LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

AH 08

THIRD SEMESTER – NOV 2006

                        ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY

 

 

Date & Time : 06-11-2006/9.00-12.00   Dept. No.                                                       Max. : 100 Marks

 

 

PART A

 

Answer all the questions                                                         (10×2=20 Marks)

 

1. Give the difference between ‘invivo’ and ‘invitro’ analysis of drugs.
2. Explain the terms : a) Pharmacology b) Pharmacophore c) Pharmacokinetics
3. d) Pharmacodynamics
4. What are the different isotopes of carbon? How is it useful in medicinal field?
5. What is meant by ‘cut off point’? Give an example.
6. What is meant by ‘Buffer’? Mention its significance in designing drugs.
7. What are the four basic types of chemical interactions?
8. Define Lamellae & Liminent.

8.What is meant by first pass biotransformation.

9.Define FAS.

10. What is meant by Intraosseous route of administration?

 

PART B

 

Answer any four of the following:                                                        (4×10=40 Marks)

 

11. Explain briefly with examples
12. a) Preservatives b) Ointment bases  c) Colouring and sweetening agent in drugs.
13. Explain the relationship between the chemcal structure and pharmacological activity

using alkyl and acidic groups in drugs.

13. Discuss the importance of chelation in explaining the biological activity of

compounds.

14. Discuss the factors influencing Toxicity.
15. Explain the different methods of administering drugs.
16. What are the applications of radioisotopes in biological sciences.

 

PART  C

 

Answer any two of the following:                                                         (2×20=40 Marks)

 

17. a) Explain the classification of drugs with examples
18. b) How is radioactivity measured by Geiger – Muller counters
19. Enumerate the physiochemical constants for prediction of bio activities.

19.Classify teratogens and write short notes on

1. Fetal alcohol Syndrome b)Phenytoin c)Thalidomide
2. Explain the process of drug absorption.

 

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

HP 06

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

THIRD SEMESTER – APRIL 2007

ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY

 

 

 

Date & Time: 03/05/2007 / 9:00 – 12:00      Dept. No.                                       Max. : 100 Marks

 

 

PART A

 

Answer all the questions                                                         (2×10=20 Marks)

 

1. Mention any two functions in the action of drugs.
2. What are isotopes? Give the different isotopes of hydrogen.
3. Give the name and structure of any two sweetening agent used in drugs.

4.What is ‘Biosterism’? Explain with an example.

5. What is meant by ‘Chelation’? Mention any two important aspects of chelation in

medicine.

6. What are the four basic types of damage caused by toxic materials?
7. Define Fetal Alcohol Syndrome.
8. What is Genetic Toxicity?
9. What is meant by first pass biotransformation?
10. List the advantages of scintillation counter over GM counter.

 

 

PART B

 

Answer any four of the following:                                                            (10×4=40 Marks)

 

11. Explain the role of chemical structure in pharmacological activity taking any two

functional groups.

12. What is ‘Metabolite antagonism’? Explain with two examples.
13. How is radioactivity measured using Geiger- Muller counter and Scintillation

counter?

14. How are teratogens classified? Which is the most sensitive period for teratogens in

pregnancy.

15. Discuss the physiological barriers in drug distribution.
16. List the different immunoassay techniques. Explain RIA.

 

PART  C

 

Answer any two of the following:                                                              (20×2=20 Marks)

 

17. Explin the different types of pharmaceutical aids used in drugs.
18. (a). Discuss the importance of biological testing of drugs.

(b). Explain briefly the role of solubility, partition coefficient and steric factors in

designing drugs.

19.Write in detail absorption, distribution and excretion of toxic substances.

20.Describe in detail the different routes of elimination of drugs from the body.

 

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