LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.
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FIFTH SEMESTER – November 2008
PB 5407/PB 5404 – BIOINFORMATICS
Date : 14-11-08 Dept. No. Max. : 100 Marks
Time : 9:00 – 12:00
PART – A (20 marks)
Answer ALL questions.
I Choose the correct answer (5×1= 5 marks)
- Software used for drug designing
- INSIGHTII b) GENSCAN c) GLIMMER d) GRAIL
- Software used for gene expression analysis
- GENOVIZ b) GENSCAN c) GLIMMER d) GRAIL
- Database for structural classicification of proteins
- SCOP b) CATH c) SGD d) PROSITE
- Tool used for homology modelling
- a) MODELLER b) PIPMAKER c) AUTODOCK d) INSIGHTII
- Tool used for pathway analysis
- KEGG b) MODELLER c) AUTODOCK d) INSIGHTII
II State whether the following true or false : (5×1= 5 marks)
- ________ is termed as non coding region.
- ________ is a tool for the gene prediction in microbial genomes.
- The size of the Homa sapien genome is _________.
- Clustalw developed by ___________.
- ________ is a database for domains & protein families.
II Complete the following: (5×1=5 marks)
- —————- is a Restriction Site tool.
- ———— is Splice Site Prediction tool
- Rasmol is—————-.
- ————– is multiple sequence alignment tool.
- DDBJ is maintained by——————-.
IV Write notes on the following, each not exceeding 50 words. (5×1=5 marks)
- Write notes on Restriction site
- Define Swiss-model
- Difference between Local & Global alignment
- Comment on BLAST
- Define INTERNET.
PART – B
Answer any FIVE of the following, each not exceeding 350 words (8×5= 40 marks)
Draw diagrams / flow charts wherever necessary.
- Explain the Post Translational Modifications of proteins with a appropriate example.
- Explain the principles, types of
- What are the levels of protein structure & explain them briefly with a appropriate diagram
- Write notes on a) Paralogs b) Orthologs d) Steps involved in Phylogenetic Analysis.
- Explain briefly about S-W algorithm & add on differences between N-W & S-W algorithm
- Explain any two important online journal databases briefly.
- Write briefly about Genomic databases
- Give short notes on
- a) Splicing and its Prediction Tools
- b) Software for the Prediction of physical properties of proteins
PART – C
Answer the following, each not exceeding 1500 words.
Draw diagrams / flow charts wherever necessary (2×20=40 marks)
- (a) What is Homology Modelling? Explain briefly about the Steps involved in it ?
(OR)
- Explain in detail about Secondary Structure of
- (a) Explain briefly about Genomic Comparisons. Add a steps and tools involved in it
(OR)
- b) Explain about the primary and secondary databases.