Loyola College B.Sc. Physics April 2012 Bioinformatics – I Question Paper PDF Download

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PHYSICS, COMPUTER SCI. & APPL.

THIRD SEMESTER – APRIL 2012

PB 3208/3202 – BIOINFORMATICS – I

 

 

 

Date : 02-05-2012              Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

PART- A

Answer all the questions:                                                                                            (20 marks)

 

I Choose the correct answer :                                                                                    (5×1=5 marks)

  1. Where is ribosome located in plant and animal cell?
  2. a) inside the nucleus b) on the endoplasmic reticulum
  3. c) near the cell membrane d) inside the vacuole

 

  1. The database that classifies protein according to their structure and function is _______________.
  2. a) PIR-PSD b) i Proclass                 c) ALN                                    d) RESID

 

  1. The one that collects and processes sequence data for PIR-international is ________________.
  2. a) MIPS b) PATS                      c) SMD                                   d) DIP

 

  1. Cells were first discovered by _____________.
  2. a) Robert hooke b) George kohler         c) Edward jenner        d) Pasteur

 

  1. Identify the protein structure analysis database.
  2. a) RCSB-PDB b) RasMol                   c) ProtParam               d) Web-Thermodyn

 

II State whether the following statements are True or False:                               (5×1=5 marks)

  1. ProtParam computes various physico-chemical properties of proteins.
  2. UAA is a start codon.
  3. 3ˊ- 5ˊstrand is called a non-coding strand.
  4. RasMol is licensed dually.
  5. Smith-Watermann algorithm is used to align multiple sequences.

 

III Complete the following:                                                                                      (5×1=5 marks)

  1. JSTOR stands for ________________.
  2. PDB is generated by ______________.
  3. Secondary structure of DNA was proposed by _________________.
  4. RasMol is otherwise called as ___________.
  5. Low helical stability region is predicted by _______________.

 

IV Answer the following each in about 50 words:                                                 (5×1=5 marks)

 

  1. What are restriction enzymes?
  2. Define protein synthesis.
  3. Name the 3 institutes that contribute towards International Nucleotide Sequence database

collaboration?

  1. Illustrate the central dogma of molecular biology.
  2. Write the applications of HGP.

                                               

PART – B

 

Answer the following, each answer within 500 words; Draw diagram wherever necessary:                                                                                                                                                         (5 × 8 = 40 marks)

  1. a) Give an account on the cytoplasmic organelles of eukaryotic cell.

OR

  1. b) Briefly explain transcription process.
  2. a) Write notes on i) EMBL ii) DDBJ

OR

  1. b) Give details of the currently used human genome project.
  2. a) Write short notes on i) disease database                  ii) journal database

OR

  1. b) Explain the steps involved in Needleman and Wunsch algorithm.
  2. a) Describe Chou- Fasman method.

OR

  1. b) Give an account on different types of BLAST program.
  2. a) Explain the software used for visualizing the 3D structure of proteins.

OR

  1. b) Elucidate the software used for predicting the physical properties of nucleic acids.

 

PART – C

 

 Answer any TWO of the following, each answer within 1500 words; Draw diagram wherever necessary:                                                                  (2 × 20 = 40 marks)

 

  1. Draw a Smith-Watermann algorithm for the following using the values of match: 1, mismatch:

0, gap: -1

ADCNGRQCLCRPM

AGCGNRCKCRP

  1. Describe the structure and functions of DNA.
  2. Write notes on i) PIR ii) Swissprot
  3. Explain secondary structure prediction on proteins.

 

 

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Loyola College B.Sc. Mathematics Nov 2012 Bioinformatics – I Question Paper PDF Download

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – MATHEMATICS & PHYSICS

THIRD SEMESTER – NOVEMBER 2012

PB 3208 – BIOINFORMATICS – I

 

 

Date : 09/11/2012             Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

 

                Part –A                                                               (20 marks)

 

Answer the following, each answer within 50 words:                                                    (10×2=20 marks)

 

  1. Mention the central dogma of molecular biology.
  2. Give the types of Mrna.
  3. What is DDBJ?
  4. Expand MIPS and mention its function.
  5. What is a domain?
  6. Give any two objectives of learning bioinformatics.
  7. What is BLAST?
  8. Name any two secondary structures of proteins.
  9. Which database can be accessed to retrieve protein sequences?
  10. Name any two protein structure models.

 

Part B                                                            

 

Answer the following each within 500 words. Draw diagrams wherever necessary:

(5×7=35 marks)

  1. a) Explain the structure of chromosome.

 

(OR)

 

  1. b) Explain the secondary structure of Proteins.

 

  1. a) Define PIR database and explain its types.

 

(OR)

 

  1. b) Define Genomic database and explain the subfields in Genomics.

 

  1. a) Mention the uses of FASTA and BLAST in sequence alignment.

 

(OR)

 

  1. b) Write about Local alignment and Multiple Sequence alignment.

 

 

  1. a) How to study the physical properties of proteins using internet?

 

(OR)

 

  1. b) What are repetitive sequences and how are they masked?

 

  1. a) Compare the usage of WEBTHERMODYN and DNAlive in predicting the physical properties of

DNA.

 

(OR)

 

  1. b) Write about any one protein visualization tool.

 

 

 

                                         Part C                                                                  

 

Answer any three of the following each within 1200 words. Draw diagrams wherever necessary:                                                                                                                                (3×15=45 marks)

 

  1. Explain the structure and function of DNA.
  2. Describe the projects carried out by HGP and mention their applications.
  3. What is OMIM? Mention its significance and the procedure.
  4. Explain Needleman- Wunsch and Smith-Waterman Algorithms.
  5. Describe the steps involved in Gene Finding.

 

 

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