LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY
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THIRD SEMESTER – NOV 2006
ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY
Date & Time : 06-11-2006/9.00-12.00 Dept. No. Max. : 100 Marks
PART A
Answer all the questions (10×2=20 Marks)
- Give the difference between ‘invivo’ and ‘invitro’ analysis of drugs.
- Explain the terms : a) Pharmacology b) Pharmacophore c) Pharmacokinetics
- d) Pharmacodynamics
- What are the different isotopes of carbon? How is it useful in medicinal field?
- What is meant by ‘cut off point’? Give an example.
- What is meant by ‘Buffer’? Mention its significance in designing drugs.
- What are the four basic types of chemical interactions?
- Define Lamellae & Liminent.
8.What is meant by first pass biotransformation.
9.Define FAS.
- What is meant by Intraosseous route of administration?
PART B
Answer any four of the following: (4×10=40 Marks)
- Explain briefly with examples
- a) Preservatives b) Ointment bases c) Colouring and sweetening agent in drugs.
- Explain the relationship between the chemcal structure and pharmacological activity
using alkyl and acidic groups in drugs.
- Discuss the importance of chelation in explaining the biological activity of
compounds.
- Discuss the factors influencing Toxicity.
- Explain the different methods of administering drugs.
- What are the applications of radioisotopes in biological sciences.
PART C
Answer any two of the following: (2×20=40 Marks)
- a) Explain the classification of drugs with examples
- b) How is radioactivity measured by Geiger – Muller counters
- Enumerate the physiochemical constants for prediction of bio activities.
19.Classify teratogens and write short notes on
- Fetal alcohol Syndrome b)Phenytoin c)Thalidomide
- Explain the process of drug absorption.