Loyola College M.Sc. Medical Lab Technology Nov 2006 Pharmaceutical Chemistry And Toxicology Question Paper PDF Download

                       LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

AH 08

THIRD SEMESTER – NOV 2006

                        ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY

 

 

Date & Time : 06-11-2006/9.00-12.00   Dept. No.                                                       Max. : 100 Marks

 

 

PART A

 

Answer all the questions                                                         (10×2=20 Marks)

 

  1. Give the difference between ‘invivo’ and ‘invitro’ analysis of drugs.
  2. Explain the terms : a) Pharmacology b) Pharmacophore c) Pharmacokinetics
  3. d) Pharmacodynamics
  4. What are the different isotopes of carbon? How is it useful in medicinal field?
  5. What is meant by ‘cut off point’? Give an example.
  6. What is meant by ‘Buffer’? Mention its significance in designing drugs.
  7. What are the four basic types of chemical interactions?
  8. Define Lamellae & Liminent.

8.What is meant by first pass biotransformation.

9.Define FAS.

  1. What is meant by Intraosseous route of administration?

 

PART B

 

Answer any four of the following:                                                        (4×10=40 Marks)

 

  1. Explain briefly with examples
  2. a) Preservatives b) Ointment bases  c) Colouring and sweetening agent in drugs.
  3. Explain the relationship between the chemcal structure and pharmacological activity

using alkyl and acidic groups in drugs.

  1. Discuss the importance of chelation in explaining the biological activity of

compounds.

  1. Discuss the factors influencing Toxicity.
  2. Explain the different methods of administering drugs.
  3. What are the applications of radioisotopes in biological sciences.

 

PART  C

 

Answer any two of the following:                                                         (2×20=40 Marks)

 

  1. a) Explain the classification of drugs with examples
  2. b) How is radioactivity measured by Geiger – Muller counters
  3. Enumerate the physiochemical constants for prediction of bio activities.

19.Classify teratogens and write short notes on

  1. Fetal alcohol Syndrome b)Phenytoin c)Thalidomide
  2. Explain the process of drug absorption.

 

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