LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
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M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.
THIRD SEMESTER – APRIL 2007
ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY
Date & Time: 03/05/2007 / 9:00 – 12:00 Dept. No. Max. : 100 Marks
PART A
Answer all the questions (2×10=20 Marks)
- Mention any two functions in the action of drugs.
- What are isotopes? Give the different isotopes of hydrogen.
- Give the name and structure of any two sweetening agent used in drugs.
4.What is ‘Biosterism’? Explain with an example.
- What is meant by ‘Chelation’? Mention any two important aspects of chelation in
medicine.
- What are the four basic types of damage caused by toxic materials?
- Define Fetal Alcohol Syndrome.
- What is Genetic Toxicity?
- What is meant by first pass biotransformation?
- List the advantages of scintillation counter over GM counter.
PART B
Answer any four of the following: (10×4=40 Marks)
- Explain the role of chemical structure in pharmacological activity taking any two
functional groups.
- What is ‘Metabolite antagonism’? Explain with two examples.
- How is radioactivity measured using Geiger- Muller counter and Scintillation
counter?
- How are teratogens classified? Which is the most sensitive period for teratogens in
pregnancy.
- Discuss the physiological barriers in drug distribution.
- List the different immunoassay techniques. Explain RIA.
PART C
Answer any two of the following: (20×2=20 Marks)
- Explin the different types of pharmaceutical aids used in drugs.
- (a). Discuss the importance of biological testing of drugs.
(b). Explain briefly the role of solubility, partition coefficient and steric factors in
designing drugs.
19.Write in detail absorption, distribution and excretion of toxic substances.
20.Describe in detail the different routes of elimination of drugs from the body.
