LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

AH 03

FIRST SEMESTER – NOV 2006

ML 1809 – MOLECULAR BIOLOGY

 

 

Date & Time : 31-10-2006/1.00-4.00       Dept. No.                                                       Max. : 100 Marks

 

 

SECTION-A

Answer all the questions                                                       2X10=20marks

1. Mention the role of topoisomerases?
2. Draw the secondary structure of t-RNA
3. What is Chargaff’s rule?
4. Write notes on a) heterochromatin b) euchromatin
5. List the different kinds of lysosomes and their functions
6. What is RNA polymerase holoenzyme?
7. What is photoreactivation repair mechanism?
8.  Expand the abbreviations

1. a) APC b) CDKS

1. What is the role of tyrosine kinases in cancer?
2.  What is Turner’s syndrome?

SECTION-B

Answer any four of the following                                        4X10=40marks

 

1. Explain the special constraints relevant to genetic testing
2. Explain the molecular structure of double stranded DNA.
3. Describe the mechanism of transcription in eukaryotes.
4. What are leading and lagging strands? List out the enzymes of DNA replication and their functions.
5. Write a short note on viral oncogene.
6. Give an account of on excision and recombination repair mechanisms.

SECTION-C

Answer any two of the following                                         2X20=40marks.

 

1. Draw the eukaryotic cell and write notes on a) endoplasmic reticulum.

1. b) golgi complex c) mitochondria.

1. Explain in detail the process of protein synthesis in prokaryotes.
2. Describe in detail the regulation of eukaryotic cell cycle.
3. Explain in detail the active transport of materials across plasma membrane.

 

 

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