LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.

FOURTH SEMESTER – APRIL 2012

PB 4208 – BIOINFORMATICS – II (GENOMICS & PROTEOMICS)

 

 

Date : 19-04-2012              Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

 

PART –A (20 Marks)

Answer all the questions

1. Choose the best answer:               (5×1= 5 marks)

 

1. Which of the following nucleotide database belongs to Europe?

1. GenBank b. EMBL      c. DDBJ      d.       UniProt

1. What is the total number of genetic codes in a codon usage table?

1. 20 b. 24    c. 60                d. 64

1. Among the following post translational modifications, which is the most important?

1. Acetylation b. Methylation        c. Phosphorylation      d. Glycosylation

1. The following are protein family databases EXCEPT

1. pfam b. PROSITE c. PRINTS        d. BiNGO

1. The size of the spots in a microarray chip is

1. 800microns b. 600 microns c. 400 microns d. 200 microns

 

1. State whether the following are True or False (5×1= 5 marks)

 

1. Psuedogenes are fully functional genes.
2. Promoters are found only on the upstream of a gene.
3. The set of proteins secreted by an organism is a proteome.
4. PDB is a structure based database.

10. The human genome project was completed in 1991.

 

     

III. Complete the following                                                                (5×1= 5 marks)

 

 

1. The size of human genome is__________________.
2. The 5’ splice site is also called _________________.
3. The web based tool used for the prediction of N-glycosylated sites is ________.
4. The biological pathway database is ____________________.
5. Gene ontology refers to ____________ and ______________ function of a gene.

 

1. Answer the following each in about 50 words.      (5×1= 5 marks)

 

1. Restate the definition of a genome.
2. List any one use of DNA sequencing.
3. Give an example of a protein family database.
4. What is a secondary database?
5. Define a clade.

                                                        

 

 

 

 

PART-B                        

Answer the following, each in about 500 words; Draw diagrams wherever necessary.                                                                                              (5×8=40 marks)

 

1. a. Explain about any two nucleotide databases.

(OR)

1. Write about the different stages in DNA coiling.

 

1.   a. What is a genetic code? Explain the significance of Codon Usage Bias.

(OR)

1.   Define:
2. Promoter ii. Enhancer iii. TSS   iv.  Core promoter.

 

1. a. Discuss about any two protein family databases.

(OR)

1. Provide your understanding on glycosylation and phosphorylation of

proteins.

 

1. a. Describe SCOP as a domain structure database.

(OR)

1. How will you study protein- protein interactions?

 

1. a. List the goals and advantages of Human genome project.

(OR)

1.   Comment on Gene Ontology resources.

 

 

PART-C                        

Answer any TWO of the following, each within 1500 words; Draw diagrams wherever necessary                                                                  (2×20= 40 marks)

                                                           

• Elaborate on any two ab initio gene prediction programs.
• Explain the post translational modifications of proteins and add a note on signal

peptides.

• Outline the different levels of protein structure and describe a protein structure

database.

• Examine the different steps involved in Phylogenetic tree building with

illustrations.

 

 

Go To Main Page

 

 

Latest Govt Job & Exam Updates:

View Full List ...