LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034  B.Sc. DEGREE EXAMINATION – CHEMISTRY

AE 04

THIRD SEMESTER – NOV 2006

         PB 3202 – BIOINFORMATICS

 

 

Date & Time : 31-10-2006/9.00-12.00         Dept. No.                                                       Max. : 100 Marks

 

 

 

 

Part A

Answer all the questions                                                                              (20 marks)

 

I      Choose the correct answer                                                                  (5 x1  = 5)

 

1. Pubmed is a ________ database.

a)gene             b) sequence                  c) journal             d) disease.

2. ________ is a protein structure visualization tool.
3. a) rasmol b) genbank       c)  bioedit            d) NCBI
4. PDB is a ________ database.
5. a) sequence b) structure   c) pathway          d) journal.
6. Pattern is a representation of ________.
7. a) gene   b) structure             c) motif             d) genome
8. Alpha helix is a protein________ structure.
9. a) primary b) secondary                 c) tertiary           d) quarternary.

 

 

II State True or False                                                                                    (5 x 1  =5)

 

6. X represents any aminoacid in a pattern.
7. Blastp is used for searching protein sequences in databases.
8. Beta sheet is a tertiary structure.
9. Protein structure can be downloaded from Rasmol.
10. Genscan is used for protein structure analysis..

III  Complete the following                                                                (5 x 1 = 5)

 

11. ________ is the RNA which transfers the aminoacids.
12. The double helical structure of DNA was proposed by ________.
13. Swissprot is a protein________ database.
14. Fasta format begins with a ________ symbol.
15. ________ is the software for multiple sequence alignment..

 

 

 

 

 

 

 

IV Answer  the following, each in 50 words                                   .             (5 x  1 = 5)

 

16. What is Accession number.
17. What is Genetic codon.
18. Explain : Restriction enzymes.
19. What are Purines.
20. Define : GC%.

PART B

 

Answer any Five of the following , each in about 350 words.                 (5 x 8 =40)

 

21. Explain NCBI, DDBJ and EMBL.
22. Discuss the applications of Bioinformatics.
23. Explain Genscan and its applications. .
24. Explain the double helical structure of DNA.
25. Ezplain the secondary structure prediction tool .(sopma or nnpredict).
26. Ezplain any 5 commands in Rasmol.
27. Describe ORF finder in detail.
28. Explain a software for nucleic acid sequence analysis.

PART C

 

Answer any Two of the following, each  in about 1500 words.               (2 x 20 = 40)

Draw diagrams / flowcharts wherever necessary.

 

 

29.a) Explain Genbank and its file format.

Or

29..b) Explain BLAST,  its types and significance.

 

30.a) Explain about  protein synthesis in detail.

Or

30.b) Explain any two protein sequence databases.

 

 

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