LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
B.Sc. DEGREE EXAMINATION – PHYSICS & CHEMISTRY
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FOURTH SEMESTER – APRIL 2007
PB 4204 – BIOINFORMATICS – II (GENOMICS & PROTEOMICS)
Date & Time: 19/04/2007 / 9:00 – 12:00 Dept. No. Max. : 100 Marks
PART A
Answer all the following questions (20 marks)
- Choose the correct answer (5 x 1 = 5 )
- ________ score presents the signal peptide cleavate site .
- a) C b) S c) A d) Y
- PDB is a database of ________.
- secondary structures b) transmemrane helices
- c) 3D structures d) motifs.
- The noncoding regions of genomes are known as ________.
- a) introns b) exons c) promoter d) signal peptides.
- 5‘ capping is a ________modification.
- post transcriptional b) translational
- c) splicing d) sequencing.
- ________ is the software for promoter site prediction.
- promoter 2.0 b) promoter 3.0
- c) promoter 6.0 d) promoter 1.0
- State whether the following statements are True or False (5 x 1 = 5 )
- Gene cloning can be used to produce insulin.
- Codon bias is the unequal usage of codons for aminoacids.
- C score is used to predict the signal peptide cleavate sites.
- Genscan predicts INIT, INTR and TERM exons.
- Promoter regions are present in the upstream region of the genes.
III. Complete the following (5 x 1 = 5)
- Donor site is the beginning of ________.
- ________ is the enzyme for bioluminescence in glow worms.
- ________ are the enzymes used to cut DNA sequences.
- ________ are used as vectors in cloning.
- ________ is the software for visualizing protein structures.
- Answer the following each within 50 words . (5 x 1 = 5)
- What is Splicing ?.
- Explain Drought resistance.
- Discuss the Importance of CpG island.
- What is an atomic coordinate file ?.
- Define : exon.
PART B
Answer any five of the following each in about 350 words. Draw diagrams wherever necessary.
(5 x 8 = 40)
- Discuss the applications of bioinformatics.
- Explain the software for the prediction of post translational modification (glycosylation).
- Explain the signalp software in detail.
- Discuss any two softwares for the analysis of genomes.
- Explain the software for the prediction for transmembrane helix prediction.
- Discuss codon usage databases and their applications.
- Discuss Netgene 2 and its applications.
- Discuss about promoter 2.0 and its output format.
PART C
Answer the following questions in about 1500 words. Draw diagrams wherever necessary
(2 x 20 = 40)
- a) Explain gene cloning with Insulin as an example.
OR
- Discuss the gene prediction software genscan in detail.
- a) Discuss the applications of Bioinformatics..
OR
- Explain DNA sequencing in detail.
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