LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.

ED 13

FIFTH SEMESTER – November 2008

PB 5407/PB 5404 – BIOINFORMATICS

 

 

 

Date : 14-11-08                     Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

                                                                 PART – A                                                        (20 marks)

Answer ALL questions.                                                                        

 

I  Choose the correct answer                                                                                           (5×1= 5 marks)

 

1. Software used for drug designing
2. INSIGHTII b)  GENSCAN  c)  GLIMMER  d) GRAIL
3. Software used for gene expression analysis
4. GENOVIZ b)  GENSCAN  c)  GLIMMER  d) GRAIL
5. Database for structural classicification of proteins
6. SCOP b) CATH  c) SGD  d) PROSITE
7. Tool used for homology modelling
8. a) MODELLER b) PIPMAKER  c) AUTODOCK  d) INSIGHTII
9. Tool used for pathway analysis
10. KEGG b) MODELLER   c)  AUTODOCK d)  INSIGHTII

 

II  State whether the following true or false :                                                              (5×1= 5 marks)

• ________ is termed as non coding region.
• ________ is a tool for the gene prediction in microbial genomes.
• The size of the Homa sapien  genome is _________.
• Clustalw developed by ___________.
• ________ is a database for domains & protein families.

 

II  Complete the following:                                                                                              (5×1=5 marks)

 

• —————- is  a Restriction Site tool.
• ———— is Splice Site Prediction tool
• Rasmol is—————-.
• ————– is multiple sequence alignment tool.
• DDBJ is maintained by——————-.

 

IV  Write notes on the following, each not exceeding 50 words.                              (5×1=5 marks)

 

• Write notes on Restriction site
• Define Swiss-model
• Difference between Local & Global alignment
• Comment on BLAST
• Define INTERNET.

 

PART – B

 

Answer any FIVE of the following, each not exceeding 350 words (8×5= 40 marks)

Draw diagrams / flow charts wherever necessary.

 

•  Explain the Post Translational Modifications of proteins  with a appropriate example.
• Explain the principles, types of
• What are the levels of protein structure & explain them briefly with a appropriate diagram
• Write notes on a) Paralogs b) Orthologs d) Steps  involved in  Phylogenetic Analysis.
• Explain briefly about S-W algorithm & add on differences between N-W & S-W algorithm
• Explain any two important online journal databases briefly.
• Write briefly about Genomic databases
• Give short notes on

1. a) Splicing and its Prediction Tools
2. b) Software for the Prediction of physical properties of proteins          

 

PART – C

 

Answer the following, each not exceeding 1500 words.

Draw diagrams / flow charts wherever necessary                                                (2×20=40 marks)

• (a) What is Homology Modelling? Explain briefly about the Steps involved in it ?

(OR)

• Explain in detail about Secondary Structure of

30. (a) Explain briefly about Genomic Comparisons. Add a steps and  tools  involved in it

(OR)

1. b) Explain about the primary and  secondary databases. 

 

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