LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.
FIFTH SEMESTER – APRIL 2012
PB 5407 – BIOINFORMATICS
Date : 27-04-2012 Dept. No. Max. : 100 Marks
Time : 1:00 – 4:00
PART-A
Answer the following each within 50 words: (10×2=20)
- What is SWISSPROT?
- What is a quaternary structure of a protein?
- What are the applications of BLAST?
- Define Dot-matrix.
- Explain ORF.
- Differentiate between exons and introns.
- What are motifs?
- List four protein interaction databases.
- What is a 3D structure of a protein?
- What is homology modeling?
PART-B
Answer the following each answer within 500 words; Draw diagrams wherever
Necessary:
(5×7=35)
11.(a) What is a biological database? Explain nucleic acid databases in detail.
OR
(b) Explain the different structural levels of a protein.
12.(a) Differentiate between pair wise alignment and global alignment.
OR
(b) List out the application of alignments.
13.(a) What is a restriction enzyme? Give an algorithm to predict the restriction sites in a protein
sequence.
OR
(b) Give an account on genomic database.
14.(a) Explain any three post translational modifications of a protein.
OR
(b) Briefly explain about Pfam.
15.(a) Give a detailed description on molecular modeling and the techniques used for analysis.
OR
(b) Write notes on PubMed and MedLine.
PART-C
Answer any THREE of the following, each answer within 1200 words; Draw diagrams wherever necessary: (3×15=45)
- Explain protein sequence databases in detail.
- Draw a dynamic programming algorithm for ABCNJRCLCRPM
AJCJNCKCLRBP
- Explain the soft ware used for prediction of physical properties of nucleic acid sequence.
- What are signal peptides? Write a note on motif based databases.
- Give an account on RASMOL.
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