Pharmaceutical Science (PY) Competitive Examination-2017
(GPAT, CET, NIPER etc.)
1. An accurate clock shows the times as 30 minutes past two. The angle (in degrees) between the minute-hand and the hour-hand is:
(A) 120°
(B) 110°
(C) 105°
(D) 100°
2. If 2x + y = 10 & x + 3y = 10, then find x & y:
(A) 4 & 2
(B) 2 & 4
(C) 1 & 3
(D) 3 & 1
3. Highest number of USFDA approved pharmaceutical plants are placed in:
(A) China
(B) India
(C) Brazil
(D) None of these
4. Indian Patent Information office is situated at :
(A) Mumbai
(B) Nagpur
(C) Kanpur
(D) Bangalore
5. ‘In small bridged systems one can not have a double bond at the bridgehead position.’ This is:
(A) Prelog’s rule
(B) Bredt’s rule
(C) Markowknikoff’s rule
(D) None of the above
6. Which of the following not a positive symptoms associated with Schizophrenia?
(A) hallucination
(B) anhedonia
(C) delusion
(D) Disorganized thoughts
7. Which of the following mood stabilizer would be most appropriate in a patient with liver diseases?
(A) Lithium
(B) Valproic acid
(C) Carbamapezine
(D) None of these
8. One is not correct about following structure :
(A) It is an acid
(B) it is fenamate
(C) increases prostaglandin
(D) it is an NSAID
9. Cefepime is …….. generation cephalosporin.
(A) First
(B) Second
(C) Third
(D) Fourth
10. When radiation modulated at an acoustical frequency, is absorbed by substance. The radiation is converted in to heat. This is called as:
(A) Photoacoustic spectroscopy
(B) Optoacoustic spectroscopy
(C) Both (A) and (B)
(D) None of the above
11. Vector used in the Recombinant DNA technology is:
(A) Plasmids
(B) Cosmids
(C) Bacteriophages
(D) All of these
12. Borrelia recurrentis is s causative organism for :
(A) Plague
(B) Lyme disease
(C) Relapsing fever
(D) Dengue
13. Non-ionizing radiation used for sterilization is:
(A) UV-rays
(B) X-rays
(C) γ-rays
(D) Cosmic rays
14. Identification of specific RNA is done by:
(A) Southern blot
(B) Northern blot
(C) Western blot
(D) All of these
15. Deposition of enzyme on the carrier by applying electric current is called as:
(A) Electrophoresis
(B) Electroporation
(C) Electrodeposition
(D) Electrotransformation
16. Polyacrylamide gel is used as material in which tenchique of immobilization:
(A) Covalent binding
(B) Adsorption
(C) Entrapment
(D) Complexation
17. Radioallergosorbent test is related to ……… antibody.
(A) IgE
(B) IgM
(C) IgA
(D) IgD
18. Pseudomonas dentrificans is a source of:
(A) Riboflavin
(B) Vitamin B12
(C) Ascorbic acid
(D) Amino acid
19. In the fermentation process, animal or vegetables lipids are used as:
(A) Antifoaming agent
(B) Inhibitor of unwanted metabolic process in lack of O2
(C) Source of carbon
(D) pH maintaining agent
20. Bohrs effect is related to:
(A) Lipids
(B) Plasma protein
(C) Hemoglobin
(D) Vitamins
21. One of the following vitamin is known as harmone:
(A) Vitamin D
(B) Vitamin A
(C) Vitamin C
(D) Vitamin E
22. In nucleotide replacement, the phenomenon in which purine is replaced by pyrimidine & vice versa called as:
(A) Transition
(B) Transversion
(C) Rearrangement
(D) Exchange
23. Rapid amplification of DNA segment is called as:
(A) General recombination
(B) PCR
(C) gene expression
(D) Blotting technique
24. In cell culture, the phase in which cells dies is :
(A) Lag phase
(B) Exponential phase
(C) Linear phase
(D) Senescent phase
25. Icterus index is used to determine:
(A) Serum albumin
(B) Urine albumin
(C) Serum bilirubin
(D) Urine bilirubin
26. Carboxyhemoglobin is formed by binding of hemoglobin with :
(A) CO
(B) CO2
(C) CHO
(D) COOH
27. ETC is located at :
(A) Inner mitochondrial membrane
(B) Outer mitochondrial membrane
(C) Intermembranous space
(D) Mitochondrial matrix
28. Removal of one carbon atom from lipid occurs in:
(A) β-oxidation
(B) α-oxidation
(C) ω-oxidation
(D) All of these
29. In tissue culture, surface sterilization of explants is done by:
(A) Distilled water
(B) Methanol
(C) Sodium hypochlorite
(D) Propiolactone
30. Ornithin amino acid can never found in protein structure because :
(A) Inability to form peptide bond
(B) Due to lack of zwitterions formation
(C) Due to lack of codone
(D) Due to structural dissimilarity
31. Lesch-Nyhan syndrome is due to the deficiency of:
(A) Hypoxanthin-guanine phosphoribosyltransferase
(B) Formyltransferase
(C) Adenine-phosphoribosyltransferase
(D) Cyclohydrolase
32. One of the following phospholipid possesses antigenic properties :
(A) Lecithin
(B) Cephaline
(C) Cardiolipin
(D) Plasmalogens
33. Catalytic activity of enzyme is lost by :
(A) Extreme pH
(B) Extreme temperature
(C) Denaturating agent
(D) All the above
34. Three dimensional structure of a protein & the relative stereochemical position of its atom determined by :
(A) X-ray crystallography
(B) IR-spectroscopy
(C) ESR
(D) All the above
35. Aldolase enzyme belongs to class :
(A) Transferase
(B) Lyase
(C) Ligases
(D) Hydrolase
36. In un-compitative inhibition, inhibitors mainly binds to :
(A) Enzyme
(B) Substrate
(C) Enzyme & enzyme-substrate complex
(D) Enzyme-substrate complex
37. 1 IU of enzyme is equal to ………………
(A) 40 μ ketal
(B) 50 μ ketal
(C) 60 μ ketal
(D) 70 μ ketal
38. Mannitol is :
(A) Polyhydroxy alcohol
(B) Monosachharides
(C) Both (A) & (B)
(D) None
39. How many grams of menthol should be used to prepare this prescription containing 0.8% Menthol & Alcohol sq. 60.00 ml ?
(A) 0.48 g
(B) 0.8 g
(C) 4.8 g
(D) 1.48 g
40. “In dehydrohaloganation the more stable the alkene, the faster it is formed” This is :
(A) Saytzeffs rule
(B) Walden inversion
(C) Tollens reaction
(D) None of the above
41. Starting product of Sandmeyer reaction is :
(A) alkynes
(B) Diazonium salts
(C) o-toludine
(D) None of these
42. 
These are ………………
(A) Diastereomers
(B) Enantiomers
(C) Confirmational isomer
(D) Bioisomer
43. ………. is a phase transfer catalyst.
(A) crown ether
(B) AlCl3
(C) Both (A) & (B)
(D) None of these
44. 
The reaction follows :
(A) Kharasch rule
(B) Markovnikov rule
(C) Bredt rule
(D) None of these
45. Perkin condensation yields :
(A) Unsaturated acids
(B) Saturated acids
(C) Unsaturated ketones
(D) Unsaturated aldehydes
46. 
(A) 2
(B) 3
(C) 5
(D) no
47. 
are …………..
(A) Confirmational isomer
(B) Enantiomers
(C) Distereomers
(D) None of these
48. Nitrogen rule is used in the interpretation ……… spectra.
(A) IR
(B) NMR
(C) Mass
(D) ESR
49. CDRI is located at :
(A) Lucknow
(B) Kassuli
(C) Itanagar
(D) Chandigarh
50. GRAS is related to :
(A) Safety
(B) Stability
(C) reactivity
(D) None of these
51. Minister of chemical & Fertilizers Govt. of India is:
(A) A. K. Antony
(B) Ramvilasa Paswan
(C) Sharad Pawar
(D) Prafful Patel
52. The synonym of abduct :
(A) Confined
(B) Bound
(C) Released
(D) absolve
53. The antonym of Equivocate :
(A) Distinguish
(B) Pledge
(C) Yields
(D) Vary
54. Coulter counter works on the principle of :
(A) electric resistance
(B) light diffraction
(C) light transmission
(D) light absorption
55. Standard deviation is :
(A) square of variance
(B) square root of variance
(C) square of difference between observation and mean
(D) None of the above
56. Guedels sign of anesthesia are based on effect of :
(A) Diethyl ether
(B) Thiopental
(C) Ketamine
(D) Fentanyl
57. Browning of vision due to retinal deposit is caused by :
(A) Thioridazone
(B) Clozapine
(C) Haloperidol
(D) Ariprazole
58. Dihydroorotate dehydrogenase inhibitor used as DMARDs is:
(A) Methotrexate
(B) Leflunomide
(C) Azathioprine
(D) Cyclosporine
59. Vaughan Williams classification system classify drug used in :
(A) Parkinsonism
(B) Arrhythmia
(C) Huntington’s diseases
(D) None of these
60. G-Proteins are …………….
(A) Tetrameric
(B) Bimeric
(C) Trimeric
(D) Pentameric
61. One of the following lipoprotein increases in type IV hyperlipidemia:
(A) LDL
(B) HDL
(C) VLDL
(D) Chylomicron
62. …………..measure the absorption & urninary excretion of radiolabled Vitamin B12
(A) Carr test
(B) Schilling test
(C) Icterus index
(D) None of these
63. Which of the following antiviral drug used as Antiparkinsonian agent :
(A) Zidovudine
(B) Amantadine
(C) Foscarnet
(D) None of these
64. Selective MAO-B inhibitor is:
(A) Clogyline
(B) Moclobemide
(C) Tranylcypromine
(D) Selegilline
65. Phosphodiesterase inhibitor used as Antiplatelate agent is :
(A) Amrinone
(B) Dipyridamol
(C) Ticlopidine
(D) Aspirin
66. Antimetic agent used during the cancer treatment is :
(A) Promethazine
(B) Metoclopramide
(C) Odensetron
(D) Cinnarizine
67. SMON Syndrome is related to :
(A) Metronidazole
(B) Diloxanide furoate
(C) Quiniodochlor
(D) Tetracycline
68. Cardiotoxicity is side effect of one of the following anticancer agent :
(A) Dactinomycin
(B) Doxorubicin
(C) Bleomycin
(D) Mitomycin
69. Macrolide derivative that used as Immunosuppresent is :
(A) Cyclosporin
(B) Tracolimus
(C) Basiliximab
(D) All of these
70. Hepatotoxicity is major side effect of followings drugs except:
(A) Ethambutol
(B) Isoniazide
(C) Rifampicin
(D) Pyrazinamide
71. All the following drugs acts better in acidic urine except :
(A) Nitrofurantoin
(B) Methanamine
(C) Cloxacillin
(D) Gentamicin
72. All the following macrolide derivatives are stable in acid except:
(A) Azithromycin
(B) Clarithromycin
(C) Roxithromycin
(D) Erythromycin
73. Drug of choice for motion sickness is :
(A) Cinnarizine
(B) Chlorpromazine
(C) Prochlorperazine
(D) Haloperidol
74. Plasma expander is:
(A) Dextrans
(B) Human Albumin
(C) Hetastarch
(D) All of these
75. All of the following are prodrug except:
(A) Lisinopril
(B) Enalapril
(C) Perindopril
(D) Ramipril
76. Competitive antagonist at GABAA receptor is :
(A) Muscimol
(B) Bicuculline
(C) Flumazenil
(D) Picrotoxin
77. Class II Antiarrhythmic drugs…………….
(A) Slows phase 0 depolarization
(B) Suppress phase 4 depolarization
(C) Shorten phase 3 depolarization
(D) Prolong phase 3 depolarization
78. Mechanism of Antimanic drug Lithium is:
(A) Decreases the release of NA & DA
(B) Li+ partly replace Na+ & affect ionic fluxes across brain cell
(C) Inhibit Inositol-1-phospate T reduces supply of Inositol for regeneration of brain membrane
(D) All the above
79. Mianserin, Antidepressants agent acts by:
(A) Inhibiting NA & 5-HT uptake
(B) Blocking presynaptic α2 receptor
(C) Inhibiting NA & DA uptake
(D) All the above
80. All of the following true about Calcitonin except
(A) Inhibits phosphate tubular reabsorption from kidney
(B) Inhibits resorption of Ca from bone
(C) Inhibits Ca tubular reasbsorption from kidney
(D) Increases resorption of Ca from bone
81. A Grignard reagent does not react with ketones with bulky group but an………reagent reacts successfully with ketones with bulky groups.
(A) organolithium
(B) phosphonate
(C) Both (A) & (B)
(D) None of the above
82. Stereospecific reaction of dimethyl maleate with butadiene yields cis-dimethyl cyclohexene-4, 5-dicarboxylate. This is………… reaction.
(A) Claisen
(B) Diels-Alder
(C) Hoffmann
(D) None of these
83. Pericyclic reactions are concerted, unaffected by catalyst or solvents & have ….. transition states.
(A) acyclic
(B) cyclic
(C) both (A) & (B)
(D) None of these
84. Sodium boronhydride is chemoselective. It does not reduce :
(A) esters
(B) ketones
(C) aldehydes
(D) acid chlorides
85. All protein amino acids belong to …………series.
(A) L
(B) D
(C) DL
(D) None of these
86. Exchange of pair of groups around a sterocentere gives a different :
(A) configurational isomer
(B) stereoisomer
(C) Both (A) and (B)
(D) None of the above
87. 
88. …..stereoisomers are possible in 2,3-dibromobutane.
(A) 4
(B) 2
(C) No
(D) 3
89. Water has ………. axis of symmetry.
(A) C3
(B) C4
(C) no
(D) C2
90. Troger’s base is:
(A) chiral
(B) achiral
(C) can not say
(D) Both (A) & (B)
91. 
This is chair conformation of cyclohexane, It has……..
(A) S6 axis
(B) S3 axis
(C) center
(D) All these
92. 
These structures are:
(A) all equivalent (R)
(B) all equivalent, (S)
(C) first two equivalent
(D) last two equivalent
93. 
One of the following is correct:
(A) Pair A : Homomers, Pair B: Diastereomers
(B) Pair A : Diastereomers, Pair B : Diastereomers
(C) Pair A : Homomers, Pair B : Homomers
(D) Pair A : Diastereomers, Pair B : Diastereomers
94. 
This sulfoxide is:
(A) (S)
(B) (R)
(C) not chiral
(D) symmetrical
95. (S)-(+)-2-bromobutane when exposed to bromide ion in acetone is racemized due to……….SN2
(A) irreversible
(B) reversible
(C) stereoselective
(D) no
96. The activation energy for cyclohexane ring inversion (rapid process) is……kcal/mol.
(A) 10.8
(B) 3.8
(C) 20
(D) 40
97. Lithium aluminium hydride reduction of 4-t-butyl-cyclohexanone gives……alcohol.
(A) axial
(B) equatorial
(C) no
(D) Both (A) & (B)
98. Witting reaction is………..regioselective.
(A) completely
(B) not
(C) partially
(D) None of these
99. Most of the protein amino acids have S-configuration except:
(A) L-Alanine
(B) L-Proline
(C) L-Cysteine
(D) L-Serine
100. N-acyl-L-amino acids are……….molecules.
(A) heterochiral
(B) homochiral
(C) Both (A) & (B)
(D) None of the above
101. The allenes of the type abC = C = Cab are……….due to non planar arrangement of our groups called a chiral………. .
(A) chiral, axis
(B) achiral, axis
(C) chiral, point
(D) achiral, point
102. 
This is……….reaction.
(A) Reformatsky
(B) Perkin
(C) Mannich
(D) Knoevenagel
103. Asymmetric synthesis yields?
(A) one enantiomer predominantly
(B) one distereomer predominantly
(C) Both (A) & (B)
(D) 50% mixtures of both stereomers
104. MESNA is used to relieve the side effects of….. .
(A) methotrexate
(B) cyclophosphamide
(C) hydroxyurea
(D) 5-fluorouaracil
105. Cisplatin acts by inhibiting…………… .
(A) DNA polymerase
(B) DNA gyrase
(C) RNA polymerase
(D) All of the above
106. Acyclovir is widely used in treatment of :
(A) HIV
(B) Polio
(C) genital herpes simplex
(D) varicella zoster infection
107. One of the following vitamin is used along with isoniazide:
(A) riboflavin
(B) pyridoxine
(C) thiamine
(D) niacin
108. The major side effect of metformin is:
(A) lactic acidosis
(B) agranulocytosis
(C) hypoglycemia
(D) renal failure
109. One of the following antidiabetic is not hypoglycemic, but it is antihyperglycemic:
(A) Glipizide
(B) Glibenclamide
(C) Tolbutamide
(D) Metformin
110. One of the following H2 antagonist contains furan ring:
(A) cimetidine
(B) famotidine
(C) ranitidine
(D) nizatidine
111. A synonym of decorous is :
(A) momentary
(B) emotional
(C) suppressed
(D) proper
112. A antonym of hallow is :
(A) keep silence
(B) desecrate
(C) instigate
(D) prove incorrect
113. If two or more dosage forms contain the same labeled quantities of the same drug, then it is called as:
(A) bioequivalence
(B) chemical equivalence
(C) clinical equivalence
(D) therapeutic equivalence
114. The drug which is resistant to biotransformation is called:
(A) soft drug
(B) hard drug
(C) prodrug
(D) None of the above
115. The scheduled indicating list of minimum equipments for efficient running of a pharmacy is:
(A) M
(B) P
(C) N
(D) R
116. S-H stretching region in IR is:
(A) 2600-2550 cm−1
(B) 2400-2220 cm−1
(C) 1600-1400 cm−1
(D) 1070-1030 cm−1
117. NaCl is titrated by:
(A) redox titration
(B) argentometric titration
(C) iodometry
(D) acid base titration
118. Dropping mercury electrode is used in:
(A) amperometry
(B) potentiometry
(C) polarography
(D) conductometry
119. CDRI is located at:
(A) Kanpur
(B) Kolkata
(C) Lacknow
(D) Kasauli
120. Preparation of plate in TLC is done by:
(A) pouring
(B) dipping
(C) spraying
(D) All of the above
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