Pharmaceutical Science (PY) Competitive Examination-2013
(GPAT, CET, NIPER etc.)
1. Psig equal to …………. .
(A) psia- 14.7
(B) psia- 15.7
(C) psia- 16.7
(D) pasia- 17.7
2. Enteric tablet coating material is …………. .
(A) Sodium carboxy methyl cellulose
(B) Hydroxypropyl methylcellulose
(C) Povidone
(D) Polyvinyl phthalate acetate
3. Solubility of gelatin capsule is decreased by …………. .
(A) Fumaric acid
(B) Formaline
(C) Titanium oxide
(D) All of the above
4. Which of the following is water is insoluble polymer ?
(A) Hydroxypropyl methylcellulose
(B) Ethyl cellulose
(C) Pollyvinyl pyrrolidone
(D) Hydroxypropyl cellulose
5. In Roche friabilator, plastic chamber revolves at …………. .
(A) 25-rpm
(B) 50-rpm
(C) 15-rpm
(D) 30-rpm
6. Diffusivity of a solute is affected by …………. .
(A) Temperature
(B) Pressure
(C) Chemical nature
(D) All of the above
7. Equation of half life of a substance in zero order reaction is:
(A) 0.693/k
(B) a/2k
(C) 1/ak
(D) 3/2a2k
8. Which of the following is neutral preservative?
(A) Chlorocresol
(B) Chlorobutanol
(C) Phenylmercuric acetate
(D) Thiomersol
9. NCL is located at:
(A) Pune
(B) Kasauli
(C) Chennai
(D) Nagpur
10. Inadequate spreading of the coating solution before drying is called as:
(A) Hazing
(B) Blistering
(C) Cracking
(D) Orange peel effect
11. The mesh size of USP disintegration apparatus is:
(A) 2 mesh
(B) 5 mesh
(C) 10 mesh
(D) 20 mesh
12. According to the Phase rule, where degree of freedom is 3, the system is:
(A) Bivariant
(B) Invarient
(C) Univariant
(D) Trivariant
13. The ratio of dry gelatin / dry glycerin in soft gelatin capsule is:
(A) 0.4/1
(B) 0.6/1
(C) 0.8/1
(D) 1/0.8
14. The term used to describe the settling of an aggregated system & refers to the descending of the boundary between the sediment & the clear supernatant above it is :
(A) Ostwald ripening
(B) Subsidence
(C) Sedimentation
(D) None
15. …………. is dimensionless quantity.
(A) Porosity
(B) Tortuosity
(C) Both
(D) None
16. At the critical temperature, the surface tension of the liquid:
(A) increases up to some extent
(B) does not change
(C) becomes zero
(D) becomes negative
17. When one part of the solute is soluble in nine parts of a solvent, then the solute is:
(A) very soluble
(B) soluble
(C) sparingly soluble
(D) freely soluble
18. Number of significant figures in 28.0 is:
(A) 4
(B) 2
(C) 1
(D) 3
19. Bloom strength of gelatin capsule is directly proportional to :
(A) molecular weight
(B) molecular chain length
(C) solubility of gelatin
(D) forces involved in gelatin molecule
20. HLB values of detergents are in the range of :
(A) 13-16
(B) 8-16
(C) 7-9
(D) 3-8
21. Oral pharmaceutical aerosols involve the use of all propellents except :
(A) trichloromonoflurmethane
(B) dichlorodifluromethane
(C) dichlorotetrafluroethane
(D) isobutane
22. Angle of repose for free flowing powder is:
(A) less than 20°
(B) less than 40°
(C) above 50°
(D) above 80°
23. Chemical nature of asbestos is:
(A) silica
(B) cellulose
(C) alumino silicate
(D) silico tungstate
24. The size reduction of a substance to an extremely fine state by rubbing on a slab with the help of an insoluble liquid is called:
(A) pulverization
(B) levigation
(C) trituration
(D) elutriation
25. Psychrometric chart is related to :
(A) osmotic pressure
(B) humidity
(C) solubility
(D) evaporation
26. The unit of viscosity is :
(A) g/cm.sec
(B) g sec/cm
(C) g.cm.sec
(D) g. cm/sec
27. Magnesia magma is an example of
(A) plastic flow
(B) pseudo plastic flow
(C) dilatants flow
(D) Newtonian flow
28. O°C is equal to …………
(A) 273.61°K
(B) 273.16°K
(C) 273.00°K
(D) 273.68°K
29. Cedar wood oil is used in ………. magnification.
(A) 4x
(B) 10x
(C) 40x
(D) 100x
30. Ashwagandha is also known as:
(A) withania root
(B) shatmuli
(C) virgianian bark
(D) None of these
31. One of the following dominantly contains mucilage:
(A) Isapghol
(B) Cascara
(C) Liquorice
(D) Ajwan
32. When vitamin D is dissolved in chloroform and antimony trichloride solution is added to it, ………. colour appears.
(A) transient blue
(B) pinkish red
(C) yellowish green
(D) greenish yellow
33. In case Eugenia caryophyllus :
(A) calcium oxalate prisms are absent
(B) trichomes are absent
(C) starch is absent
(D) all of the above
34. Canada balsam is used for :
(A) Staining the section
(B) Staining the calcium oxalate crystal
(C) Fixing the section
(D) Staning starch grain
35. Sodium cromoglycate has been developed from ……… molecule found in Ammi visnaga.
(A) Khellin
(B) Tubocurarin
(C) Morphine
(D) Physostigmine
36. Johns wort is widely used in United States mainly as :
(A) Antioxidant
(B) Antitussive
(C) Antidepressent
(D) None of these
37. Biochemical target in pharmaceutical lead discovery may be :
(A) Enzyme
(B) Receptor
(C) Ion channels
(D) All of these
38. HTS mean :
(A) High through put screening
(B) Herbal therapeutic survey
(C) Both (A) & (B)
(D) None
39. Carbohydrate consisting methoxylated polygalacturonic acid is:
(A) Chitin
(B) Cutin
(C) Suberin
(D) Pectin
40. Cystoliths are present in:
(A) Vinca leaves
(B) Datura leaves
(C) Digitalis leaves
(D) Vasaka leaves
41. Covering trichomes present in Datura are:
(A) Uniseriate unicellular
(B) Uniseriate multicellular
(C) Biseriate unicellular
(D) Uniseriate multicellular
42. Spanish Foxglove is:
(A) D. lanata
(B) D. lutea
(C) D. thapsi
(D) D. purpurea
43. In Coriander sativum, primary ridges are :
(A) 8 in number, prominent & straight
(B) 10 in number, prominent & straight
(C) 8 in number, wavy & inconspicuous
(D) 10 in number, wavy & inconspicuous
44. Which is not the characteristic of Gentian root:
(A) Stone cells are absent
(B) Starch grains are absent
(C) Phloem fibres are absent
(D) Calcium oxalate crystals are absent
45. Calcium oxalate crystal in Rauwolfia root is:
(A) Prismatic
(B) Cluster
(C) Acicular
(D) Rossete
46. Aglycon present in ginsenoside is:
(A) dammarol
(B) oleanolic acid
(C) panaxadiol
(D) polygallic acid
47. Virus free plant can be obtained from :
(A) root culture
(B) meristem culture
(C) anther culture
(D) All of these
48. Morphine alkaloids are biosynthesized from ………. amino acid.
(A) phenyl alanine
(B) tyrosine
(C) lycine
(D) alanine
49. Nux vomica contains strychnine not less than :
(A) 1.2%
(B) 2.3%
(C) 2.1%
(D) 3.2%
50. Dragendorff’s reagent is:
(A) potassium mercuric iodide
(B) potassium bismuth iodide
(C) potassium iodide
(D) picric acid
51. Kurchi bark belongs to family :
(A) Rubiaceae
(B) Apocynaceae
(C) Loganiaceae
(D) Leguminoceae
52. The major volatile oil present in Eucalyptus leaves is:
(A) Cineol
(B) Citral
(C) Menthol
(D) Ascaridol
53. Immobilization of enzyme on self-assembling nanocrystalline ceramic core is called as:
(A) aquasome
(B) neosome
(C) transfersome
(D) mesosome
54. In kinetics of cell growth in fermentation process, the phase in which cell number does not vary is called :
(A) latent period
(B) static period
(C) death period
(D) decelerated period
55. All enzymes are ………. in nature.
(A) lipid
(B) protein
(C) carbohydrates
(D) lipopolysaccharides
56. Microorganism used for obtained dextran by fermentation is:
(A) Leuconostoc mesenteroids
(B) Aspergillus oryzae
(C) Trichodermal reesii
(D) Aspergillus niger
57. In the tissue culture, all are used as microelements except:
(A) Mn
(B) Zn
(C) Cu
(D) Mg
58. Immobilization technique involves:
(A) entrapment
(B) complexation
(C) adsorption
(D) All of these
59. The protein part of enzyme is referred as:
(A) haloenzyme
(B) apoenzyme
(C) prosthetic group
(D) activator
60. A gelling agent in case of tissue culture is:
(A) sucrose
(B) cellulose
(C) agar
(D) gum xanthum
61. Which is the functional group transferred by coenzyme pyridoxal phosphate?
(A) aldehyde
(B) H-atom
(C) amino
(D) acyl
62. Extrachromosomal DNA which irreversibly integrate in the host DNA is called:
(A) plasmid
(B) mesosome
(C) episome
(D) None of these
63. Total number of Purine nucleotides is equal to total number of Pyrimidine nucleotides. This is according to:
(A) Watson & Crick model
(B) Bohr’s effect
(C) Chargaff’s rule
(D) None of the above
64. Exonucleases function:
(A) to remove nucleic-acid only from the end of chain
(B) to break bond within the DN chain
(C) to remove sugar part of DNA
(D) all of the above
65. In the cell culture, which gas is used in Cryopreservation of animals cells
(A) O2
(B) N2
(C) SO2
(D) CO2
66. Some enzyme requires metal ion for their activity. The metal ion is called as:
(A) Co-factor
(B) Co-enzyme
(C) Activator
(D) All of these
67. The movement of gene from one chromosome to another or from one site to different one on the same chromosome is called as:
(A) translation
(B) transposition
(C) transformation
(D) translocation
68. Enzyme used for conversion of m-RNA into c-DNA is
(A) DNA polymerase
(B) DNA ligase
(C) Reverse transcriptase
(D) RNA polymerase
69. The agglomeration of several fold chains of amino-acids is known as…….. structure.
(A) Primary
(B) Secondary
(C) Tertiary
(D) Quartenary
70. Gene manipulation to modify germ cells of animals permanently is called:
(A) transgenesis
(B) transphoresis
(C) gene expression
(D) None of these
71. Resolving power of electron microscope is near about:
(A) 1 nm
(B) 0.1 nm
(C) 0.01 nm
(D) 0.001 nm
72. In differential staining techniques, counter stain used is:
(A) neutral red
(B) crystal violet
(C) methyl violet
(D) gentian violet
73. The substances which are incapable to induce antibody formation themselves but can react with antibodies are known as:
(A) Antigen
(B) Haptenes
(C) Complete Antigen
(D) None
74. The bacteria which cannot grow in present of oxygen is termed as:
(A) facultative anaerobes
(B) obligate anaerobes
(C) aerotolerant anaerobes
(D) microaerophiles
75. Diagnostic test for Scarlet fever is:
(A) Frei test
(B) Paulbunnen test
(C) Schulz-Charton test
(D) Elek test
76. The most abundant amino-acid present in the body is:
(A) Alanine
(B) Glutamine
(C) Aspartine
(D) Tyrosine
77. Antibody, which crosses the placental membrane, is:
(A) IgA
(B) IgM
(C) IgG
(D) IgD
78. All of the following are fat soluble vitamins except:
(A) Vit-A
(B) Vit-K
(C) Vit-C
(D) Vit-E
79. Glycolysis occurs in:
(A) Mitochondria
(B) Cytoplasm
(C) Golgi apparatus
(D) Endoplasmic reticulum
80. Krabbe’s disease is due to the defeciancy of:
(A) β-Galactosidase
(B) β-Glucosidase
(C) Ceramidase
(D) Sphingomylinase
81. In normal healthy about, blood urea concentration is found to be :
(A) 20 mg/dL
(B) 60 mg/dL
(C) 80 mg/dL
(D) 100 mg/dL
82. In anchored polymerase chain reaction (PCR), how many primers are used:
(A) 1
(B) 2
(C) 3
(D) 4
83. Which of the following Anticancer agent have the least emetogenic activity:
(A) Cisplatin
(B) Cyclophosphamide
(C) Decarbazine
(D) Hydroxyurea
84. British Antilewisite (BAL) is name of:
(A) Penicillamine
(B) Dimercaprol
(C) Deferiprone
(D) Melarsoprol
85. Which of the following do not show Albumine-protein binding
(A) Barbiturates
(B) Lignocaine
(C) NSAIDs
(D) Tolbutamide
86. The first line drug for Burkit’s lymphoma is:
(A) dauxorubucine
(B) Actinomycine-D
(C) cyclophosamide
(D) Vinblastin
87. Which of the following factors affects the volume of distribution (Vd) of drug:
(A) pKa of drug
(B) patition coefficient of drug
(C) plasma protein binding
(D) All of the above
88. Canrenone is active metabolite of:
(A) Digitoxin
(B) Spironolactone
(C) Dexamethasone
(D) Prednisone
89. Inverse agonist means:
(A) binds to receptor and produces the effect of agonist
(B) binds to receptor and opposes the effect of agonist
(C) binds to receptor and produces opposite effect of agonist
(D) binds to receptor and produces effect like antagonist
90. The genetically determined unwanted reactivity to chemicals or drugs is called:
(A) Intolerence
(B) Drug allergy
(C) Idiosyncracy
(D) Poisoning
91. Which of the following agent is used in amerlirative test of Myasthenia gravis:
(A) Eudrophonium
(B) Physostigmine
(C) Pyridostigmine
(D) Neostigmine
92. Dale’s experiment is related with:
(A) Angiotensine
(B) Serotonine
(C) Adrenaline
(D) Acetylcholine
93. Straubb reaction in rats is shown by:
(A) Ephidrine
(B) Morphine
(C) Histamine
(D) Dopamine
94. Selective α2-antagonist is:
(A) Phenoxybenzamine
(B) Clonidine
(C) Yohimbine
(D) Phentolamine
95. Auerbach’s plexues and Meissner’s plexues are present in:
(A) sympathetic system
(B) parasympathetic system
(C) enteric nervous system
(D) none
96. One IU of Insulin equals to ………. .
(A) 0.04082 mg
(B) 0.4082 mg
(C) 0.004082 mg
(D) 0.0004082 mg
97. De-Jalons method is used in the bioassay of:
(A) Insulin
(B) Digitalis
(C) Adrenaline
(D) Histamine
98. Which one of the following stimulates central trigger zone (CTZ) and induces vomiting:
(A) Hyoscine
(B) Ipecac syrup
(C) Both (A) and (B)
(D) none
99. One of the following is a Leukotriene synthatase inhibitor:
(A) Montelukast
(B) Nedocromil Sodium
(C) Ziluton
(D) Zafirlukast
100. Which one of the following Anticonvulsant acts by blocking T-type Calcium channels:
(A) Ethusuximide
(B) Iminostilbines
(C) Lemotrigine
(D) Topiramate
101. Concurrent use of loop diuretics and Streptomycin is avoided because of:
(A) Ototoxicity
(B) Nephrotoxicity
(C) Neuromuscular-blockade
(D) Agranulocytosis
102. Erythromycin acts by:
(A) combining with 50s-ribosome
(B) combining with 30s-ribosome
(C) interfering with DNA synthesis
(D) all of the above
103. Loss of visual acuity due to optic neuritis is a major side effect of:
(A) Pyrizinamide
(B) Ethambutol
(C) Rifampicin
(D) Thiacetazone
104. Polyene antibiotics are ineffective against bacteria because:
(A) unable to penetrate bacterial cell wall
(B) bacteria do not have sterol
(C) Both (A) and (B)
(D) None of the above
105. G-protein coupled receptors are located:
(A) intranuclearly
(B) in cell membrane
(C) Both (A) and (B)
(D) None of the above
106. One of the following does not show enantiomerism
(A) lactic acid
(B) isopropyl chloride
(C) chloroiodo methane sulphonic acid
(D) secondary butyl chloride
107. One of the following does not give information about the conformations of macro molecules in solution:
(A) CD
(B) ORD
(C) XRD
(D) None of the above
108. One of the following is incorrect:
(A) optical rotation is pH dependent
(B) optical rotation changes with change in solvent
(C) (S)-(+)-lactic acid is levo-rotatory in water
(D) unit of specific rotation is deg cm29
109. Torsion angles in staggered conformation is:
(A) 90°
(B) 120°
(C) 60°
(D) 45°
110. ……………… is stereomutation :
(A) racemization
(B) epimerization
(C) asymmetric transformation
(D) all of the above
111. (+)-Lactic acid is:
(A) dextro rotatory
(B) levorotatory
(C) meso
(D) achiral
112. Phospholipids are usually in:
(A) anionic form
(B) dipolar ion form
(C) non-ionic form
(D) cationic form
113. Hydroxylation of cyclopentene with KmnO4 results in:
(A) cis-1, 2-cyclopentanediol
(B) tans-1, 2-cyclopentanediol
(C) cyclopentanol
(D) all of the above
114. A substance decolourise bromine solution in CCl4 and a cold, dilute, neutral permagnet solution. The substance is:
(A) alkane
(B) alkene
(C) alcohol
(D) aldehyde
115. 
Structure is of ………… .
(A) (-) – Tartaric acid
(B) (+)-Tartaric acid
(C) Meso Tartaric acid
(D) None of the above
116. Structure of (1R, 2S)-(-)-Ephedrine is:
117. 
The reaction is:
(A) Friedel-Craft alkylation
(B) Hoffmanns reaction
(C) Witting reaction
(D) Neber reaction
118. How many isomers are possible for Menthol?
(A) 3
(B) 4
(C) 5
(D) 6
119. Hogg kidney is used in kinetic resolution of recemic mixture as a source of:
(A) Acylase 1
(B) Lipase
(C) Hydrolase
(D) None of these
120. 
is …….. -1-(1-Naphthyl) ethylisocynate:
(A) R
(B) S
(C) RS
(D) None of these
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