Pharmaceutical Science (PY) Competitive Examination-2014
(GPAT, CET, NIPER etc.)
1. Enteric coated tablet:
(A) Protect drug from acidic environment
(B) Prevent gastric irritation
(C) delays absorption
(D) All the above
2. Which of the following is true?
(A) Low pKa, stronger the acid
(B) Low pKa, stronger the base
(C) High pKa, weaker the acid
(D) High pKa, stronger the acid
3. Directly compressible diluents is:
(A) Microcrystalline cellulose
(B) Lactose
(C) Starch
(D) Methyl cellulose
4. Wursters process means:
(A) Coacervation-phase separation
(B) Pan coating
(C) Air supension
(D) Solvent evaporation
5. Bloom strength of gelatin is normally:
(A) 50 gm
(B) 200 gm
(C) 300 gm
(D) 400 gm
6. Particle size determination of Aerosol is performed by:
(A) Cascade impactor
(B) Gas chromatography
(C) Andersons pipette
(D) Pcynometer
7. Which of the following surfactant is amphoteric in nature?
(A) Benzalkonium chloride
(B) Lecithin
(C) Polyalkoxy ether
(D) SLS
8. The humidity in the operating area of capsule manufacturing is normally:
(A) 60%
(B) 50%
(C) 40%
(D) 20%
9. Millard reaction occurs between :
(A) Hydrous lactose & amine
(B) Unhydrous lactose & amine
(C) Starch & amine
(D) All the above
10. The phenomenon of increasing the solubility of various substance in water due to presence of large amount of additives is called:
(A) Solubilization
(B) Hydrotrophy
(C) Cosolvency
(D) Complexation
11. Complete separation of tablet in to two or more layers is called as:
(A) Capping
(B) Lamination
(C) Picking
(D) Mottling
12. The electrode used in polarography is:
(A) Dropping mercury
(B) Static mercury
(C) Both (A) & (B)
(D) None of these
13. Spans are ……….. .
(A) Polyoxythylene ether of fatty acid ester
(B) Sorbitol ester of fatty acid
(C) Combination of Polyoxyethylene & polyoxypropylene
(D) High mole. wt. polyethylene glycol
14. Dilatometric curve is a plot of:
(A) Weight v/s temperature
(B) Specific volume v/s temperature
(C) Volume v/s temperature
(D) Density v/s temperature
15. A relation between vapour pressure & Absolute temperature of liquid is given by
(A) Gibbs equation
(B) Clausius-Clapeyron equation
(C) Arrhenius equation
(D) Vant Hoff equation
16. 1 Tera is equal to ……….. .
(A) 109
(B) 1012
(C) 1015
(D) 1018
17. The temperature at which liquid passes into solid state is known as:
(A) Melting point
(B) Triple point
(C) Dew point
(D) Freezing point
18. The movement of liquid through a plug or membrane across which potential is applied is called:
(A) Electrophoresis
(B) Electrodiffusion
(C) Electroosmosis
(D) All of these
19. Material used in IUDs is:
(A) Copper
(B) Cobalt
(C) Aluminium
(D) Titanum
20. Reynold number is related to:
(A) Sedimentation
(B) Flow of fluid
(C) Evaporation
(D) Filtration
21. As per USP, Type II glass means:
(A) Borosilicate
(B) Treated soda lime
(C) Soda lime
(D) General purpose Soda lime
22. The vesicle of lipid bilayer enclosing an aqueous compartment is termed as:
(A) Neosome
(B) Aquasome
(C) Liposome
(D) Mesosome
23. Drop weight method is used to measure:
(A) Viscosity
(B) Specific volume
(C) Surface tension
(D) Solubility
24. The energy required for size reduction is directly proportional to the product diameter is given by :
(A) Kick law
(B) Raults law
(C) Bond law
(D) Rittinger law
25. In sterile dosage form, all of the following buffers are used except:
(A) Acetate
(B) Citrate
(C) Borate
(D) Phosphate
26. LAL test is for:
(A) Bacteria
(B) Pyrogen
(C) Fungi
(D) Yeast
27. Raults law is related to:
(A) Osmotic pressure
(B) Vapour pressure
(C) Atmospheric pressure
(D) All the above
28. All of the following microorganisms present in the eye except:
(A) S. epidermis
(B) S. aureus
(C) Diphtheroids
(D) E.coli
29. A Browns tube used as indicator in ………sterilization.
(A) Dry heat
(B) Moist heat
(C) Radiation
(D) Chemical
30. Measles vaccine is given after ……….. month of birth:
(A) 3
(B) 6
(C) 9
(D) 12
31. ………. is synthetic benzimidazole derivative anthelmintic.
(A) Albendazole
(B) Ketokonazole
(C) Fluconazole
(D) All of these
32. ………….. is a depolarizing neuromuscular blocking agent that causes spastic paralysis of the helminth:
(A) Mebendazole
(B) Niclosamide
(C) Piperazine
(D) Pyrental
33. Zidovudine is a ………….. analogue.
(A) Pyrimidine
(B) Thymidine
(C) Cytosine
(D) Guanine
34. The life time of an excited singlet state is near about:
(A) 10−12
(B) 10−6
(C) 10−4
(D) 10−20
35. All adrenocorticosteroids are derived from:
(A) Pregnane
(B) Estrane
(C) Cytosine
(D) Histamine
36. The source used in spectroflurometer is:
(A) Xenon flash lamp
(B) Xenon arc lamp
(C) Mercury vapour lamp
(D) All the above
37. Precursor of Insulin called proinsulin contain…….amino acid:
(A) 68
(B) 86
(C) 79
(D) 97
38. All of the following hormonal drug possess a steroidal nucleus except:
(A) Ethinyl estradiol
(B) Levothyronine
(C) Prednesolone
(D) Norethindrone
39. Detection of Iron content in blood is done by:
(A) Flame emission spectroscopy
(B) Atomic absorption spectroscopy
(C) Both A & B
(D) None of the above
40. The energy level affected in UV-spectroscopy is:
(A) Electronic
(B) Vibrational
(C) Rotational
(D) All of these
41. In the IR spectrum of organic compound, the hydrogen stretching region is usually first investigated to determine:
(A) Aromaticity
(B) Aliphatically
(C) Both A & B
(D) Functional group
42. Cis 1, 2-dimethyl Cyclohexane has ……… confirmation.
(A) e, e
(B) e, a
(C) Both (A) & (B)
(D) None of these
43. 
This is cis 2,3-diphenylbutene on reaction catalytic hydrogenation over palladium in acetic acid, it yields predominantly………..2, 3-diphenylbutene.
(A) meso
(B) d
(C) l
(D) dl
44. The source of radiation used in far IR region is :
(A) Tungsten filament
(B) High pressure mercury lamp
(C) Globar source
(D) Nerst glower
45. Find the correct statement about Raman spectroscopy:
(A) It can be used to detect the molecule with IR inactive spectra
(B) It can not be used to study the material in aqueous solution
(C) Raman scattering power is inversely proportional to concentration
(D) All the above
46. mλ = 2d sin θ This equation is related to:
(A) X-ray diffraction
(B) ESR
(C) Raman spectroscopy
(D) None of the above
47. 
In above structure H2/H4 are:
(A) Chemically equivalent
(B) Magnetic equivalent
(C) Both (A) & (B)
(D) None of the above
48. 1 torr is equal to ………. .
(A) 1333 pascal
(B) 133.3 pascal
(C) 13.33 pascal
(D) 1.333 pascal
49. In reverse phase chromatography, stationary & mobile phase are …………. respectively.
(A) Polar & Non polar
(B) Non polar & Polar
(C) Polar & Polar
(D) Non polar & Non polar
50. In mass spectroscopy, ionization source for the biological compound like harmone, enzyme is:
(A) Chemical
(B) Electron impact
(C) FAB
(D) All of these
51. Solvent programming in HPLC is called as:
(A) Isocratic elution
(B) Gradient elution
(C) Both (A) & (B)
(D) None of these
52. Pulse free pumps used in HPLC is:
(A) Syrringe type pump
(B) Pneumatic pump
(C) Both (A) & (B)
(D) None of the above
53. Peptidomimetics are molecules with …………. .
(A) No peptide bonds
(B) Molecular weight less than 700
(C) Activity similar to apeptide
(D) All the above
54. ………… can be used to catalysed organic reaction with regioselectivity:
(A) Cyclodextrine
(B) AlLiH4
(C) Both (A) & (B)
(D) None of these
55. Invert sugar is a mixture of D(+)-glucose and D(-)-fructose. This sugar is:
(A) Dextrorotatory
(B) Levorotatory
(C) optically inactive
(D) racemic modidication
56. The dextro form of β-methacholine is approximately 500 times more active than the levo enantiomer. The observed difference is most likely due to difference in:
(A) Dissolution
(B) solubility
(C) distribution
(D) receptor selectivity
57. Levulose is:
(A) D(+)-glucose
(B) D(-)-fructose
(C) D(-)-glucose
(D) D(+)-fructose
58. One of the following is soluble in the alcohol:
(A) Asafoetida
(B) Acasia
(C) Gelatin
(D) Aloe
59. One of the following is soluble in the alcohol:
(A) Asafoetida
(B) Acaisa
(C) Gelatin
(D) Aloe
60. Frothing on shaking of a powder with water indicates presence of:
(A) Tannin
(B) Saponine
(C) Carbohydrate
(D) None
61. Colour of Ergot is:
(A) White
(B) Dark-brown
(C) Yellow
(D) Green
62. …………. colour is observed in Murexide test for………..
(A) Yellow, Indole
(B) Blue, Imidazole
(C) Purple, Purine
(D) Green, Pyrrole
63. Shinoda test is used for:
(A) Tannin
(B) Protein
(C) Flavonoid
(D) Fat
64. Bioactive product presented as dietary supplements are called:
(A) Drugs
(B) Neutraceuticals
(C) Cosmaceuticals
(D) None of these
65. Famous insecticide BHC means:
(A) Benzene hexachloride
(B) Benzene heptachloride
(C) Benzene hexaiodide
(D) Benzene heptaiodide
66. Gibberellin A was isolated in 1938; which is actually a mixture of atleast six gibberellins. One of them is GA3; which is termed as:
(A) Gibberellic acid
(B) Gibberellin
(C) Gibbane
(D) None of these
67. Watson & ………. announced discovery of DNA structure in………… .
(A) Sanger, 1960
(B) Crick, 1953
(C) Crick, 1960
(D) Sanger, 1953
68. Shikimic acid acts as precursor for biosynthesis of:
(A) Glycosides
(B) Steroids
(C) Amino acid
(D) None of these
69. One of the following is correct:
(A) Stomata & water pore are same
(B) Stomata are immovable
(C) Water pore are immovable
(D) Water pore are movable
70. Ash content represent:
(A) Organic content
(B) Inorganic content
(C) Both (A) & (B)
(D) Water content
71. Strong acrid smell of mustered oil is due to:
(A) Allyl isothiocyanate
(B) Sinigrin
(C) Myrocin
(D) Myristic acid
72. Bandha soap is related to:
(A) Myristica fragrans
(B) Acorus calamus
(C) Eugenia caryophyllus
(D) Hedychium spicatum
73. Bloom strength is related to:
(A) Lectin
(B) Gelatin
(C) Heparin
(D) Trypsin
74. High production of Crocus sativum in India:
(A) Tamil Nadu
(B) Maharashtra
(C) Kashmir
(D) Assam
75. Deadly Night Shade leaf is synonym of:
(A) Belladona
(B) Hyoscine
(C) Atropine
(D) Datura
76. Opium alkaloids are present as salt of:
(A) Acetic acid
(B) Meconic acid
(C) Phenoxacetic acid
(D) Benzoic acid
77. Idioblast of calcium oxalate crystals is a characteristic of:
(A) Ipecacuanha root
(B) Aconite root
(C) Kurchi bark
(D) Cinchona bark
78. Glyoxaline nuclease is a part of structure of:
(A) Lobeline
(B) Ephedrine
(C) Pilocarpine
(D) Morphine
79. Phloem fibres are absent in:
(A) Cinchona bark
(B) Liquorice root
(C) Kurchi bark
(D) All of these
80. Curcuma longa rhizomes are yellow due to:
(A) Curcuminoids
(B) Camphene
(C) Starch grain
(D) All of these
81. One of the following is not mineral drug:
(A) Calamine
(B) Guggul
(C) Kieselghur
(D) Shilajit
82. Unlighnified pith is a microscopic characteristics of:
(A) E. sinica
(B) E.equisetia
(C) E.distachya
(D) All of these
83. One pair is incorrect:
(A) Anisocytic-Cruciferous stomata
(B) Paracytic-Rubiaceous
(C) Anomopcytic-Ranunculaceaous
(D) Dicytic-Irreguler cell stomata
84. One of the following is growth inhibitor harmone in plants:
(A) Auxins
(B) Ethylene
(C) Phosphon
(D) Cytokinins
85. Choromome are equally divided to two opposite poles in:
(A) Metaphase
(B) Prophase
(C) Telophase
(D) Anaphase
86. Reticulate parenchyma is absent in:
(A) Caraway fruit
(B) Dill fruit
(C) Fennel fruit
(D) All of these
87. Glucose has ………. isomers.
(A) 16
(B) 12
(C) 32
(D) 24
88. Presence of ………….. in a molecule precludes chirality.
(A) Plane of symmetry
(B) Point of symmetry
(C) Both (A) & (B)
(D) None of the above
89. Dimethyl ether & ethanol are …………. isomers.
(A) conformational
(B) configurational
(C) constitutional
(D) stereo
90. Zeigler Natta catalyst consist of:
(A) Metal halide
(B) Aluminium alkyl
(C) Both (A) & (B)
(D) None of these
91. ………. enanntiomer of Ibuprofen is actie.
(A) S(+)
(B) S(-)
(C) R(+)
(D) R(-)
92. One of the following is false:
(A) Configurations D & dextro are different.
(B) Sinister means anticlockwise.
(C) L-compound always rotates plane of plane polarized light to left.
(D) All the above
93. Following molecules has …………… stereocentres.
(A) 1
(B) 2
(C) 5
(D) no
94. (a + (b)2 = ………….. .
(A) a2 + 2ab + b2
(B) a2 + a2b2 + b2
(C) (a + b) (a – b)
(D) a2 + 2ab + b2
95. A diene CH2 = C(CH3)CH = CH2 is:
(A) Isoprene
(B) terpenes
(C) citronellol
(D) None of these
96. The specific rotation for a pure enantiomer is known to be −39° g−1 mL−1 dm−1. A sample containing both enantiomers is found to have an observed rotation of −62° in a one dm tube at a concentration of 3.5 g/100 mL. What is the optical purity of the sample?
(A) 73% of the (−) enantiomer and 97% of the (+) enantiomer.
(B) 3% of the (−) enantiomer and 97% of the (+) enantiomer.
(C) 27% of the (−) enantiomer and 73% of the (+) enantiomer
(D) 97% of the (−) enantiomer and 3% of the (+) enantiomer
97. Epoxides are compounds containing ………. membered ring.
(A) two
(B) three
(C) four
(D) five
98. Number of atoms (Population) in ground and excited state are expressed by:
(A) Maxwell-Boltzmann equation
(B) Planks constant
(C) Beers law
(D) None of the above
99. MSDS means :
(A) Material Safety Data Sheet
(B) Material Standard Data sheet
(C) Manual of Standard Drug Substance
(D) None of the above
100. ODS in HPLC means:
(A) Octadecyl Silane
(B) Organic Drug Solution
(C) Octadecyl Silance
(D) None of the above
101. Isoelectric point of amino acids is a:
(A) Temperature
(B) pH
(C) Pressure
(D) Volume
102. Poisoning capacity is related to :
(A) Conductimetry
(B) pH metry
(C) Potentiometry
(D) Voltametry
103. Nitrogen in proteins can be determined by :
(A) Kjeldahl analysis
(B) Nernst equation
(C) Michaelis equation
(D) None of these
104. Amino acids are:
(A) Acidic
(B) Basic
(C) Amphoteric
(D) All of these
105. pH transition range of phenolphthalein is:
(A) pH 8-10
(B) pH 3-5
(C) pH 11-13
(D) pH 6-8
106. What man filter paper 42 has pore size of:
(A) 8 μm
(B) 2.5 μm
(C) 20 μm
(D) 25 μm
107. Accidental error are also called as:
(A) Indeterminant error
(B) Random error
(C) Both (A) & (B)
(D) None of the above
108. …………. column in GC shows the best efficiency.
(A) WCOT
(B) SCOT
(C) FSOT
(D) Packed
109. Glass transition temperature is related to:
(A) Carbohydrates
(B) Polymer
(C) Lipid
(D) None of these
110. X-rays are:
(A) α-particle
(B) β-particle
(C) Electromagnetic radiation
(D) γ-particle
111. Curie point of triglycin sulphate is:
(A) 47°C
(B) 74°C
(C) 38°C
(D) 83°C
112. Shim coils are used in:
(A) Mass spectrometer
(B) NMR spectrometer
(C) IR spectrometer
(D) UV spectrometer
113. Enantiotopic group are attached to :
(A) Prochiral center
(B) achiral center
(C) Both (A) & (B)
(D) None of these
114. Homotopic ligands are :
(A) Enantiotopic
(B) Distereotopic
(C) Both (A) & (B)
(D) None of these
115. Starch gives blue colour on reaction with iodine. This is due to:
(A) Amylase
(B) Amylopectin
(C) Both (A) & (B)
(D) None of these
116. Prosthetic group of hemoglobin contain iron bound to:
(A) Pyridine rings
(B) Pyrrole rings
(C) Pyrimidine rings
(D) Tyrosine rings
117. ……….. is used in sangers method of terminal residue analysis.
(A) Phenyl isothiocynate
(B) Corboxypeptidase
(C) Ethyl chloroacetate
(D) 2, 4-dinitroflurobenzene
118. …………… received 2 Nobel prizes:
(A) Sanger
(B) Watson
(C) Both (A) & (B)
(D) None of these
119. If INDIA is written as 95491, DELHI will be written as:
(A) 45389
(B) 45489
(C) 45498
(D) 45398
120. A goes 4 km to south then 8 km west then 6 km north then 8 km east and then 2 km south. How far is A from the starting point?
(A) 2 km
(B) 1 km
(C) 0 km
(D) 3 km
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