LOYOLA COLLEGE (AUTONOMOUS), CHENNAI– 600 034

M.Sc. DEGREE EXAMINATION -medical laboratory technology

FIRST SEMESTER – NOVEMBER 2003

ML 1801  clinical BIOCHEMISTRY

06.11.2003                                                                                        Max: 100 Marks

1.00 – 4.00

 

 

SECTION – A         

Answer the following in ONE or TWO sentence                     (10 ´ 2 = 20 Marks)

 

1. Differentiate glycogenolysis, from gluconeogenesis.
2. Urea and Uric acid are the end products of __________.
3. What is tetany and Gout?
4. What is dysyuris and anuria?
5. What are the isoenzymes of C.P.K name them and where is it found?
6. What is the difference between a colorimeter and spectrophoto meter?
7. Name the hormones which regulate blood sugar.
8. What is the level of urea and creatinine in renal, prerenal and post renal conditions?
9. Name and water soluble and FGT soluble vitamins with their function.
10. Expand ACTH, PTH, S.G.O.T & S.G.P.T.

 

SECTION – B

Answer any four of the following                                       (4 ´ 10 = 40 Marks)

 

11. What is the importance of Alkaline phosphatase? What are the isoemzymes

of alkaline phosphatase? Give a brief account of their physiological role.

12. Give in tabular form the levels of calcium, phosphorous alkaline phosphatase

and urinary calcium in any ten forms of disease.

13. List the liver function test in case of obstructive, hepatocellular and transfusion reactions.
14. What is toxiocology? Give any five substances with their dosage and effects in tabular form.
15. What are electrolytes? State their importance.
16. What is glycosylated haemoglobin? What is its importance in diabetes?

 

 

SECTION – C

Answer any TWO of the following                                         (2 ´ 20 = 40 Marks)

 

17. What are the cardiac enzymes? Name them in order and describe.
18. Describe a colorimeter diagramatically, name the parts and give the corresponding filters used and how does it differ from spectrophotometer diagramatically.
19. What is amylase and acid phosphatse? Give in detail their mode of action and implications.
20. What is lipid profile? Give the lipid classification by fredrickson and explain the conditions.

 

 

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                        LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

AH 02

FIRST SEMESTER – NOV 2006

ML 1808 – CLINICAL BIOCHEMISTRY

(Also equivalent to ML 1801)

 

 

Date & Time : 28-10-2006/1.00-4.00      Dept. No.                                                       Max. : 100 Marks

 

 

PART-A

Answer all the questions                                                                   (10 x 2 = 20)

1. Distinguish metabolic acidosis and respiratory acidosis.
2. Draw hazard symbol of very toxic and irritant compounds.
3. What is Embden-Meyerhof pathway?
4. Write the function of parafollicular C cells in the thyroid gland.
5. Name the marker compound present in the colon, pancreatic, breast and ovarian cancers.
6. What is reverse cholesterol transport process?
7. Draw the structure of haemoglobin.
8. What is the antioxidant property of Vitamin E?
9. Expand the abbreviations: PSA, BTA, and APAF.
10. Define the term: Ochronosis.

PART-B

Answer any four of the following                                                    (4 X 10 = 40)

11. What are cardiac enzymes? Explain their functions and clinical significance.
12. Write a short note on pancreatic function test.
13. Describe in detail the synthesis and biochemical functions of thyroid hormones.
14. What are non-protein nitrogen substances? Add a note on urea formation.
15. Describe in detail the renal function test.
16. Give the normal values and biological importance of electrolytes Na⁺, K^+, Cl^–, Ca²⁺ and Mg²⁺.

PART – C

Answer any two of the following                                                     (2 X 20 = 40)

17. Write an essay on the enzymes of gastrointestinal tract involved in the digestion of

carbohydrates and proteins.

18. Explain citric acid cycle with structure and regulatory mechanism.
19. What is lipid profile? Write the principle, procedure, normal value and clinical

significance of any three lipid profile test.

20. Describe in detail the difference laboratory investigations employed to assess liver function.

 

 

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 12

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1808 – CLINICAL BIOCHEMISTRY

 

 

 

Date : 06-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

PART-A

ANSWER ALL THE QUESTIONS:                                             (10 x 2=20 Marks)

1. Draw the symbol of bio and radiation hazards
2. What is Beer’s and Lambert’s law?
3. What are non-protein nitrogenous substances?
4. What is prostate specific antigen?
5. Name the anti-sterility and anti-pernicious vitamins.
6. What is sodium potassium ATPase?
7. Define the term haemostasis?
8. What is fructosuria?
9. Write the normal values of SGOT, SGPT,ALP and LDH.
10. What is Achlorhydria?

PART-B

ANSWER ANY FOUR OF THE FOLLOWING:                      (4 x 10 =40 Marks)

11. Describe in detail the TCA cycle.
12. What is buffer?Explain blood buffer system.
13. Describe the sources, biological functions and deficiency manifestation of Vitamin A.
14. Write about types, characteristics and functions of lipoproteins.
15. Write short notes on cardiac marker enzymes.
16. Enumerate various functions of the liver and add a note on galactose tolerance test

 

PART-C

ANSWER ANY TWO OF THE FOLLOWING:                          (2 x 20=40 Marks)

17. Discuss the cascade of blood clotting process.
18. Classify vitamins and briefly discuss their function and deficiency disorders of fat soluble vitamins.
19. Describe in detail the liver function test.
20. Describe in detail the renal and respiratory mechanisms of acid base balance

 

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      LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

BV 02

FIRST SEMESTER – April 2009

ML 1808 – CLINICAL BIOCHEMISTRY

 

 

 

Date & Time: 25/04/2009 / 1:00 – 4:00  Dept. No.                                                 Max. : 100 Marks

 

 

PART-A

ANSWER ALL THE QUESTIONS:                                                 (10 x 2=20 Marks)

 

1. What is thyroglobulin?
2. What are pro vitamins of vitamin D?
3. Draw a neat labeled diagram of haemoglobin?
4. Write the principle of Van den Bergh reaction.
5. Explain glycosylated haemoglobin?
6. What is galactosemia?
7. Write any five blood coagulation factors.
8. Define the term Achyliagastrica.
9. Differentiate the metabolic acidosis from alkalosis.
10. What is phenylketonuria?

PART-B

ANSWER ANY FOUR OF THE FOLLOWING:                          (4 x 10 =40 Marks)

 

11. Classify kidney function test. Describe in detail the urea clearance test.
12. Describe in detail function, formation and abnormalities of thyroid hormone.
13. Explain different types of chemical hazards with suitable diagram.
14. Give an account of types, structure and function of hemoglobin.
15. Write short notes on electrolytes.
16. Describe the tumor markers with suitable example.

 

PART-C

ANSWER ANY TWO OF THE FOLLOWING:                          (2 x 20=40 Marks)

 

17. Describe in detail the digestion and absorption of carbohydrate and protein.
18. Discuss the different laboratory investigations to evaluate gastric function.
19. Write an essay on different types of laboratory hazards with suitable example.
20. What is acute toxicity? Explain absorption, distribution and excretion of toxic substance.

 

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB TECH.

FIRST SEMESTER – NOVEMBER 2010

    ML 1808  – CLINICAL BIOCHEMISTRY

 

 

 

Date : 30-10-10                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION-A

ANSWER ALL THE QUESTIONS:                                                                         (10 X 2=20 Marks)

 

1. Name the different zones of laboratory?
2. List down the enzymes involved in TCA cycle.
3. What is Beer’s and Lambert’s law?
4. What is PSB test?
5. What is thyroxine-binding globulin?
6. Define Achyliagastrica.
7. Write the importance of enzyme UDP-glucuranyl transferase.
8. List down the intra and extra cellular electrolytes.
9. What is chylomicron?
10. Differentiate respiratory acidosis from alkalosis.

  

 

SECTION-B

 

ANSWER ANY FOUR QUESTIONS                                                                      (4 X 10=40 Marks)

 

11. 11. Write notes on laboratory safety management.
12. Discuss the reaction, regulation and energy production of glycolysis.
13. Enumerate the various functions and composition of electrolytes.
14. Write notes on tumour markers.
15. Explain the renal mechanism of acid base balance with suitable example.
16. Describe the pancreatic function test.

 

 

SECTION-C

 

ANSWER ANY TWO QUESTIONS                                                                         (2 X 20=40 Marks)

 

 

17. 17. Write an essay on the different laboratory hazards with suitable example.
18. Write notes on: (a) Cardiac marker and (b) TCA cycle.
19. Discuss the mechanism of blood coagulation system.
20. Describe in detail the liver function tests.

 

 

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

FIRST SEMESTER – APRIL 2012

ML 1808 – CLINICAL BIOCHEMISTRY

 

 

Date : 25-04-2012             Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

 

Section – A

 

Answer ALL questions.                                                                            10 x 2 = 20 Marks

 

1. Comment on Cretinism and myxoedema.
2. What is gluconeogenesis?
3. Write the importance of enzyme thyroperoxidase.
4. What are lipoproteins?
5. Name the abnormal hemoglobins.
6. What is urea clearance test?
7. Comment on Gaucher’s disease?
8. Write down the principle of Van den Bergh reaction.
9. What is Von Willebrand syndrome?
10. Name any four hormones which act as a tumor markers.

 

Section – B

 

Answer any FOUR of the following                                                   4 x 10 = 40 Marks

 

11. Classify and explain the different types of laboratory chemicals.
12. Write short notes on cardiac markers.
13. Enumerate the importance of endocrine system and its disorders.
14. Give an account of types, structure and function of hemoglobin.
15. What is Achylia gastric? Explain any three gastric function tests.
16. Describe the clinical importance of tumor markers with suitable example.

 

Section – C

 

Answer any TWO of the following                                                    2 x 20 = 40 Marks

 

17. Describe the mechanism of blood coagulation.
18. Discuss the different laboratory investigations to evaluate liver function.
19. Explain the metabolic pathway of glycolysis and TCA cycle.
20. Elaborate the newborn disorders of carbohydrate and amino acid metabolism.

 

 

 

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

FIRST SEMESTER – NOVEMBER 2012

ML 1808 – CLINICAL BIOCHEMISTRY

 

 

Date : 03/11/2012            Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

 

Section A

Answer ALL the questions:                                                                                          (10×2 = 20 Marks)

 

1. Comment on essential almino acids
2. Define provitamins. Give one example.
3. What is glaucoma?
4. Draw the structure of haemoglobin.
5. Mention the principle involved in Van den Bergh reaction.
6. What is galactosemia?
7. What do you mean by phenylketoneuria?
8. Distinguish acidosis from alkalosis.
9. Define Achyliagastrica.
10. Differentiate uremia from haematuria.

Section B

Answer any FOUR of the following:                                                                           (4×10 = 40 Marks)

 

11. Write notes on blood coagulation factors.
12. Explain kidney function tests.
13. Elaborate abnormalities of thyroid hormone.
14. Categorize and explain chemical hazards.
15. Write notes on the importance of electrolytes.
16. Explain the applications of markers in the diagnosis of tumor.

 

Section C

Answer any TWO of the following:                                                                             (2×20 = 40 Marks)

 

17. Describe digestion and absorption of carbohydrates and fats.
18. Define acute toxicity and explain absorption, accumulation and excretion of toxic substances.
19. Write an essay on categories of laboratory hazards and precautions.
20. Write notes on (i) digestion of protein and   (ii) structure and function of Haemoglobin.

 

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