LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – CHEMISTRY.

VE 06

THIRD SEMESTER – April 2009

PB 3204 – BIOINFORMATICS – I

 

 

 

Date & Time: 16/04/2009 / 1:00 – 4:00         Dept. No.                                                       Max. : 100 Marks

 

 

 

PART A

 

Answer all the questions                                                       (20 marks)

 

1. Choose the best answer (5X1=5)

 

Answer all the questions

1. Data model used in bioinformatics application is
2. a) hierarchial b)relational c)network d)multidimensional
3. NCBI hosts
4. a) BLAST b) FASTA c)DDBJ           d)Lalign
5. Aromatic aminoacids are
6. a) tyrosine and tryptophan
7. b) tyrosine and threonine
8. c) phenylalanine and alanine
9. d) phenylalanine and leucine
10. Double helical model of DNA was published by
11. a) Watson and Crick
12. b) Linus Pauling and Crick
13. c) Rosalind Franklin and Crick
14. d) Corey and Watson
15. Addition of adenine to mRNA is called
16. a) 3’ modification
17. b) 5’ modification
18. c) Poly A tailing
19. d) Polymerase Chain reaction

 

1. State whether the following true or false (5X1=5)

 

6. Chargaff rule says A=T and G=C.
7. Removal of introns and reunioin of exons is called Splicing.
8. RefSeq is a standard database for comparative analyses.
9. Cn3D is compatible with PDB.

10.NebCutter tool identifies restriction sites.

 

 

 

 

III. Complete the following                                                                          (5X1=5)

 

11. Proline and glycine are found in _______ of protein secondary structure.
12. Proof reading function of polymerase is due to________ activity.
13. PubChem Substance is a _________ database.

 

14._________ are produced by gene duplication within a species but has different functions.

15. The latest genome sequenced is from an endangered species _______.

 

1. Answer the following, each not exceeding 50 words. (5X1=5)

 

16. Compute pI/MW
17. Expand HSP
18. What is a Start codon?
19. Define DotPlot
20. What is a Rooted Phylogenetic Tree?

 

PART B

                                                                                    (5X8=40)

Answer any five of the following, each not exceeding 350 words.

Draw diagrams and flowcharts wherever necessary.

 

21. Explain OMIM and its features.
22. What are the features of PDB?
23. Discuss about BLAST and its types.
24. How will you analyze the gene structure in eukaryotes using software tools?
25. List the databases involved in Protein Domain analyses.
26. Explain about proteomic tools.
27. Detail the various molecular visualization tools with emphasis on Homology modeling.
28. Write about ORF finder of NCBI.

 

PART C

Answer the following, each not exceeding 1500 words                  (2X20=40)

Draw diagrams and flowcharts wherever necessary.

 

29a) Explain Smith Waterman Local Algorithm by aligning the following sequences

ACG TAT CGC GTA TA

GAT GCT CTC GGA AA

Or

1. b) Elaborate upon Multiple Sequence alignment and its software tools.

 

30 a) Write about the mechanism of translation of protein in detail.

Or

1. b) How does the process of DNA replication occur inside the cell?

 

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