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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.
THIRD SEMESTER – November 2008
ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY
Date : 10-11-08 Dept. No. Max. : 100 Marks
Time : 9:00 – 12:00
Section A
Answer ALL the questions: (10 x 2 = 20 marks)
- Diethyl ether is a stronger hypnotic than acetone – Comment
- What is chelation? Give an example.
- What are the different effects caused by morphine in different species?
- Account for the antibacterial activity of aminoacridines.
- Mention the importance of organometallic compounds with examples.
- What are the units of radioactivity?
- Define pharmacodynamics.
- Mention the toxic effect of solvents.
- What are the three different types of interaction of toxic substances?
- Define renal clearance.
Section B
Answer any FOUR of the following : (4 x 10 =40 marks)
- (a) What are preservatives and antioxidants? Give examples. (5)
(b) Explain therapeutic index and safety factor. (5)
- Explain the correlation of antimicrobial activity with chelating property with suitable examples.
- What are pharmacodynamic agents? Discuss their classification.
- Write short notes on teratogens.
- Explain scintillation counter and Geiger Muller counter.
- Compare the biotransport process of drugs.
Section C
Answer any TWO of the following: (2 x 20 = 40 marks)
- (a) Explain (i) Labeling by isotope exchange. (ii) Labeling by irradiation by tritium. (7)
(b)Discuss the effect of (a) isomerism (ii) Halogens (iii)aldehydes and ketones on the
activity of a drug. (8)
(c) Explain any two types of ointment bases with examples. (5)
- (a) Discuss the classification of drugs involved in metabolic diseases and endocrine function. ( 8)
(b) Explain the principles of NMR and X-ray diffraction technique used in the
characterization of drugs. (12)
- Explain the different methods of administering drugs into the body.
- Explain in detail radioimmunoassay.
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