Pharmaceutical Science (PY) Competitive Examination-2016
(GPAT, CET, NIPER etc.)
1. D-(+) Glyceraldehyde is:
(A) R
(B) S
(C) RS
(D) None of these
2. Reduction of alkene with ………..yields predominantly trans-alkene:
(A) sodium in liquid NH3
(B) Lindlar catalyst
(C) specially prepared palladium
(D) All of the above
3. Benzene does not show reaction with:
(A) HI
(B) HNO3/H2SO4
(C) Cl2/Fe
(D) Br2/Fe
4. Hydrolysis of glycerides yields:
(A) salts of fatty acids
(B) Glycerol
(C) Soap
(D) All of these
5. Addition of HBr to 1-Butene yields 2-Bromobutadiene. The sp2 carbon of butane is called :
(A) Enantioselective
(B) Enatiotopic
(C) Enantiotropic
(D) None of these
6. Racemization during peptide synthesis can be suppressed by adding:
(A) weak acid
(B) weak base
(C) strong acid
(D) strong base
7. Biosynthesis of amino acid in most living cell produces material having :
(A) D-configuration
(B) L-configuration
(C) DL-configuration
(D) None of these
8. Example of metabolically inert tissue:
(A) Tooth enamel
(B) Eye lens
(C) Both (A) & (B)
(D) None of these
9. Select the correct :
(A) Propionic acid-Prochiral center
(B) (S)-lactic acid-Chiral center
(C) Pyruvic acid-Prochiral center
(D) All of the above
10. Anisochrony means:
(A) Difference in chemical shift
(B) Difference in electric potential
(C) Difference in coupling constant
(D) None of the above
11. One statement is incorrect:
(A) Enantiotopic nuclei are isochronous in achiral media
(B) Diastereotopic nuclei are anisochronous
(C) Enantiotopic nuclei are anisochronous in achiral media
(D) Detection of distereotopic nuclei by NMR is independent of temperature
12. E2 elimination is:
(A) Stereoselective
(B) Stereospecific
(C) Both (A) and (B)
(D) None of the above
13. Threo-3-Chloro-2-butanbol is:
(A) Dextro-enatiomer
(B) Levo-isomer
(C) Both (A) & (B)
(D) None of the above
14. Reaction of formaldehyde with Grignard reagent yields:
(A) Tertiary alcohol
(B) Secondary alcohol
(C) Primary alcohol
(D) All of these
15. 
(A) Diastereomers
(B) Anomers
(C) Both A & B
(D) None of these
16. Azithromycin is prepared by ………rearrangement.
(A) Beckmann
(B) Hoffman
(C) Lossen
(D) All of these
17. Acyclovir is most widely used in the treatment of:
(A) Genital Herpes simplex
(B) HIV
(C) Sarcoma
(D) Influenza
18. Quinidine sulphate is a………….of quinine.
(A) Levorotatory Diastereomer
(B) Dextrorotatory Diastereomer
(C) Enantiomer
(D) None of the above
19. 
this is:
(A) Curtius rearrangement
(B) Hofmann rearrangement
(C) Lossen rearrangement
(D) None of the above
20. Synthesis of carboxylic acids by ………. increase the length of carbon chain:
(A) Grignard synthesis
(B) Nitrile synthesis
(C) Both (A) & (B)
(D) None of these
21. ……….. is a non reducing sugar:
(A) Glucose
(B) Fructose
(C) Sucrose
(D) All of these
22. Anomers are also:
(A) Diastereomers
(B) Enantiomers
(C) Both (A) & (B)
(D) All of these
23. Glimepiride & Glipizide are similar except their:
(A) Glimepiride-Pyrazine
(B) Glimepiride-Pyrrolidine
(C) Glipizide-Pyrrolidine
(D) None of the above
24. 
(A) Trans
(B) Cis
(C) Guache
(D) Eclipsed
25. One of the following is not Xanthine alkaloid:
(A) Caffiene
(B) Theophyline
(C) Theobromine
(D) Amphetamine
26. Carr Price reaction of vitamin A gives:
(A) Intense blue
(B) Intense violet
(C) Intense Green
(D) Intense red
27. One of the following is Benzothiazepine calcium channel blocker:
(A) Verapamil
(B) Nifedipine
(C) Biperidile
(D) Diltiazem
28. ………….is the suitable candidate for Bucoadhesive drug delivery system.
(A) Nitroglycerin
(B) Verapamil
(C) Propranolol
(D) All of these
29. Find out incorrect pair:
(A) stomach pH 1-3
(B) skin pH 4-5
(C) saliva pH 6-7
(D) tears pH 6-7
30. The most stable conformation of Acetylcholine is:
(A) Trans
(B) Guache
(C) Eclipsed
(D) All of these
31. One of the following is long acting Insulin preparation:
(A) Insulin zinc suspension
(B) Globin zinc insulin suspension
(C) Protamine zinc insulin suspension
(D) Isophane insulin suspension
32. Nano car was designed by TATA motors at :
(A) Pune
(B) Nandigram
(C) Gudgaon
(D) Chandigarh
33. CrocinTM is a product of:
(A) Glaxosmithkline
(B) Pfizer
(C) Medi Nova
(D) Torent
34. Pethidine is used in:
(A) obtaining pleasure
(B) Euphoria
(C) Parkinsonism
(D) Aneasthesia
35. ………… is a triabasic acid.
(A) CH3COOH
(B) H2SO4
(C) H3PO4
(D) None of these
36. Vodaka is an alcoholic beverage obtained from fermentation of:
(A) Potato
(B) Apple
(C) Rice
(D) All of these
37. One of the following great names is related with Magic bullet:
(A) Pasteur
(B) Ehrlich
(C) Sorenson
(D) A. Fleming
38. A cake of round shape has to be divided in three straight strokes by a knife. How many maximum slices can be obtained?
(A) 7
(B) 8
(C) 6
(D) 9
39. Population of 1 billion grows by 1% each year. How many years does it take to grow approximately double its present size?
(A) 10
(B) 100
(C) 50
(D) 200
40. Find the next number in the series: 2, 5, 10, 17, 26:
(A) 35
(B) 38
(C) 39
(D) 37
41. …………. is a measure of central tendency.
(A) Mean
(B) Mode
(C) Median
(D) All of these
42. Find the missing number 24: 15 : : 63: ?
(A) 56
(B) 38
(C) 48
(D) 28
43. Bloch & Purcell won the Nobel prize of 1952 for their contribution in…………
(A) NMR
(B) IR
(C) DSC
(D) Chromatography
44. Densitometry is used in:
(A) GCIR
(B) TLC
(C) GLC
(D) All of these
45. Beer-Lambert’s law is applied in:
(A) UV-Visible spectroscopy
(B) IR-spectroscopy
(C) Both (A) & (B)
(D) None of these
46. ………….gas is used in Hollow cathode discharge lamp.
(A) Helium
(B) Neon
(C) Argon
(D) All of these
47. ………………is called as vibrational spectroscopy.
(A) IR
(B) UV-Visible
(C) ESR
(D) NMR
48. Column coupling HPLC is also known as ……….chromatography
(A) Column back flushing
(B) Boxcar
(C) Filtration
(D) None of the above
49. Nernst distribution law is related to:
(A) Partition coefficient
(B) Oxidation potential
(C) Reduction potential
(D) None of the above
50. …………. amino acid shows fluroscence.
(A) Glycin
(B) Tryptophan
(C) Cystein
(D) Serine
51. …………..plating is used in GC-IR to increase the effective pathlenth of IR cell.
(A) Gold
(B) Stainless steel
(C) Chromium
(D) None of these
52. Resolution of HPLC can be modified by:
(A) Decreasing particle size
(B) Decreasing column diameter
(C) Changing flow rate
(D) All of the above
53. One of the following is universal HPLC detector:
(A) IR
(B) UV-Visible
(C) Refractive index
(D) All of these
54. Solvent shift in UV-Visible spectroscopy is related with:
(A) Boiling point of solvent
(B) Polarity of solvent
(C) Molecular weight of solvent
(D) None of the above
55. 1μg is equal to………..
(A) 10−6 mg
(B) 106 mg
(C) 10−9 mg
(D) 109 mg
56. …………….. is a standard used in mass spectroscopy.
(A) TMS
(B) DSS
(C) PFK
(D) None of these
57. Henry-Moslehy relationship is related to:
(A) UV-Visible spectroscopy
(B) IR spectroscopy
(C) X-ray diffraction
(D) NMR
58. One of the following statements is incorrect
(A) Polarimetry & polarography are the same
(B) Current remains constant in polarimetry
(C) 0.1 N HCL solution is present in glass electrode
(D) Electral powder can be analyzed by flame photometry
59. Compatibility of drug with excipients can be studied by:
(A) DSC
(B) Atomic absorption spectroscopy
(C) UV-Visible spectroscopy
(D) None of the above
60. Conjugation in a molecule increases:
(A) Absorptivity
(B) Extinction coefficient
(C) Molar absorptivity
(D) All the above
61. Normality of concentrated HCl is approximately:
(A) 1.7 N
(B) 17 N
(C) 35 N
(D) None of these
62. Most of the drugs in the USP are assayed by:
(A) IR spectroscopy
(B) NMR
(C) UV-Visible spectroscopy
(D) Chromatography
63. Headspace analysis is done by:
(A) GC
(B) HPLC
(C) HPTLC
(D) None of these
64. Gastric residence time of a dosage form can be studied by:
(A) X-ray crystallography
(B) γ-Scintigraphy
(C) Both (A) & (B)
(D) None of the above
65. Mylar film is used in instrumentation of:
(A) NMR
(B) FTIR
(C) Polarimeter
(D) None of these
66. Control of pressure is important in:
(A) UV-Visible Spectrometry
(B) Mass Spectrometry
(C) NMR
(D) IR Spectrometry
67. If mobile phase or stationary phase in HPLC is chiral, then:
(A) Enantiomers can be separated
(B) Enantiomers can not be separated
(C) Flow rate is to be reduced
(D) Guard column can be used
68. Cyclohaxane shows ……………. NMR spectra at temperature 25°C & −40°
(A) same
(B) different
(C) no
(D) None of these
69. Analytical technique useful in evaluation of Aerosols:
(A) IR
(B) GC
(C) Both (A) & (B)
(D) None of these
70. Hooke’s law is a basis for:
(A) X-ray diffraction
(B) IR spectroscopy
(C) NMR
(D) Gravinmetry
71. EDTA is :
(A) Hexadentate
(B) pentadentate
(C) heptadentate
(D) tetradentate
72. ICH guidelines are related to:
(A) Analytical method validation
(B) Stability studies of tablets
(C) Stability studies of SR tablets
(D) All of these
73. Hydrogen bonding interactions between two polymers can be studied by:
(A) IR spectroscopy
(B) Mass spectrometry
(C) X-ray diffraction
(D) None of the above
74. LASER means:
(A) Light amplification by stimulated excitation of radiation
(B) Light attenuation by stimulated excitation of radiation
(C) Light amplification by simulated excitation of radiation
(D) Light attenuation by simulated excitation of radiation
75. Validation of analytical method considers:
(A) Accuracy
(B) Cost effectiveness
(C) Both (A) & (B)
(D) None of these
76. Pharmacy practice is related with:
(A) Patient counseling
(B) Dispensing
(C) Inventory control
(D) All of these
77. Correlation coefficient is 0.98. It means there is…………. correlation.
(A) no
(B) good
(C) worst
(D) bad
78. C-O stretching is indicated in IR spectra in the range of:
(A) 1650-1790 cm−1
(B) 2360-2450 cm−1
(C) 990-1100 cm−1
(D) 3310-3540 cm−1
79. Synonym of silently angry is:
(A) sulk
(B) siesta
(C) surfeit
(D) None of these
80. Ajar means…………..
(A) tightly closed
(B) slightly open
(C) open
(D) stop
81. Directed movement of a cell or organism toward (or away from) a chemical source is called:
(A) chemotaxis
(B) chemodomes
(C) both (A) & (B)
(D) None of these
82. ……….. elect the president of India.
(A) Loksabha
(B) Rajyasabha
(C) People of India
(D) Members of Parliament & state assemblies
83. Volume of sphere =
(A) 
(B) 
(C) 
(D) 
84. Find the mean & mode of : 2, 6, 3, 3, 4, 1, 3, 10:
(A) 4 & 3
(B) 3 & 4
(C) 3 & 3
(D) 4 & 4
85. The concept of pH was given by :
(A) Lewis
(B) Sorensen
(C) Newton
(D) None of the above
86. NiceTM is a product of :
(A) Ranbaxy
(B) Cipla
(C) Dr. Reddys
(D) Lupin
87. Blue ship is left to red, red ship is left to green, if blue & green ship changes its position then:
(A) blue is between red & green
(B) red is between green & blue
(C) green is between red & blue
(D) red is right to green
88. Which one of the following city in India is known as “Pink city”?
(A) Jodhpur
(B) Nagpur
(C) Jaipur
(D) Kanpur
89. Cryoscopic constant is related to:
(A) Freezing point depression
(B) boiling point elevation
(C) melting point
(D) vapour pressure
90. Dosator is used in manufacturing of ……..
(A) tablets
(B) capsules
(C) aerosols
(D) ointments
91. Anticoagulant of Choice during pregnancy is :
(A) heparin
(B) warfarin
(C) dicumarol
(D) All of these
92. One of the following is HMG-COA reductase inhibitor.
(A) clofibrate
(B) colestipol
(C) pravastatin
(D) probucol
93. Opoid rotation is used in the treatment of :
(A) cancer pain
(B) acute pain
(C) aneasthesia
(D) None of these
94. Quantal assay means:
(A) graded response assay
(B) crossover test
(C) matching assay
(D) All or none response
95. Mode of action of methotrexate is:
(A) Inhibits dihydrofolate reductase inhibitor
(B) inhibits protein synthesis
(C) inhibits glucose uptake
(D) All the above
96. Adriamycin is name of:
(A) daunorubicine
(B) doxorubicine
(C) dactinomycin
(D) bleomycin
97. One of the following form of mevalonic acid is responsible for synthesis of rubber:
(A) R-cis
(B) R-trans
(C) S-cis
(D) S-trans
98. Carotenoids are biosynthesized from:
(A) geranyl phosphate
(B) fernasyl phosphate
(C) squalene
(D) isoprene
99. L-(+)-pseudoephedrine is…….,……diastereomerisomer of ephedrine.
(A) S, S
(B) R, S
(C) R, R
(D) S, R
100. Shortening or lengthening the chain of atoms that separates the ester group form the onium moiety decreases:
(A) nicotinic activity
(B) muscarinic activity
(C) both (A) & (B)
(D) not have significant effect
101. The structure of metaraminol is:
102. One of the following is selective β1-blocker:
(A) propranolol
(B) atenolol
(C) timolol
(D) sotalol
103. Roam is the capital of :
(A) Sweden
(B) Italy
(C) Germany
(D) Netherland
104. CRO stands for:
(A) clinical research organization
(B) contract research organization
(C) clinical research officer
(D) contract research officer
105. Synthetic menthol is present in:
(A) l-form
(B) d-form
(C) racemic mixture
(D) none of these
106. The gauche conformer of histamine does not acts on:
(A) H1
(B) H2
(C) both (A) & (B)
(D) none of these
107. Sieve number represent the number of opening per :
(A) centimeter
(B) millimeter
(C) inch
(D) foot
108. HLB values for wetting agent is between :
(A) 1-3
(B) 4-6
(C) 7-9
(D) 13-15
109. pH of human tears is near about:
(A) 5
(B) 7.2
(C) 3.5
(D) 6.4
110. OROS device is based on the mechanism of:
(A) solubilization
(B) diffusion
(C) osmosis
(D) erosion
111. Antidandruff agent used in shampoo is:
(A) selenium sulphide
(B) polyphosphates
(C) lauryl sulphate
(D) citric acid
112. Hausner ratio is calculated by:
(A) tapped density/poured density
(B) poured density/tapped density
(C) bulk density/true density
(D) bulk volume/void volume
113. The concentration of PVP as a binder is:
(A) 1-5%
(B) 2-15%
(C) 0.5-3%
(D) 0.1-0.5%
114. In spontaneous emulsification process, emulsion are formed without:
(A) emulsifier
(B) external agitation
(C) both (A) & (B)
(D) none of the above
115. One of the following is non-ionizing solvent:
(A) ether
(B) DMF
(C) DMSO
(D) CH3CN
116. A high concentration of nucleophile favours an ……..reaction.
(A) SN1
(B) SN2
(C) both (A) & (B)
(D) none of these
117. Hydroxylation fumaric acid with osmium tetroxide yields:
(A) meso-tartaric acid
(B) (+)-tartaric acid
(C) (-)-tartaric acid
(D) (±)-tartaric acid
118. Reaction of an organozinc compound via the enolate with an aldehyde or ketone is ……….reaction.
(A) Reformatsky
(B) Claisen
(C) Witting
(D) Aldol
119. BBN means:
(A) 9-bromobicyclo[3, 3, 1] nonane
(B) 9-bromobicyclo [4, 4, 1] nonane
(C) 10-bromobicyclo [3, 3, 1] nonane
(D) 10-bromobicyclo [4, 4, 1] nonane
120. A three component reaction which binds an aldehyde, an amide & an hydrogen. The reaction is:
(A) Witting
(B) Mannich
(C) Perkin
(D) None of the above
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