ML 1808 – CLINICAL BIOCHEMISTRY

(Also equivalent to ML 1801)

Date & Time : 28-10-2006/1.00-4.00 Dept. No. Max. : 100 Marks

PART-A

Answer all the questions (10 x 2 = 20)

Distinguish metabolic acidosis and respiratory acidosis.
Draw hazard symbol of very toxic and irritant compounds.
What is Embden-Meyerhof pathway?
Write the function of parafollicular C cells in the thyroid gland.
Name the marker compound present in the colon, pancreatic, breast and ovarian cancers.
What is reverse cholesterol transport process?
Draw the structure of haemoglobin.
What is the antioxidant property of Vitamin E?
Expand the abbreviations: PSA, BTA, and APAF.
Define the term: Ochronosis.

PART-B

Answer any four of the following (4 X 10 = 40)

What are cardiac enzymes? Explain their functions and clinical significance.
Write a short note on pancreatic function test.
Describe in detail the synthesis and biochemical functions of thyroid hormones.
What are non-protein nitrogen substances? Add a note on urea formation.
Describe in detail the renal function test.
Give the normal values and biological importance of electrolytes Na⁺, K^+,Cl^–, Ca²⁺ and Mg²⁺.

PART – C

Answer any two of the following (2 X 20 = 40)

Write an essay on the enzymes of gastrointestinal tract involved in the digestion of

carbohydrates and proteins.

Explain citric acid cycle with structure and regulatory mechanism.
What is lipid profile? Write the principle, procedure, normal value and clinical

significance of any three lipid profile test.

Describe in detail the difference laboratory investigations employed to assess liver function.