LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – CHEMISTRY

AD 08

FIFTH SEMESTER – NOV 2006

CH 5401 – BIO CHEMISTRY

(Also equivalent to CHE 401/CH 520)

 

 

Date & Time : 01-11-2006/9.00-12.00   Dept. No.                                                       Max. : 100 Marks

 

 

 

PART – A

Answer all the questions                                                     (10 ×2 = 20 marks)

 

1. What are essential amino acids? Give any two examples.
2. Define point mutation. Explain with respect to sickle cell anaemia.
3. Mention the factors influencing enzyme action.
4. What are waxes? Give example.
5. Expand the terms EFA and PUFA. Give an example for each.
6. Draw the pyranose structure of glucose and the furanose structure of fructose.
7. ‘Glycogen highly branched whereas starch is not.’ Why?
8. Explain the fork model for DNA replication.
9. What are plasma proteins? Give example.
10. Define the terms catabolism and anabolism.

 

 

 

PART – B

Answer any eight questions                                                (8 × 5 = 40 marks)

 

11. Give the structure and functions of the following organelles.
    a) centriole b) lysosome                 c) chloroplast.
12. How are proteins sequenced from the N-terminal using Edmann’s reagent and C- terminal using enzymes?
13. Define enzyme immobilization. Explain the various methods of enzyme immobilization.
14. Give the advantage of solid-phase peptide synthesis. Explain how peptides are synthesized by solid phase method.
15. What are coenzymes? Explain the mechanism of coenzyme action.
16. Explain the biosynthesis of cholesterol.
17. Define the following with suitable examples
    a) Hydrogenation of fats.
    b) auto-oxidation of fats
    c) saturated and unsaturated fatty acids.
18. ‘Starch is edible whereas cellulose is not.’ Explain.
19. Explain glycolysis.
20. Differentiate between DNA and RNA.
21. Explain the electron transport chain.
22. How is blood coagulated?

 

 

 

 

 

 

 

 

 

 

 

PART – C

Answer any four questions                                                (4 × 10 = 40 marks)

 

23. Explain the following
    a) Strecker’s synthesis of amino acids
    b) Phthalimide synthesis of amino acids
    c) Reaction of ninhydrin with amino acids
    d) ornithine cycle
24. What are inhibitors? Explain competitive, non-competitive and allosteric inhibitions.
25. a) How are fatty acids biosynthesized?
    b) How are triglycerides biosynthesized?
26. a) Explain TCA cycle.
    b) Define mutarotation and explain with reference to glucose.
27. How are proteins biosynthesized?
28. Explain the following
    a) DNA replication.
    b) The base pairing in DNA
    c) DNA is the genetic material whereas RNA is not.

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