LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

BV 03

FIRST SEMESTER – April 2009

ML 1809 – MOLECULAR BIOLOGY

 

 

 

Date & Time: 28/04/2009 / 1:00 – 4:00  Dept. No.                                                   Max. : 100 Marks

 

 

 

SECTION –A

Answer ALL the following.                                                                     10 x 2 =20 marks

1. Draw the structure of nucleus and add a note on it.
2. Expand a) FDA b) CLIA  c) ASCLD  d) CDC.
3. What is the difference between prader – willi syndrome and angelman syndrome?
4. List the different classes of Oncogene.
5. Mention the role played by CFTR in human body.
6. Write the difference between rho-dependent and rho-independent terminators.
7. Write the original wobble predictions.
8. Define mutagen.
9. Mention the role played by DNA unwinding proteins
10. What are types of euploidy?

SECTION B

Answer any FOUR of the following.                                                    4 x 10=40 marks

11. Explain the structure and function of RNA.
12. Describe cystic fibrosis in detail.
13. Explain the forensic identity testing by DNA analysis.
14. Describe the four rules that govern the synthesis of bio-polymers with illustrations.
15. Give an account on Sickle cell anaemia.
16. Describe the three common DNA excision repair mechanisms in our body.

 

SECTION-C

Answer any TWO of the following.                                                      2 x 20=40 marks

17. Explain the mechanism of translation.
18. Describe the translocation of mutations in various types of cancer
19. Draw the structure of eukaryotic cell and explain a) Golgi bodies b) Mitochondria

c)Lysosomes

20. Explain the morphology and functional elements of eukaryotic chromosomes

 

 

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