart
(B) Lung
(C) Kidney
(D) Spleen
19. In an inflammatory response, Macrophages are usually derived from
(A) Monocytes
(B) Reticuloendothelial cells
(C) Neutrophils
(D) Lymphocytes
20. Heart failure cells contain
(A) Hemosiderin
(B) Lipofuschin
(C) Myoglobin
(D) Albumin
21. The most common site of Myocardial infarction is
(A) Anterolateral
(B) Interventricular septum
(C) Posterior wall
(D) Inferior wall
22. Most common cause of Abdominal aorta aneurysm is
(A) Atherosclerosis
(B) Trauma
(C) Marfan’s syndrome
(D) Congenital
23. Commonest cause of SVC obstruction is
(A) Fibrosis of SVC
(B) Bronchogenic carcinoma
(C) Pericardial fibrosis
(D) hepatocellular carcinoma
24. The cells seen after 72 hours in the Infracted area in MI are
(A) Neutrophils
(B) Lymphocytes
(C) Macrophages
(D) Monocytes
25. The least common site of Berry aneurysm is
(A) Anterior communicating artery
(B) Vertebral artery
(C) Basilar artery
(D) Middle cerebral artery
26. The commonest tumor of the myocardium is
(A) Myxoma
(B) Rhabdomyoma
(C) Sarcoma
(D) Fibroma
27. All of the following decrease in Nephrotic syndrome except
(A) Fibrinogen
(B) Thyroxin
(C) Transferrin
(D) Albumin
28. All are features of RPGN except
(A) Rapid recovery
(B) Crescent formation
(C) Hypertension
(D) Non-selective proteinuria
29. Which characteristic feature is seen in the kidney in Malignant hypertension
(A) Hyaline necrosis
(B) Fibrinoid necrosis
(C) Medial wall hyperplasia
(D) Micro-aneurysm
30. Most common factor in development of Diabetic nephropathy is
(A) Previous kidney disease
(B) Associated hypertension
(C) Duration of diabetes
(D) Control with treatment
31. The HLA important in IDDM is
(A) HLA-A₃
(B) HLA-B₂₇
(C) HLA-DR₃/DR₄
(D) HLA-W₁
32. The commonest Soft tissue tumor in adults is
(A) Lipoma
(B) Histiocytoma
(C) Fibroma
(D) Leiomyoma
33. Malignancy of the Breast is likely to be associated with
(A) Sclerosing adenosis
(B) Atypical epithelial hyperplasia
(C) Cystic change
(D) Apocrine metaplasia
34. All of the following Paraneoplastic syndromes are seen in Carcinoma lung except
(A) Hypertrophic osteodystrophy
(B) Myasthenia gravis
(C) Cushing’s syndrome
(D) Hypoglycemia
35. The commonest site of Pleomorphic adenoma is
(A) Parotid salivary gland
(B) Submandibular salivary gland
(C) Sublingual gland
(D) Submaxillary gland
36. MEN type I includes tumors of all except
(A) Parathyroid
(B) Pituitary
(C) Pancreas
(D) Medullary carcinoma of thyroid
37. Primary pleural tumor is
(A) Mesothelioma
(B) Myxoma
(C) Lipoma
(D) Fibroma
38. Mucin is not secreted by
(A) Goblet cell
(B) Paneth cell
(C) Brunner’s gland
(D) Crypts of Lieberkuhn
39. Pseudopolyps are features of
(A) Crohn’s disease
(B) Ulcerative colitis
(C) Celiac sprue
(D) Whipple’s disease
40. Transport of lipids from the intestine to other tissues is by
(A) Chylomicrons
(B) LDL
(C) HDL
(D) VLDL
41. Dystrophic calcification is seen in
(A) Milk-alkali syndrome
(B) Atheromatous plaque
(C) Hyperparathyroidism
(D) Vitamin A intoxication
42. Cytokeratin is seen in
(A) Neurofibroma
(B) Lymphoma
(C) Carcinoma
(D) Fibrosarcoma
43. Pale infarct is not seen in
(A) Lung
(B) Liver
(C) Spleen
(D) Heart
44. Major fibril protein in Primary Amyloidosis is
(A) AL
(B) AA
(C) Transthyretin
(D) Procalcitonin
45. Laminin is found in the
(A) Outer nuclear membrane
(B) Inner nuclear membrane
(C) Basement membrane
(D) Endothelium
46. The most common cause of SVC syndrome is
(A) Thrombosis
(B) Extrinsic compression
(C) Mediastinal lymphoma
(D) Teratoma
47. In Marfan’s syndrome, Aortic aneurysm occurs most commonly in:
(A) Ascending aorta
(B) Descending aorta
(C) Abdominal aorta
(D) Arch of aorta
48. McCallum’s patch is diagnostic of
(A) Infective endocarditis
(B) Rheumatic endocarditis
(C) Myocardial infarction
(D) Tetralogy of Fallot(ToF)
49. Calcification of the aortic valve is seen in
(A) Aortic stenosis
(B) Aortic regurgitation
(C) Marfan’s syndrome
(D) Hurler’s syndrome
50. Which is a component of ToF
(A) Aorta arises from RV
(B) LVH
(C) VSD
(D) ASD
51. The following carcinomas are associated with DIC except
(A) Stomach
(B) Pancreas
(C) Pancreas
(D) Breast
52. The pathological change in malignant hypertension is
(A) Hyperplastic arteriosclerosis
(B) Cystic medial necrosis
(C) Benign nephrosclerosis
(D) Hyaline arteriosclerosis
53. All of the following may be involved in PAN except
(A) Kidney
(B) Heart
(C) Liver
(D) Lung
54. Pathological changes of diabetic nephropathy are all except
(A) Fibrin caps and capsular drops
(B) Intercapillary glomerulosclerosis
(C) Focal sclerosis
(D) Capillary basement membrane thickening
55. True about Light microscopic changes in Minimal Change Glomerulonephritis is
(A) No abnormality
(B) Fusion of foot process
(C) Absence of Immunoglobulins
(D) Absence of complement
56. The following are seen in chronic obstructive pulmonary disease(COPD) except
(A) Hemoptysis
(B) Cor Pulmonale
(C) Pneumothorax
(D) Aplastic anemia
57. Deficiency of the ‘intrinsic factor of Castle’ causes
(A) Megaloblastic anemia
(B) Pernicious anemia
(C) Cooley’s anemia
(D) Aplastic anemia
58. The most pre-cancerous condition for carcinoma colon is
(A) Familial polyposis
(B) Hamartomatous polyps
(C) Juvenile polyps
(D) Hyperplastic polyps
59. In Peutz-Jeghers syndrome, polyps are seen in
(A) Colon
(B) Rectum
(C) Small bowel
(D) Stomach
60. Which is NOT a component of Werner’s syndrome
(A) Pituitary
(B) Adrenal
(C) Parathyroid
(D) Pancreas
61. Malignancy in pheochromocytoma is indicated by
(A) Vascular invasion
(B) Mitotic figures
(C) Capsular invasion
(D) Metastasis
62. An Autosomal Dominant condition is
(A) Albinism
(B) Huntington’s chorea
(C) Hurler’s syndrome
(D) Hunter’s syndrome
63. Which is not a type III hypersensitivity reaction
(A) TB
(B) Rheumatoid arthritis
(C) SLE
(D) Arthus reaction
64. Russell’s body is found in
(A) WBC
(B) RBC
(C) Mast cell
(D) Plasma cell
65. The function of oligodendrocyte is
(A) Myelinates the CNS
(B) Nutrition of nervous tissue
(C) Lining the cavities of the CVS
(D) Behave like macrophages
66. Triple helix structure is found in
(A) Keratin
(B) Collagen
(C) Proline
(D) Cellulose
67. Function of Langerhans cells are
(A) Antigen presentation
(B) Phagocytosis
(C) Autoimmune
(D) None of the above
68. Russell bodies are found in
(A) Multiple Myeloma
(B) Gonadal tumor
(C) Parkinsonism
(D) Intracranial neoplasms
69. The correct statement regarding fat distribution in cold-water channel swimmers is
(A) Preferentially deposited in subcutaneous tissue
(B) Accumulated around the abdominal viscera
(C) Concentrated retroperitoneally
(D) Deposited preferentially in the liver
70. Macro-vesicular fatty liver is seen in
(A) Protein-Energy malnutrition
(B) Viral hepatitis
(C) Acute fatty liver of Pregnancy
(D) Reye’s syndrome
71. Vitamin K-dependent factor is
(A) II
(B) III
(C) IV
(D) VI
72. The most common pre-malignant condition of oral carcinoma is
(A) Leukoplakia
(B) Erythroplakia
(C) Lichen planus
(D) Fibrosis
73. The following are predisposing factors for Esophageal carcinoma except
(A) Plummer-Vinson syndrome
(B) Tylosis palmaris
(C) Chronic Achalasia
(D) Benzene therapy
74. Amongst the following, the most common site for Leiomyoma is
(A) Stomach
(B) Small Intestine
(C) Duodenum
(D) Colon
75. Skip granulomatous lesions are seen in
(A) Ulcerative colitis
(B) Crohn’s disease
(C) Whipple’s disease
(D) Reiter’s disease
76. Toxic megacolon is most commonly associated with
(A) Ulcerative colitis
(B) Crohn’s disease
(C) Whipple’s disease
(D) Reiter’s disease
77. Clinical features of minimal change glomerulonephritis are all except
(A) Hypertension
(B) Edema
(C) Selective proteinuria
(D) Fever
78. All are steroid resistant except
(A) Post-streptococcal glomerulonephritis
(B) Minimal change glomerulonephritis
(C) RPGN
(D) Recurrent hematuria
79. Post-infective glomerulonephritis present as
(A) ARF
(B) Nephrotic syndrome
(C) Nephritic syndrome
(D) Asymptomatic hematuria
80. An important factor for chronic pyelonephritis is
(A) Obstruction
(B) Vesico-ureteral reflux
(C) Pelvi-ureteric junction obstruction
(D) Catheter induced
81. Flea-bitten kidney is seen in all except
(A) SABE
(B) Malignant hypertension
(C) Hemolytic Uremic Syndrome
(D) Diabetic nephropathy
82. A testicular tumor marker is
(A) α-Fetoprotein
(B) Ectopic hormones
(C) CEA
(D) Testosterone
83. Which Hodgkin’s disease is associated with best prognosis
(A) Lymphocytic depletion
(B) Lymphocyte depletion
(C) Mixed cellularity
(D) Nodular sclerosis
84. Ectoptic ACTH production is seen in
(A) Small cell carcinoma is lung
(B) Anaplastic carcinoma of lung
(C) Squamous cell carcinoma of lung
(D) Adenocarcinoma of lung
85. The nucleus involved in Alzheimer’s disease is
(A) Basal nucleus of Mayernet
(B) Raphe nucleus
(C) Superior salivary nucleus
(D) Basal lobe of cerebellum
86. The most common site for myocardial infarction is
(A) Left atrium
(B) Left ventricle
(C) Right atrium
(D) Right ventricle
87. Coagulative necrosis may be seen in all of the following except :
(A) Myocardial infarction
(B) Thermal injury
(C) Tuberculosis
(D) Zenker’s degeneration necrosis
88. Dystrophic calcification is seen in :
(A) Atheromatous plaques
(B) Gastric mucosa
(C) Normal tissue
(D) Lung
89. Langerhans cells are :
(A) Antigen presenting cells
(B) Phagocytosing cells
(C) Autoimmune cells
(D) Cell in acute infection
90. Increased capillary permeability is caused by all of the following except :
(A) Anaphylatoxin
(B) 5 hydroxytryptamine
(C) Renin
(D) Histamines
91. Tumour positive for cytokeration are likely to be:
(A) Adenoma
(B) Melanoma
(C) Carcinoma
(D) Lipoma
92. Pale infarcts are seen at all of the following sites except :
(A) Heart
(B) Spleen
(C) Kidney
(D) Lung
93. All of the following statements are true for cell againg except :
(A) Enlargement of telomere
(B) ↓number of mitochondria
(C) Glycolysation of DNA
(D) Glycolysation of RNA
94. All of the following gases contribute to green house effect except :
(A) Ozone
(B) Methane
(C) N₂O
(D) Chloroflorocarbons
95. Most commonly employed stain for amyloidosis is :
(A) Congored with polarized light
(B) Congored with non polarized light
(C) Sudan black
(D) Giemsa staining
96. All of the following statements regarding amyloidosis are true except :
(A) Multiple myeloma – shows AL type deposits
(B) Secondary amyloidosis-shows AA type deposits
(C) Renal amyloidosis commonly presents with hypertension
(D) Renal amyloidosis commonly presents with mida proteinuria
97. All of the following are decreased in Nephrotic syndrome except :
(A) Transferrin
(B) Ceruloplasmin
(C) Albumin
(D) Fibrinogen
98. All of the following are causes of granular contracted kidney except :
(A) Benign nephrosclerosis
(B) Chronic pylonephritis
(C) Diabetes mellitus
(D) Chronic glomerulonephritis
99. Salt losing nephritis s a feature of :
(A) Interstitial nephritis
(B) Amyloidosis of kidney
(C) Post streptococcal GN
(D) PEM
100. Common pathological changes seen in kidney in benign hypertension are :
(A) Fibronoid necrosis
(B) Microaneurysm
(C) Hyaline arteriosclerosis
(D) Thining of walls
101. All of the following conditions may show Mallory Hyaline changes except :
(A) Wilson disease
(B) Indian childhood cirrhosis
(C) Primary biliary cirrhosis
(D) Hepatitis E
102. Liver biopsy is carried out at 8th intercostals space in order to :
(A) Prevent pleural damage
(B) Prevent lung injury
(C) Pass through hepatorenal pouch
(D) Pass through bare area of liver
103. Thick mucous coat is :
(A) Protective in ulcer patients
(B) Not protective in ulcer patients
(C) Easily destroyed by antacids
(D) Commonly associated with carcinomatous change
104. Protective epithelium :
(A) Has regenerative power
(B) Does not have regenerative power
(C) Does not shed off easily
(D) Bleeding is common
105. Most common carcinoma of breast is
(A) Intra-ductal carcinoma
(B) Colloid carcinoma
(C) Lobular carcinoma
(D) Sarcoma phylloides
106. Commonest type of lung carcinoma in nonsmokers is
(A) Squamous cell CA
(B) Small cell CA
(C) Adeno CA
(D) Alveolar cell CA
107. Diagnostic feature in rheumatic heart disease is
(A) Aschoff’s nodule
(B) Mc Callumn patch
(C) Bread & butter pericarditis
(D) Shaggy vegetation
108. Least common site for berry aneurysm is :
(A) Vertebral artery
(B) Basilar artery
(C) Junction of anterior cerebral artery and internal carotidartery
(D) Posterior cerebral artery
109. In Alzheimer’s diseases the likely site of lesion is the :
(A) Basal nucleus of Mayernet
(B) Pons
(C) Basal ganglia
(D) Partial lobes of cerebrum
110. ‘Biological membranes’ are characterized by all of the following :
(A) They are symmetric bileaflet structures
(B) Their constituent lipid and protein moities are held together by covalent interactions.
(C) They are rigid assemblies of protein, lipid and carbohydrates
(D) Their lipid moieties are amphipathic in nature
111. Hypertriglyceridemia is seen in :
(A) LDL receptor defect
(B) Dysbetalipoprotenemia
(C) Abetalipoproteinemia
(D) all of the above
112. Apoptotic bodies are :
(A) Clumped chromatin bodies
(B) Pyknotic nucleus without organelles
(C) Cell membrane bound with organelles
(D) No nucleus with organelles
113. Langerhan’s cells are :
(A) Phagocytic cells
(B) Antigen presenting cells
(C) Seen in auto immune conditions
(D) Seen in chronic infection
114. Gittre cells are synonymous with :
(A) Ependymal cells
(B) Oligodendrocytes
(C) Astrocytes
(D) Modified CNS macrophages
115. Phagocytosis is the function of :
(A) Astrocytes
(B) Oligodendrocytes
(C) Microglia
(D) Schawan cells
116. Epitheloid granuloma may be seen in all of the following conditions except :
(A) Sarcoidosis
(B) Tuberculosis
(C) Pneumocystic carini
(D) Hodgkin’s lymphoma
117. Triple helix is found in :
(A) Cystine
(B) Collagen
(C) Pectin
(D) DNA
118. “Tertiary hyperparathyroidism’ refers to :
(A) Primary hyperparathyroidism with decrease Ca⁺⁺level
(B) Secondary hyperparathyroidism following chief cell adenoma
(C) Secondary hyperparathyroidism following intestinal malabsorption
(D) Metastasis with normal phosphate level metastasis
119. Lack of leucocyte adhesion molecules (LAM) is associated with :
(A) Delayed closure of umblical cord
(B) Normal chemotaxis
(C) Compliment opsinization
(D) Neutropenia
120. Maximum malignant potential is in :
(A) Superficial naevus
(B) Epidermal naevus
(C) Junctional naevus
(D) Intradermis naevus
121. Most common cause of aortic aneurysm is :
(A) Syphilis
(B) Marfan’s syndrome
(C) Atherosclerosis
(D) Congenital
122. Most common site of myocardial infaction is :
(A) Anterior wall of left ventricle
(B) Posterior wall of left ventricle
(C) Posterior wall of right ventricle
(D) Inferior wall of left ventricle
123. Most common type of hodgkin’s lymphoma in India is :
(A) Nodular sclerosing
(B) Lymphocyte predominance
(C) Mixed cellularity
(D) Lymphocyte depletion
124. Most malignant form of NHL is :
(A) Diffuse large cell
(B) Small cell lymphocytic lymphoma
(C) Follicular cleavage
(D) Large cell follicular
125. Fibrous histiocytoma is classified as :
(A) Haemangio pericytoma
(B) Sclerosing haemangioma
(C) Angiomyolipoma’s
(D) Angiomyosarcoma
126. Commonest site of lytic lesion in multiple myeloma is :
(A) Vertebral column
(B) Femur
(C) Clavicle
(D) Pelvis
127. Most common site of Leomyoma is :
(A) Stomach
(B) Ileum
(C) Colon
(D) Rectum
128. Common site of regional enteritis is :
(A) Colon
(B) Rectum
(C) Distal ileum and colon
(D) Caecum
129. Toxic megacolon is seen in :
(A) Chronic nonspecific ulcerative colititis
(B) Crohn’s disease
(C) Colonic diverticulosis
(D) Hamartomatous polyp
130. The pathological appearance in pseudomembranous colitis consists of :
(A) Necrosis and gangrene
(B) Small ulceration with slough
(C) Serositis with covered by membrane
(D) Excessive ulceration in serosa
131. Maximum endocapillary proliferation is a feature of :
(A) Membranous GN
(B) Measangio proliferation GN
(C) Focal sclerosis
(D) Post streptococcai GN
132. ‘Flea bitten’ appearance of kidney may be seen in all except :
(A) Malignant hypertension
(B) SABE
(C) Diabetes mellitus
(D) PAN
133. Most common pathological features in diabetes melitus is :
(A) Papillary necrosis
(B) Diffuse glomerulosclerosing
(C) Renal atherosclerosis
(D) Chronic pyelonephritis
134. Differentiating point between invasive carcinoma and carcinoma is situ is:
(A) Mitosis
(B) Penetration of basement membrane
(C) Cellular atypia
(D) Nuclear pleomorphism
135. Amyloidosis is found in the following except:
(A) Multiple myeloma
(B) Hypernephroma
(C) Thymoma
(D) Lymphoma
136. In DIC, following are seen except:
(A) Fibrinogen decreased
(B) Thrombocytopenia
(C) Normal APTT
(D) PT elevation
137. Pathological change in brain in cerebral malaria is:
(A) Cerebral edema
(B) Microvascular occlusion
(C) ICT
(D) Space occupying lesion
138. Pulmonary infarction and pulmonary edema is differentiated by
(A) Heart failure cells
(B) Necrotising alveolar sac
(C) Capillary congestion
(D) Pulmonary wedge pressure
139. Macrophage, granuloma erythrophagocytosis are found in:
(A) Ulcerative colitis
(B) Necrotising enterocolitis
(C) Regional ileitis
(D) Typhoid
140. Massive transfusion causes the following except:
(A) DIC
(B) Hypothermia
(C) Hypokalemia
(D) Hyperkalemia
141. Reed sternberg cells are found in:
(A) Hodgkin’s disease
(B) Sickle cell anaemia
(C) Thalassemia
(D) CML
142. Broad cast is characteristic of:
(A) CRF
(B) Ac GN
(C) ARF
(D) Renal TB
143. In rabies pathological lesions in CNS are
(A) Brainstem encephalitis
(B) Cranial nerve arteritis
(C) Neuronal loss
(D) Neurofibrillary tangles
144. Hemophilia manifest clinically as rise in
(A) APTT
(B) PT
(C) CT
(D) FDP
145. In malignant HTN, seen is:
(A) Hyalinised arterioles
(B) Replacement by necrotizing arteriolitis
(C) Calcification
(D) Atherosclerosis
146. True about integrin is
(A) Used in binding
(B) Oncogene
(C) Anti oncogene
(D) Component of basement membrane
147. Sezary syndrome included in category of
(A) T cell leukaemia
(B) Lymphoma
(C) B cell leukaemia
(D) Pigmented disorder of skin
148. Non specific esterase in present in :
(A) Megakaryocytic leukaemia
(B) Lymphocytic leukaemia
(C) Erythroleukaemia
(D) AML
149. Starting point of apoptosis for programme cell death is:
(A) Activation of endonuclease
(B) Release of enzyme
(C) Accumulation of calcium
(D) Destruction by macrophages
150. Lead causes following except :
(A) Uroporphyrinuria
(B) Sideroblastic anemia
(C) Basophilic stippling
(D) Macrocytic anemia
151. Coomb’s positive hemolysis is seen in:
(A) TTP
(B) SLE
(C) ITP
(D) PNH
152. In IgA nephropathy (Berger’s disease, there are:
(A) Subepithelial deposits
(B) Subendothelial deposits
(C) Mesangial deposits
(D) Basement membrane deposits
153. The cause of scleritis is:
(A) Collagen vascular disease
(B) TB
(C) Trauma
(D) Glaucoma
154. Delayed type of hypersensitivity is seen in following except:
(A) Arthus phenomenon
(B) Contact dermatitis
(C) Tuberculin test
(D) Graft vs host reaction
155. In shock, characteristic feature is:
(A) Cardiac failure
(B) Poor perfusion of tissues
(C) Cyanosis
(D) Oedema
156. Histiocytosis X is seen in except :
(A) Hand schuller Christian disease
(B) Eosinophilic granuloma
(C) Letter-siwe syndrome
(D) Torres syndrome
157. Defect leading to thalassemia lies in
(A) Haemoglobin
(B) Osmotic fragility
(C) RBC membrane
(D) Platelets
158. Hereditary spherocytosis is due to:
(A) Spectrin deficiency
(B) Integrin defect
(C) Collagen defect
(D) Defect with glycoprotein
159. Palpable purpura is seen in following except:
(A) ITP
(B) Henoch schonlein purpura
(C) Wegener’s granulomatosis
(D) Mixed cryoglobulinemia
160. Subepithelial deposits are seen in:
(A) Membranoproliferative nephropathy
(B) Membranous GN
(C) Minimal change GN
(D) Diabetic sclerosis
161. Antinuclear antibody specific for SLE is
(A) Anti ds DNA
(B) Anti nuclear antibodies
(C) Anti centromere antibody
(D) Anti histone Ab
162. Dystrophic calcification means:
(A) Calcification in destroyed tissue with normal calcium level in blood
(B) ↑ level of Ca⁺⁺ deposits
(C) Calcification in normal tissues seen in hyperparathyroidism
(D) Calcification is destroyed tissues with hyper calcemia
163. Psammoma bodies are seen in :
(A) Thyroid carcinoma
(B) Carcinoma breast
(C) Carcinoma stomach
(D) Carcinoma testis
164. In an adult Unilateral smooth contracted kidney with hypertension is seen in:
(A) Stenosis of renal artery
(B) Chr. GN
(C) Renal cell CA
(D) Pyelonephritis
165. Non immune hemolytic anemia occurs in:
(A) SLE
(B) P. vivax infection
(C) CLL
(D) CML
166. Following are the findings in sickle cell Amemia, except :
(A) Fish vertebra
(B) Enlarged heart
(C) Splenomegaly usually seen
(D) Leukocytosis
167. True about Thrombocytopenic pupura is :
(A) Haemolysis is extravasular
(B) Normal renal function test
(C) Thrombosis in cerebral blood vessels
(D) Immediate cure following plasmapheresis
168. In sickle cell trait, number of bands found in Hb:
(A) 2
(B) 1
(C) 4
(D) 5
169. Following injury to a blood vessel, immediate haemostasis is achieved by :
(A) Fibrin deposition
(B) Vasoconstriction
(C) Platelet adhesion
(D) Thrombosis
170. Lipoprotein X is elevated in:
(A) Primary biliary cirrhosis
(B) Indian childhood cirrhosis
(C) Hyper cholesterolemia
(D) Alcoholic cirrhosis
171. Isolation of cell molecules is done by:
(A) Centrifugation
(B) Selective separation
(C) Plasmin
(D) Fibrinogen precipitate
172. Morphologically diagnostic feature of cancer cells:
(A) ↑ Size
(B) ↑ Mitotic activity
(C) ↑ Cytoplasm
(D) ↑ Lysosomes
173. How do you differentiate CA in situ from invasive CA :
(A) Penetration of Basement membrane
(B) Number of mitotic cells
(C) Metastasis
(D) Nuclear plemorphism
174. Mismatched transfusion perioperatively is indicated by:
(A) Excess bleeding
(B) Hypothermia
(C) Hyperthermia
(D) Tachycardia
175. AML is characterized by:
(A) Philadelphia chromosome
(B) Auer rods
(C) Hemolytic anemia
(D) Dohle bodies
176. Barr body is absent in:
(A) Klinefelter’s syndrome
(B) Turner’s syndrome
(C) Super female
(D) None
177. True about multiple myeloma except :
(A) ↑ Uric acid
(B) ↑ Urea
(C) ↑ Ca⁺⁺
(D) ↑ Alk. phosphatase
178. Primary role of T-Lymphocytes is:
(A) Antibody formation
(B) Delayed hypersensitivity
(C) Complement production
(D) All of the above
179. Fibroblast is derived from:
(A) Local mesenchyme
(B) Macrophage
(C) Endothelium
(D) Vessels
180. Blood storage in CPD-A result in A/E:
(A) ↑NH₃ in blood
(B) ↑2, 3 DPG
(C) Hyperkalemia
(D) Citrate toxicity
181. Cast is produced due to damage to:
(A) Nephron
(B) Tubule
(C) PCT
(D) DCT
182. Enzyme level in tissue injury is due to:
(A) Lysis of cells
(B) Enzyme secretion
(C) No inhibitor in serum
(D) All of the above
183. Massive transfusion in previous healthy adult male can cause hemorrhage due to :
(A) Increased tPA
(B) Dilutional thrombocytopenia
(C) Vitamin K deficiency
(D) Decreased fibrinogen
184. Curshmann’s crystals are seen in:
(A) Bronchial asthma
(B) Bronchiectasis
(C) Chronic bronchitis
(D) Wegners granulomatosis
185. Pleural effusion in cirrhosis all are true except :
(A) ↓ Pleural LDH serum LDH
(B) Protein 10g/L
(C) Gluc 80 mg
(D) S.G. below 1.012
186. Atherosclerosis initiation by fibroblast plaque is mediated by injury to:
(A) Smooth
(B) Media
(C) Adventitia
(D) Endothelium
187. Crescents are derived from:
(A) Epithelial cells + fibrin + macrophage
(B) Mesangium + fibrin + macrophage
(C) tubule + mesangiaum + fibrin
(D) Mesangiaum + fibrin
188. Concentric hypertrophy of left ventricle is seen in:
(A) Cong. bicuspid aortic valve
(B) MS
(C) AR
(D) HOCM
189. Spherocytosis of RBC’s is a common feature in :
(A) G-6P-D deficiency
(B) Sickle cell anemia
(C) CML
(D) All
190. CD4 lymphocyte is
(A) T. helper cell in peripheral circulation
(B) T. cytotoxic
(C) Precursor cell in bone marrow
(D) Any of the above
191. Which is not a finding in viral encephalitis :
(A) Astroglial proliferation
(B) Perivascular mononuclear infiltrate
(C) Inclusion bodies intranuclear and intracytoplasmic
(D) None of the above
192. Amyloid is found in
(A) Medullary carcinoma thyroid
(B) ALL
(C) Cirrhosis
(D) Budd chiari syndrome
193. Lacunar cells are seen in which type of Hodgkin’s lymphoma :
(A) Lymphocyte predominance
(B) Lyphocyte depletion
(C) Nodular sclerosing
(D) Mixed cellularity
194. Not true regarding waldenstorms macroglobulinemia is :
(A) Lymphadenopathy is usually present
(B) Blood viscosity increased
(C) IgM immunoglobulin increased
(D) Hypercalcemia
195. Chloroma is due to :
(A) AML
(B) CLL
(C) ALL
(D) Non Hodgkin’s lymphoma
196. In atherosclerosis, increased LDL in monocyte macrophage due to :
(A) LDL receptors on marophage
(B) LDL receptors on endothelium
(C) Lipids in LDL get auto oxidized
(D) All of the above
197. Hb A 2 concentration in thalassemia trait is :
(A) 1
(B) 1-2.5
(C) 2.5-3.5
(D) 3.5
198. Homer wright’s rossette are seen in :
(A) Neuroblastoma
(B) Astrocytoma
(C) Meningioma
(D) Pinealoma
199. Donath Landsteiner antibody is seen in :
(A) PNH
(B) Waldenstrom’s macroglobulinemia
(C) Paroxysmal cold hemoglobinuria
(D) Malaria
200. Which not true regarding coeliac disease :
(A) Total and sub-total villous atrophy
(B) Increased chance of lymphoma
(C) Anti-gliadin antibody persists even after gluten free diet
(D) ↑ disacharidases
201. Large kidney is seen in A/E :
(A) Benign nephrosclerosis
(B) Lymphoma
(C) Amyloidosis
(D) DM
202. Antitrypsin deficiency is associated with :
(A) Restrictrictive lung pathology
(B) Cystric fibrosis
(C) Emphysema
(D) Carcinoma
203. Increased liver attenuation with intracellular infiltration is seen in :
(A) Fatty liver
(B) Amyloidosis
(C) Hemochromatosis
(D) All
204. Characteristic of alcoholic liver is :
(A) Perivenular fibrosis
(B) Maolory hyaline
(C) Spotty necrosis
(D) Zonal necrosis
205. Allo graft is between :
(A) Individuals of same genetic constitution
(B) Individuals of same species with different genetic indentity
(C) Twins
(D) Members of different species
206. Negri bodies are seen in :
(A) Oligodendroglia
(B) Neuron
(C) Microglia
(D) Astrocytes
207. Lymphoepithelial change in stomach is seen in :
(A) Maltoma
(B) Coeliac ds
(C) Ipsidoma
(D) IBS
208. Nesidioblastoma is due to hyperplasia of :
(A) Alpha cell
(B) Beta cell
(C) Acinus
(D) D cells
209. Commonest sarcoma in children is :
(A) Rhabdomyosarcoma
(B) Lipoma
(C) Angiosarcoma
(D) Fibrosarcoma
210. All are true about minimal change GN except :
(A) Selective proteinuria
(B) IgG deposition in mesangium
(C) Common in age group 2-9 years
(D) Responds to steroids
211. Epimembranous deposition is seen in :
(A) Good Pasteur syndrome
(B) Membranous GN
(C) MPGN
(D) MCD
212. All of the following are helpful for diagnosis of medullary Ca thyroid except :
(A) Spindle cell stroma with few follicles
(B) Amyloid deposition
(C) Calcitonin in stroma
(D) Histological mitochondria is essential for diagnosis
213. Life-span of Neutrophil :
(A) 15 days
(B) 6 hours
(C) 6 days
(D) 10 days
214. Microangiopathic hemolytic anemia :
(A) TTP
(B) ITP
(C) Senile pupura
(D) CML
215. In sickle cell anaemia true is :
(A) Autosplenectomy due to thrombosis & infarction
(B) Microcytosis
(C) Microcardia
(D) Splenomegaly
216. Hereditary spherocytosis is due to ….deficiency :
(A) Spectrin
(B) Invertin
(C) Cytokeratin
(D) All of the above
217. Psammoma bodies are seen in following except :
(A) Serous cystadenoma of ovary
(B) Mucinous cystadenoma of ovary
(C) Meningioma
(D) Papillary carcinoma of thyroid
218. In reflux nephropathy, glomerular lesion is :
(A) Focal G.N.
(B) Membranous G. N.
(C) Membrano proliferative G.N.
(D) Minimal change disease
219. True about membranous GN are following except :
(A) Thickening of B.M
(B) Deposition between endothelium and B.M.
(C) Most common cause of nephritic syndrome in adults
(D) Seen in SLE, tumors, drugs
220. In multiple myeloma-amyloid is
(A) AL
(B) AA
(C) ATTR
(D) Aβ₂m
221. Following will cause CNS-vasculitis except :
(A) SLE
(B) Whipples disease
(C) Granulomatous vasculitis
(D) PAN
- Lung is characteristically involved in :
(A) Churg-Strauss syndrome
(B) HSP
(C) PAN
(D) ITP
223. DIC occurs in :
(A) Myelomonocytic leukemia
(B) Promyelocytic leukemia
(C) Monocytic
(D) Aleukemic leukemia
224. ‘Popcorn-cells’ are seen in which variety of hodgkin’s disease :
(A) Nodular sclerosis
(B) Mixed cellularity
(C) Lymphocyte predominance
(D) lymphocyte depletion
225. Glomerulonephritis associated with AIDS is :
(A) Focal segmental GN
(B) PSGM
(C) MPGN
(D) Membranous GN
226. Anti ds-DNA antibodies are commonly seen in :
(A) SLE
(B) Scleroderma
(C) PAN
(D) Dermatomyositis
227. Secondaries are common in a/e :
(A) Skull
(B) Hand & feet bones
(C) Proximal limb bones
(D) Pelvic
228. Epithelial granuloma is caused by :
(A) Neutrophil
(B) Cylotoxic T-cells
(C) Helper T-cells
(D) NK cells
229. Common type of Ca in middle 1/3rd of oesophagus :
(A) Adeno Ca
(B) Squamns Ca
(C) Adeno squamns Ca
(D) Leiomyosarcoma
230. In anoxia of liver, necrosis is seen in :
(A) Centrilobular
(B) Around the periphery
(C) Around the central vein
(D) Around the bile duct
231. Giant hypertrophy of gastric mucosa similar to brain surface is seen in :
(A) Peptic ulceration
(B) Carcinoma stomach
(C) Menetrier’s disease
(D) Leomyosarecoma
232. Platelet are stored in :
(A) 22 ± ℃
(B) −4 ℃
(C) −2 ℃
(D) −20 ℃
233. Macrocytyic anemia may be seen in all of these except :
(A) Liver disease
(B) Copper deficiency
(C) Thiamine deficiency
(D) Vitamin B₁₂ deficiency
234. Bilateral breast ca is
(A) Scirrhous ca
(B) Medullary ca
(C) Lobular ca
(D) Ductal ca
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