LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY
FIRST SEMESTER – NOVEMBER 2012
ML 1813 – MOLECULAR BIOLOGY AND CLINICAL BIOCHEMISTRY
Date : 07/11/2012 Dept. No. Max. : 100 Marks
Time : 1:00 – 4:00
PART-AS
Answer ALL the questions: (10 X 2=20 Marks)
- What is galactosemia?
- Define the term achyliagastrica.
- Write down the principle of van den Bergh reaction.
- What is standard and maximum urea clearance?
- Comment on phenylketonuria.
- Write the importance of enzyme Tag polymerase.
- What are codon and anticodon?
- What is Okazaki fragment?
- Comment on missense and non – sense mutation.
- What is Cushing’s syndrome?
PART-B
Answer any FOUR of the following: (4 X 10 =40 Marks)
- Explain the structure and functions of DNA with suitable diagram.
- Discuss different laboratory investigations to evaluate gastric function.
- Explain the formation and function of Bilirubin and add a note on jaundice.
- Describe the mechanism of post transcription modification process.
- Write notes on DNA finger printing and chromosomal walking.
- Describe the clinical importance of tumor markers with suitable example.
PART-C
Answer any TWO of the following: (2 X 20=40 Marks)
- Describe the mechanism of DNA replication with suitable diagram.
- Write about the genetic disorders of metabolism in detail.
- Discuss different laboratory investigations to evaluate renal function.
- Explain the formation, function and clinical importance of thyroid hormones.
