IB 13

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1809 – MOLECULAR BIOLOGY

 

 

 

Date : 08-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION –A

Answer ALL the following.                                                                                 (10 x 2 = 20 marks)

1. Expand a) ASR b) CPT   c) ABCC   d) TWGDAM.
2. What is RNA polymerase holoenzyme?
3. Define chargaff’s rule of molar equivalence.
4. Differentiate poly glutamine from non-poly glutamine disease.
5. What are the clinical symptoms of xeroderma pigmentosum?
6. Distinguish cisterns from crista.
7. Define nucleic acid hybridization.
8. Mention the role of catalase and oxidase in peroxisomes.
9. What are the rare forms of sickle cell disease?
10. Distinguish oncogenes from proto-oncogenes

 

SECTION – B

Answer any FOUR of the following.                                                                (4 x 10=40 marks)

11. Explain the models of plasma membrane.
12. Give an account on cytoskeleton, cilia, flagella and ribosome.
13. Describe genetic code.
14. Describe in detail the structure of DNA and the separation of strands.
15. Give an account on the functional elements of chromosomes.
16. Explain the translocation of mutation in Chronic myelogenous leukemia, Burkitt’s lymphoma and Wilm’s tumor.

 

SECTION – C

Answer any TWO of the following.                                                                  (2 x 20=40 marks)

17. Explain the mechanism of replication.
18. With a neat flow chart for establishing the molecular diagnostic laboratory, explain Laboratory design and Laboratory personnel.
19. What are syndromes? Explain Duchenne muscular dystrophy and Prader – willi syndrome.
20. Describe the types of gene mutations

 

 

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