Pharmaceutical Science (PY) Competitive Examination-2015
(GPAT, CET, NIPER etc.)
1. Which of the following drug is not given by sublingual rout?
(A) Methylestosterone
(B) Isoprenaline
(C) Clonidine
(D) Aminophyline
2. Rate limiting enzyme in the catecholamines synthesis is:
(A) DOPA decarboxylase
(B) N-methyl transferase
(C) Dopamine β-Hydroxalase
(D) Tyrosine hydroxlase
3. Which of the following drug has the shortest half life?
(A) Pindolol
(B) Esmolol
(C) Timolol
(D) Nadolol
4. Histamine is not absorbed orally because ………. .
(A) it is acid labile
(B) it is not absorbed through GIT
(C) it polymerizes in basic environment
(D) liver degrades it after absorption
5. One of the following is not the action of Diflunisal.
(A) Antipyretic
(B) Anti-inflammatory
(C) Analgesic
(D) Antiplatlate
6. One of the following statement is false:
(A) Somatostatin inhibits the release of insulin.
(B) Insulin inhibits glucagon secretion.
(C) Glucagon evokes release of insulin.
(D) Somatostatin increases release of glucagons.
7. ………… is most prone to produce cardiac arrhythmias.
(A) Isoflurane
(B) Halothane
(C) Enflurane
(D) NO2
8. Selective 5-HT4 agonist is…………. .
(A) Renzapride
(B) Sumatriptan
(C) LSD
(D) Buspirone
9. Which of the following is not selective COX−2 inhibitor?
(A) Meloxicam
(B) Celecoxib
(C) Rofecoxib
(D) Valdecoxib
10. Major side effect of Auranofin, a Gold compound is …….. .
(A) Diarrhea
(B) Flatulence
(C) Anemia
(D) Alopecia
11. ………… is not mucolytic agent.
(A) Pholcodein
(B) Carbocisteine
(C) Ambroxol
(D) Bromohexine
12. Octreotide is a synthetic derivative of……… .
(A) prolactin
(B) somatostatin
(C) insulin
(D) glucagon
13. Cosyntropin test is used to determine………… .
(A) acetylcholine insufficiency
(B) adrenal insufficiency
(C) thyroid insufficiency
(D) parathyroid insufficiency
14. ………. is inverse agonist of benzodiazepine.
(A) Muscimol
(B) β-carbolines
(C) Flumazenil
(D) Picrotoxin
15. When a person is suffering from hypertension along with dry cough, most preferred treatment is …….. .
(A) Captopril
(B) Losartan
(C) Furosemide
(D) Hydralazine
16. Most preferred drug for peit mal seizures is …….. .
(A) Carbamazepine
(B) Ethosuximide
(C) Primidone
(D) Valproic acid
17. Which one of the following is the most common side effect of antihyperlipidemic drugs?
(A) Increase in B.P.
(B) GIT disturbances
(C) Headache
(D) Liver disturbances
18. Class III antiarrhythmic agents are ……… .
(A) Na+ channel blocker
(B) K+ channel blocker
(C) Na+ channel opener
(D) K+ channel opener
19. Which of the following angina is not relived by Nitroglycerine?
(A) Stable
(B) Unstable
(C) Variant
(D) Prinzmental
20. Sulphonamide inhibits mainly …………. .
(A) folate synthetase
(B) folate reductase
(C) cell wall synthesis
(D) DNA synthesis
21. Nalidixic acid should not be given concurrently with …….. .
(A) Atropine
(B) Nitrofruantoin
(C) Streptomycine
(D) Trimethoprim
22. Red man syndrome is a side effect of ……… .
(A) Lincomycin
(B) Vanomycin
(C) Clindamycin
(D) Spiramycin
23. …………… acts as urinary analgesic.
(A) Nitrofurantoin
(B) Methanamine
(C) Phenazopyrodine
(D) Nalidixic acid
24. ……… is a antileprotic agent chemically related to sulphonamide.
(A) Clofazime
(B) Dapsone
(C) Ethionamide
(D) Isoniazide
25. Major toxicity of Foscarnet is………. .
(A) Kidney damage
(B) Liver damage
(C) Neurotoxicity
(D) Hypotension
26. Which of the following is tissue schizontocide?
(A) Chloroquine
(B) Mefloquine
(C) Proguanil
(D) Primaquine
27. ………… is a cell cycle specific anticancer agent.
(A) L-asparaginase
(B) Actinomycin-D
(C) 5-Flurouracil
(D) Vincristin
28. …………. of tablet is the only dimensional variable determined by process variable.
(A) Diameter
(B) Thickness
(C) Weight
(D) All of these
29. Acceptable limits of friability for conventional tablet is ………. of their weight.
(A) Less than 1.5%
(B) Less than 0.5%
(C) Less than 0.5-1.0%
(D) Less than 2.0%
30. Stability of suspensions can be increased by ………… .
(A) reducing interfacial tension
(B) decreasing total surface area
(C) increasing viscosity of medium
(D) All of the above
31. Whiskering phenomenon is related to……. .
(A) Suspensions
(B) Creams
(C) Tablets
(D) Capsules
32. DOT means ………… .
(A) Department of Telecommunication
(B) Department of Transportation
(C) Department of Technology
(D) all of the above
33. Pycnometer is used to measure……….. .
(A) Specific gravity
(B) Sedimentation
(C) Density
(D) Particle size
34. Largest size of capsule is…………. .
(A) 0
(B) 00
(C) 1
(D) 5
35. Credit of formulating Phase rule goes to ….. .
(A) Einstein
(B) Gibbs
(C) Stokes
(D) Raoults
36. HEPA filter prevents the entry of microbes of size ………. .
(A) Less than 0.3μ
(B) Less than 0.1μ
(C) More than 0.3μ
(D) More than 0.1μ
37. According to USP, the test used to confirm the actual presence of the compound is:
(A) Standard of Purity
(B) Standard of Identity
(C) Standard of Quality
(D) Standard of Potency
38. Moisture penetration in to the tablet core is prevented by ……….. .
(A) Sub coating
(B) Seal coating
(C) Syrup coating
(D) Polishing
39. The system consisting of loosely packed particles that can be redispersed easily is called as:
(A) Flocculated system
(B) Coagulated system
(C) Deflocculated system
(D) Aggregated system
40. In Aerosol filling process, hydrocarbon as a propellant is not be used in the following apparatus.
(A) Pressure filling apparatus
(B) Cold filling apparatus
(C) Compressed filling apparatus
(D) All the above
41. Class 10,000 is one in which the particle count is not more than …………. .
(A) 10,000 per cubic foot
(B) 10,000 per cubic metre
(C) 10,000 per cubic inch
(D) 10,000 per cubic centimeter
42. As per USP XX, in content uniformity test, how many capsules are used?
(A) 20
(B) 30
(C) 40
(D) 50
43. Which of the following is permeation enhancer?
(A) Dimethylsulfoxide
(B) Lecithin
(C) Benzalkonium chloride
(D) Paraffin wax
44. Abrasive used in Dental preparation:
(A) Diacalcium phosphate
(B) SLS
(C) Selenium sulphate
(D) Colloidal silicate
45. The temperature at which the given mixture of air & water vapor must be cool to become saturated is:
(A) Yield point
(B) Craft point
(C) Dew point
(D) Bubble point
46. Acid solubility limits for empty capsule shell is ……….. .
(A) Dissolved in < 5 min. in 0.5% aqueous HCl
(B) Dissolve in < 5 min. in 0.1% aqueous HCl
(C) Dissolve in < 15 min, in 0.5% aqueous HCl
(D) Dissolve in < 5 min. in 0.5% aqueous HCl
47. Local anesthetic used in parenteral formulation is ……….. .
(A) Ethyl alcohol
(B) Benzyl alcohol
(C) Methyl alcohol
(D) Ethylene glycol
48. All of the following are oil soluble antioxidants except ……….. .
(A) Propyl gallate
(B) a-tocopherol
(C) BHT
(D) Ascorbic acid
49. Asymmetric molecule frequently exhibits a fourth phase, called mesophase which lies between ……….. .
(A) Liquid & gas phase
(B) Liquid & Crystalline phase
(C) Crystalline & Gas phase
(D) All
50. The moisture condensed on the surface of glass container that can extract some weakly bound alkali leaving white deposit of alkali carbonate is called ………… .
(A) Flaking
(B) Coring
(C) Leaching
(D) Weathering
51. The protein part of enzyme is referred as ……….. .
(A) haloenzyme
(B) apoenzyme
(C) prosthetic group
(D) activator
52. Which functional group is transferred by coenzyme biocytin?
(A) acyl
(B) CO2
(C) H-atom
(D) None of these
53. Some enzymes act on closely related substrate. This phenomenon is known as :
(A) absolute substrate specificity
(B) relative substrate specificity
(C) broad specificity
(D) none
54. Cofactor required for DNA polymerase is ……….. .
(A) Zn++
(B) Cu++
(C) Ni++
(D) Fe++
55. For production of enzyme, fermentation method used is ……….. .
(A) submerged culture
(B) deed bed culture
(C) surface culture
(D) All of these
56. PCR stands for ……….. .
(A) Polymerase chain reaction
(B) People choice reaction
(C) Both (A) & (B)
(D) None
57. In hepatic jaundice, Level of ……….. type of serum bilirubine is increased.
(A) Unconjugated
(B) Conjugated
(C) Both (A) & (B)
(D) None of the above
58. One of the following substances is administered intravenously to measure glomerular filtration rate:
(A) Inulin
(B) Creatinine
(C) urea
(D) Mannitol
59. The simultaneous transport of two different species in the same direction is termed as :
(A) Cotransport system
(B) Uniport system
(C) Antiport system
(D) Symport system
60. Basal metabolic rate is measured in :
(A) cal/m2/hr
(B) cal/kg/hr
(C) cal/hr
(D) cal/kg
61. The population or number of living micro-organisms per defined unit surface or system is called as :
(A) Z-value
(B) F-value
(C) Bioburden
(D) Resistance value
62. Discrete sequence of DNA code for given biological molecule such as structural proteins & enzyme is:
(A) Chromosome
(B) Gene
(C) Histone
(D) None
63. Conversion of DNA information sequence is to mRNA sequence :
(A) Transduction
(B) Transcription
(C) Transformation
(D) Translation
64. Restriction Endonuclease mostly used in gene manipulation is of:
(A) Type I
(B) Type II
(C) Type III
(D) All of these
65. One of the following is killed vaccine:
(A) Small pox vaccine
(B) BCG
(C) Sabine poliomyelitis
(D) Salk poliomyelitis
66. The time in minute at specific temperature needed to kill a population of cell or spore is called:
(A) D-value
(B) F-value
(C) Z-value
(D) None of the above
67. Maltose on hydrolysis yields:
(A) 2 glucose units
(B) Glucose + Fructose
(C) Glucose + Galactose
(D) 2 units of galactose
68. Plasmids having multiple copies per cell is called as:
(A) Cryptic plasmids
(B) Relaxed plasmid
(C) Stringent plasmid
(D) Conjugative plasmid
69. D-Glucose on reduction gives:
(A) D-Dulcitol
(B) D-Mannitol
(C) D-Sorbitol
(D) None of these
70. Wernicke Korsakoffs syndrome is occur due to the deficiency of :
(A) Vit-B1
(B) Vit-B2
(C) Vit-B6
(D) Vit-B7
71. Annealing of primer in PCR is performed at temperature:
(A) 95°C
(B) 74°C
(C) 54°C
(D) 20°C
72. The phenomenon in which one or more base pair are inserted or delated from DNA is called :
(A) Point mutation
(B) frame shift mutation
(C) Silent mutation
(D) Missense mutation
73. X-rays are used for determination of structure of protein because :
(A) X-rays can penetrate the protein
(B) X-rays is higher energetic region in electromagnetic spectrum
(C) Wavelength of X-rays & molecular dimension of protein are of same order
(D) All of the above
74. ESR of compound is performed in ………. region.
(A) Radiowaves
(B) Microwaves
(C) γ-rays
(D) Cosmic rays
75. 1 Joule is equal to ………….. .
(A) 10−7 erg
(B) 107 erg
(C) 10−8 erg
(D) 107 erg
76. The time in second required for the passage of successive maxima or minima through a fixed point in space is called :
(A) Period
(B) Wavelength
(C) Frequency
(D) Amplitude
77. Which of the following is not included under physical evaluation of the plants?
(A) microbiological limits
(B) volatile oil content
(C) refractive index
(D) acid value
78. The biological source of Guar gum is:
(A) cyamposis tetragonolobous
(B) acacia arabica
(C) astragalus gummifer
(D) All of these
79. Granulated honey contains:
(A) crystalline glucose
(B) crystalline dextrose
(C) crystalline sucrose
(D) crystalline fructose
80. Cascara bark contains :
(A) O-glycoside
(B) C-glycoside
(C) Both (A) & (B)
(D) None of these
81. Aglycon part present in lanatoside B is :
(A) Digitoxigenin
(B) Gitoxigenin
(C) Digoxigenin
(D) Diosgenin
82. Antigastric effect of liquorice is due to the presence of:
(A) saponin
(B) flavonoides
(C) coumarin
(D) None of these
83. Sodium picrate test is used for identification of:
(A) gallic acid
(B) chebulic acid
(C) ellagic acid
(D) catechutannic acid
84. Olive oil is obtained from………… of Olea europoem.
(A) leaves
(B) fruits
(C) seeds
(D) all of these
85. Chief constituent of Cuminum cyminium is :
(A) carvone
(B) limonene
(C) cuminic aldehyde
(D) all of these
86. One of the following is not characteristic of mother clove:
(A) dark brown colour
(B) starch grain present
(C) starch grain absent
(D) inferior in volatile content
87. Which of the following is not a true alkaloid?
(A) pilocarpine
(B) quinine
(C) atropine
(D) ephedrine
88. Vinca leaves contain ……… stomata.
(A) Cruciferous
(B) anomocytic
(C) anisocytic
(D) actinocytic
89. All of the following are water insoluble alkaloids except:
(A) ergometrine
(B) ergotamine
(C) ergocristine
(D) ergocornine
90. Diactetyl derivative of morphine is called :
(A) codeine
(B) heroin
(C) Both (A) & (B)
(D) None of these
91. Glandular trichomes present in belladonna leaf are:
(A) uniseriate unicellular
(B) uniseriate multicellular
(C) biseriate unicellular
(D) biseriate unicellular
92. Quinine & quinidine are :
(A) stereoisomers
(B) enantiomers
(C) epimers
(D) None of these
93. All of the following contains oleoresins except:
(A) Canada balsam
(B) capsicum
(C) jalap
(D) copaiba
94. Marine drug having cardiovascular activity is:
(A) laminine
(B) eunicine
(C) ara-c
(D) All of these
95. Heckel plot is related to:
(A) deformation
(B) mixing
(C) granulation
(D) None of these
96. Liquid glucose used as binder is a solution of………..sugar in water.
(A) 20%
(B) 50%
(C) 80%
(D) 90%
97. In NMR, the component of electromagnetic radiation responsible for absorption of radio-frequency waves is:
(A) magnetic
(B) electric
(C) Both (A) & (B)
(D) None of these
98. The process in which emitted radiation is identical in frequency to the radiation employed for excitation is called:
(A) nonresonance fluroscence
(B) resonance fluroscence
(C) nonradiative relaxation
(D) None
99. Fabry-perot filters are related to:
(A) interference filter
(B) absorption filter
(C) prism
(D) monochromator
100. The material used in pyroelectric detector is:
(A) platinum
(B) silicon carbide
(C) triglycine sulphate
(D) thorium rod
101. The wavelength of radiation emitted or absorbed by a rapidly moving atoms decreases the motion towards the transducer & if the atom is receding from the transducer. The Phenomenon is called as:
(A) Stoke shift
(B) Doppler effect
(C) Blue shift
(D) Red shift
102. Cold vapor atomization method in AAS is used only for the determination of:
(A) Hg
(B) Na
(C) Mg
(D) Ca
103. Zeeman effect is related to:
(A) NMR
(B) IR
(C) X-ray
(D) AAS
104. Detector used in the mass spectrometry:
(A) Faraday cup
(B) electron multiplier
(C) photographic plate
(D) All of these
105. Which one of the following is not an auxochrome?
(A) ―OH
(B) ―NH2
(C) ―NO2
(D) C6H6
106. Which is false about fluorescence?
(A) It involve a change in electron spin
(B) It is spontaneous phenomenon
(C) It occurs in singlet state of atom
(D) None of the above
107. C-N stretching in amine is observed in the range of:
(A) 2100-2260 cm−1
(B) 1610-1680 cm−1
(C) 1180-1360 cm−1
(D) 3590-3650 cm−1
108. “Protons present on alkene show deshielded spectra & protons present on alkyne show shielded spectra”. This is due to :
(A) van der Walls deshielding
(B) anisotropic effect
(C) nuclear overhouser effect
(D) None
109. In HPLC, detector used for compounds containing thiols or sulphide compounds is;
(A) refractive index
(B) electrochemical
(C) light scattering
(D) mass spectroscopy
110. Hydrolysed silica for stationary phase in bonded phase chromatography is prepared by the hydrolysis of silica with :
(A) 0.1 M HCl
(B) 0.1 M H2SO4
(C) 1M HCl
(D) 1M H2SO4
111. Particle size in case of HPTLC is near about:
(A) 20 μ
(B) 15 μ
(C) 10 μ
(D) 5 μ
112. Which of the following is used as primary standard?
(A) NaOH
(B) KHP
(C) HCl
(D) H2SO4
113. The temperature above which distinct liquid phase of substance cannot exist regardless of pressure is called:
(A) critical temperature
(B) ambient temperature
(C) transition temperature
(D) None of these
114. One of the following technique is used for the separation of amphiproteic species such as amino acid is:
(A) capillary gel electrophoresis
(B) capillary isotachophoresis
(C) capillary isoelectric focusing
(D) capillary zone electrophoresis
115. The thermal technique in which difference in heat flow into a substance and a reference are measured as function of sample temperature while the two are subjected to controlled temperature program is:
(A) DSC
(B) TGA
(C) DTA
(D) All of these
116. The solution containing 1 mole of substance per 1000 gm of solvent is called:
(A) molarity
(B) formality
(C) molality
(D) normality
117. According to …………. theory, acid is any substance that ionizes in water to give H+.
(A) Arrhenius
(B) Lewis
(C) Lowry-Bronsted
(D) None of these
118. The graph obtained in case of polarography is:
(A) current v/s potential
(B) current v/s volume
(C) current v/s time
(D) potential v/s volume
119. Retention factor of solute for better separation is in the range of:
(A) 2-10
(B) 10-20
(C) 20-30
(D) 30-40
120. Tendom mass spectroscopy is :
(A) MS-MS
(B) MS-ICP
(C) SIMS
(D) GC-MS
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