LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PHYSICS, COMPUTER SCI. & APPL.

THIRD SEMESTER – APRIL 2012

PB 3208/3202 – BIOINFORMATICS – I

Date : 02-05-2012              Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

PART- A

Answer all the questions:                                                                                            (20 marks)

I Choose the correct answer :                                                                                    (5×1=5 marks)

1. Where is ribosome located in plant and animal cell?
2. a) inside the nucleus b) on the endoplasmic reticulum
3. c) near the cell membrane d) inside the vacuole

2. The database that classifies protein according to their structure and function is _______________.
3. a) PIR-PSD b) i Proclass                 c) ALN                                    d) RESID

3. The one that collects and processes sequence data for PIR-international is ________________.
4. a) MIPS b) PATS                      c) SMD                                   d) DIP

4. Cells were first discovered by _____________.
5. a) Robert hooke b) George kohler         c) Edward jenner        d) Pasteur

5. Identify the protein structure analysis database.
6. a) RCSB-PDB b) RasMol                   c) ProtParam               d) Web-Thermodyn

II State whether the following statements are True or False:                               (5×1=5 marks)

6. ProtParam computes various physico-chemical properties of proteins.
7. UAA is a start codon.
8. 3ˊ- 5ˊstrand is called a non-coding strand.
9. RasMol is licensed dually.
10. Smith-Watermann algorithm is used to align multiple sequences.

III Complete the following:                                                                                      (5×1=5 marks)

11. JSTOR stands for ________________.
12. PDB is generated by ______________.
13. Secondary structure of DNA was proposed by _________________.
14. RasMol is otherwise called as ___________.
15. Low helical stability region is predicted by _______________.

IV Answer the following each in about 50 words:                                                 (5×1=5 marks)

16. What are restriction enzymes?
17. Define protein synthesis.
18. Name the 3 institutes that contribute towards International Nucleotide Sequence database

collaboration?

19. Illustrate the central dogma of molecular biology.
20. Write the applications of HGP.

PART – B

Answer the following, each answer within 500 words; Draw diagram wherever necessary:                                                                                                                                                         (5 × 8 = 40 marks)

21. a) Give an account on the cytoplasmic organelles of eukaryotic cell.

OR

1. b) Briefly explain transcription process.
2. a) Write notes on i) EMBL ii) DDBJ

OR

1. b) Give details of the currently used human genome project.
2. a) Write short notes on i) disease database                  ii) journal database

OR

1. b) Explain the steps involved in Needleman and Wunsch algorithm.
2. a) Describe Chou- Fasman method.

OR

1. b) Give an account on different types of BLAST program.
2. a) Explain the software used for visualizing the 3D structure of proteins.

OR

1. b) Elucidate the software used for predicting the physical properties of nucleic acids.

PART – C

 Answer any TWO of the following, each answer within 1500 words; Draw diagram wherever necessary:                                                                  (2 × 20 = 40 marks)

26. Draw a Smith-Watermann algorithm for the following using the values of match: 1, mismatch:

0, gap: -1

ADCNGRQCLCRPM

AGCGNRCKCRP

27. Describe the structure and functions of DNA.
28. Write notes on i) PIR ii) Swissprot
29. Explain secondary structure prediction on proteins.

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