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Loyola College M.Sc. Zoology April 2003 Bioinformatics Question Paper PDF Download

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LOYOLA  COLLEGE (AUTONOMOUS), CHENNAI-600 034.

M.Sc. DEGREE  EXAMINATION  – ZOOLOGY

fourth SEMESTER  – APRIL 2003

ZO 4804 /  Z  1021   bioinformatics

29.04.2003

1.00 – 4.00                                                                                          Max: 100 Marks

 

SECTION – A                                 (10 ´2 = 20 Marks)

Answer all the questions

 

  1. Comment on pairwise alignment.
  2. Differentiate ONLINE and OFFLINE information.
  3. Expand FTML under FTP.
  4. What is accession number?
  5. Give the codes for the following sites:

(a) Commercial   (b) Government (c) Education   (d) Military

  1. Comment on “Medline”.
  2. What you meant by “Heuristic”.
  3. Define Biochips
  4. What you mean by VSNL?
  5. Comment on metal protein.

 

Section – B                                 (4 ´ 10 = 40 Marks)

Answer any four questions

 

  1. Describe the role of E-mail in information Technology.
  2. Write an account on CD-
  3. Briefly describe the nature and role of ‘information’.
  4. Discus the role of operating system in the computer applications.
  5. Describe ‘nucleus ultra structural information with computational approach’.
  6. Briefly explain the construction of phylogenetic tree.

 

SECTION – C                                (2 ´ 20 = 40 Marks)

Answer any two questions

 

  1. Discuss the dynamic programming in sequence alignment.
  2. Describe the salient features of the Database in the biological researches
  3. Discuss the human genome project in the context bioinformatics.
  4. Discuss the process of predicting the redox state of cysteines in proteins from multiples sequence alignment.

 

 

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Loyola College M.Sc. Zoology April 2006 Bioinformatics Question Paper PDF Download

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             LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – ZOOLOGY

TS 33

FOURTH SEMESTER – APRIL 2006

                                                            ZO 4806 – BIOINFORMATICS

 

 

Date & Time : 27-04-2006/9.00-12.00         Dept. No.                                                       Max. : 100 Marks

 

 

Part A                               (Answer All)                                      10 ´ 2 = 20

  1. What do you mean by online and offline information?
  2. What are the roles of Multimedia in education?
  3. Give the significance of E-mail
  4. Comment on metal binding proteins.
  5. Differentiate rooted and unrooted phylogenetic tree?
  6. What do you mean by MSA?
  7. Comment on pair wise alignment?
  8. What is meant by accession number?
  9. What do you mean by threading?
  10. What is a biochip?

Part B                               (Answer any four)                             4 ´ 10 = 40

  1. Briefly describe the operating system in the computer.
  2. Bioinformatics is a typical example for Multidisciplinary subject – Discuss
  3. Explain the sources of information in the electronic era.
  4. Write an essay on Phylogenetic tree?
  5. Define pair wise alignment with its mechanism?
  6. Discuss the dynamic programming in sequence alignment.

Part C                               (Answer any two)                              2 ´ 20 = 40

  1. Discuss the various aspects of Internet in the information scenario.
  2. Discuss the Human Genome project in the context of Bioinformatics
  3. Describe the methods and concept in data base development.
  4. Describe the Multiple Sequence Alignment with a note on Metallothionein.

 

 

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Loyola College M.Sc. Zoology April 2007 Bioinformatics Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

TS 38

M.Sc. DEGREE EXAMINATION – ZOOLOGY

FOURTH SEMESTER – APRIL 2007

ZO 4806 / 4804 – BIOINFORMATICS

 

 

 

Date & Time: 25/04/2007 / 9:00 – 12:00      Dept. No.                                       Max. : 100 Marks

 

 

PART – A

 

Answer all the questions:                                                                         10 x 2 = 20

 

  1. Define Algorithms.
  2. What do you mean by online and offline information
  3. Comment on Microarray
  4. What do you mean by Computational biology?
  5. Differentiate rooted and unrooted phylogenetic tree?
  6. Comments on Multimedia
  7. Differentiate Software and Hardware
  8. What do you mean by accession number?
  9. Define chaperone.
  10. Give the function of E-mail

 

PART – B

 

Answer any four of the following                                                             4 x 10 = 40

 

  1. Describe briefly the operating system in the computer.
  2. Explain the method of construction of phylogenetic tree?
  3. Bioinformatics is a typical example for Multidisciplinary subject – Discuss.
  4. Explain the application part of Bioinformatics.
  5. Discuss the Pairwise Alignment.
  6. Discuss the human genome project.

 

 

PART – C

 

Answer any Two of the following                                                             2 x 20 = 40

 

  1. Discuss the various aspects of Internet in the information scenario.
  2. Elaborate the Various Factors involved in Drug Designing through bioinformatics procedure.
  3. Describe the methods and concept in data base development.
  4. Explain the multiple sequence alignment with special reference to metallothionein.

 

 

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Loyola College B.Sc. Plant Biology and Biotechnology April 2008 Bioinformatics Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

      B.Sc. DEGREE EXAMINATION – PHYSICS & PL.BIO.& BIOTECH.

DE 8

 

FOURTH SEMESTER – APRIL 2008

AZ 4200 / 4202 – BIOINFORMATICS

 

 

 

Date : 24/04/2008                Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

PART–A

Answer   ALL the  questions                                                                (10 x 2 =20)

  1. What is computational biology?
  2. State ‘FASTA FORMAT’
  3. What is biological data mining?
  4. Distinguish alpha helix from beta pleat.
  5. Define Tanimoto coefficient.
  6. How do you down load Rasmol?
  7. What are logical operators? Mention any two of them.
  8. Name various types of Amino acids found in the biosystem.
  9. Comment on Phylip and SOPMA
  10. Expand PUBMED and  EXPASY.

PART-B

Answer any FOUR  of the following                                                             (4X10=40)

  1. Describe Sanger method of sequencing.
  2. State the applications of human genome project.
  3. When will you perform BLAST and CLUSTAL ‘W’? What would be the output?
  4. Highlight the principle and application of microarray.
  5. Demonstrate primary and secondary structure analysis of a protein using relevant tools
  6. Write down a program in C to find the biggest of three numbers using logical operators.

PART-C

Answer any TWO of the following                                                    (2X20=40)

  1. Propose a protocol for each of southern  blotting and DNA finger printing techniques.
  2. Give an account on biological data bases and explain the tools associated for     analysis
  3. Classify proteins based on structure.  How do you view them using bioinformatics tools.
  1. Highlight the following in view of pharmainformatics: a) Target indentification and validation b)

Compound optimization   c) QSAR    d) Docking algorithm

 

 

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Loyola College B.Sc. Plant Biology and Biotechnology Nov 2008 Bioinformatics Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.

ED 13

 

FIFTH SEMESTER – November 2008

PB 5407/PB 5404 – BIOINFORMATICS

 

 

 

Date : 14-11-08                     Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

                                                                 PART – A                                                        (20 marks)

Answer ALL questions.                                                                        

 

I  Choose the correct answer                                                                                           (5×1= 5 marks)

 

  1. Software used for drug designing
  2. INSIGHTII b)  GENSCAN  c)  GLIMMER  d) GRAIL
  3. Software used for gene expression analysis
  4. GENOVIZ b)  GENSCAN  c)  GLIMMER  d) GRAIL
  5. Database for structural classicification of proteins
  6. SCOP b) CATH  c) SGD  d) PROSITE
  7. Tool used for homology modelling
  8. a) MODELLER b) PIPMAKER  c) AUTODOCK  d) INSIGHTII
  9. Tool used for pathway analysis
  10. KEGG b) MODELLER   c)  AUTODOCK d)  INSIGHTII

 

II  State whether the following true or false :                                                              (5×1= 5 marks)

  • ________ is termed as non coding region.
  • ________ is a tool for the gene prediction in microbial genomes.
  • The size of the Homa sapien  genome is _________.
  • Clustalw developed by ___________.
  • ________ is a database for domains & protein families.

 

II  Complete the following:                                                                                              (5×1=5 marks)

 

  • —————- is  a Restriction Site tool.
  • ———— is Splice Site Prediction tool
  • Rasmol is—————-.
  • ————– is multiple sequence alignment tool.
  • DDBJ is maintained by——————-.

 

IV  Write notes on the following, each not exceeding 50 words.                              (5×1=5 marks)

 

  • Write notes on Restriction site
  • Define Swiss-model
  • Difference between Local & Global alignment
  • Comment on BLAST
  • Define INTERNET.

 

PART – B

 

Answer any FIVE of the following, each not exceeding 350 words (8×5= 40 marks)

Draw diagrams / flow charts wherever necessary.

 

  •  Explain the Post Translational Modifications of proteins  with a appropriate example.
  • Explain the principles, types of
  • What are the levels of protein structure & explain them briefly with a appropriate diagram
  • Write notes on a) Paralogs b) Orthologs d) Steps  involved in  Phylogenetic Analysis.
  • Explain briefly about S-W algorithm & add on differences between N-W & S-W algorithm
  • Explain any two important online journal databases briefly.
  • Write briefly about Genomic databases
  • Give short notes on
  1. a) Splicing and its Prediction Tools
  2. b) Software for the Prediction of physical properties of proteins          

 

PART – C

 

Answer the following, each not exceeding 1500 words.

Draw diagrams / flow charts wherever necessary                                                (2×20=40 marks)

  • (a) What is Homology Modelling? Explain briefly about the Steps involved in it ?

(OR)

  • Explain in detail about Secondary Structure of
  1. (a) Explain briefly about Genomic Comparisons. Add a steps and  tools  involved in it

(OR)

  1. b) Explain about the primary and  secondary databases. 

 

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Loyola College B.Sc. Plant Biology and Biotechnology April 2009 Bioinformatics Question Paper PDF Download

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     LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.

VE 15

FIFTH SEMESTER – April 2009

PB 5407 / PB 5404 – BIOINFORMATICS

 

 

 

Date & Time: 04/05/2009 / 1:00 – 4:00       Dept. No.                                                       Max. : 100 Marks

 

 

PART – A

  1. Choose the correct answer. (5 x 1 = 5)
  1. Multiple sequence alignment is an extension of ——– alignment.
  1. Pairwise Local           c. Global          d. Random

 

  1. Exon is a ————- sequence
  1. Nucleic acid Protein         c. Pairwise       d. Multiple

 

  1. Splice sites are predicted using —————-.
  1. Netgene2 Nebcutter2.0           c. Signalp        d. Pfam

 

  1. Blastx is used to search ———- database using a translated nucleic acid query.
  1. Protein Nucleic acid            c. Translated    d. mRNA

 

  1. Pfam is a collection of  ————- alignment.
  1. Multiple sequence Single          c. Protein         d. Nucleotide

 

  1. State whether the following statements are true or false. (5 x1= 5)
  1. Dot plot is a graphical method for comparison of two biological sequences.
  2. Global alignment is used to align every residue in all sequences.
  3. Pairwise – local alignment is used to find the best matching sequences.
  4. ClustalW is an sequence alignment software.
  5. Intron is also termed as non-intervening sequences.

 

III. Complete the following.                                                               (5 x 1 = 5)

  1. Exon contains a part of the ————— that codes for a specific sequence.
  2. FASTA format also termed as ——————— format.
  3. MEDLINE  can be expanded as ———————.
  4. RASMOL is a —————- visualizing tool.
  5. ————- makes extensive use of sequence alignments in the construction and interpretation of species relationships.

 

  1. Answer the following in about 50 words each. (5 x 1=5)

Define / Explain:

  1. Sticky end cut
  2. Motif
  3. Splice site
  4. DIP
  5. Genscan

 

 

PART – B

Answer any FIVE of the following, each not exceeding 350 words.                        (5 x 8 =40)

 

  1. Write notes on the biological sequences of nucleotides and proteins.
  2. List out the applications of alignments and add a note on Needleman and Wunch algorithms.
  3. Explain about FASTA and its types.
  4. Discuss about the software used for the prediction of transition tools.
  5. Write notes on Pfam and Prosite profiles.
  6. Explain about different post translational modifications.
  7. Describe the usefulness of RASMOL.
  8. With illustrations explain DOT-PLOT.

 

PART – C

Answer any TWO of the following, each not exceeding 1500 words.          (2 x 20 = 40)

 

  1. (a) Explain about Homology modeling, PubMed, Medline and Swissmodel.

Or

(b) Discuss on how to identify Motifs and Restriction sites.

  1. (a) Explain Pairwise – Local alignment, ClustalW and Global alignment.

Or

(b) Write notes on softwares used in biological databases.

 

 

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Loyola College B.Sc. Plant Biology and Biotechnology April 2012 Bioinformatics Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – PLANT BIOLOGY & PLANT BIO-TECH.

FIFTH SEMESTER – APRIL 2012

PB 5407 – BIOINFORMATICS

 

 

 

Date : 27-04-2012              Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

PART-A

 

Answer the following each within 50 words:                                                                              (10×2=20)

 

  1. What is SWISSPROT?
  2. What is a quaternary structure of a protein?
  3. What are the applications of BLAST?
  4. Define Dot-matrix.
  5. Explain ORF.
  6. Differentiate between exons and introns.
  7. What are motifs?
  8. List four protein interaction databases.
  9. What is a 3D structure of a protein?
  10. What is homology modeling?

 

 

PART-B

Answer the following each answer within 500 words; Draw diagrams wherever

Necessary:

                                                                                                                                                  (5×7=35)

11.(a) What is a biological database? Explain nucleic acid databases in detail.

OR

(b) Explain the different structural levels of a protein.

12.(a) Differentiate between pair wise alignment and global alignment.

OR

(b) List out the application of alignments.

13.(a) What is a restriction enzyme? Give an algorithm to predict the restriction sites in a protein

sequence.

OR

(b) Give an account on genomic database.

14.(a) Explain any three post translational modifications of a protein.

OR

(b) Briefly explain about Pfam.

15.(a) Give a detailed description on molecular modeling and the techniques used for analysis.

OR

(b) Write notes on PubMed and MedLine.

 

 

 

 

 

 

 

 

PART-C

Answer any THREE of the following, each answer within 1200 words; Draw diagrams wherever necessary:                                                                                                                         (3×15=45)

 

  1. Explain protein sequence databases in detail.

 

  1. Draw a dynamic programming algorithm for ABCNJRCLCRPM

AJCJNCKCLRBP

 

  1. Explain the soft ware used for prediction of physical properties of nucleic acid sequence.

 

  1. What are signal peptides? Write a note on motif based databases.

 

  1. Give an account on RASMOL.

 

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Loyola College B.Sc. Plant Biology and Biotechnology April 2015 Bioinformatics Question Paper PDF Download

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Loyola College B.Sc. Plant Biology and Biotechnology April 2016 Bioinformatics Question Paper PDF Download

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Loyola College B.Sc. Plant Biology and Biotechnology Nov 2016 Bioinformatics Question Paper PDF Download

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Loyola College B.Sc. Adv. Zoology & Bio-Technology April 2015 Bioinformatics Question Paper PDF Download

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Loyola College B.Sc. Adv. Zoology & Bio-Technology April 2016 Bioinformatics Question Paper PDF Download

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Loyola College B.Sc. Computer Science April 2011 Bioinformatics – II (Genomics & Proteomics) Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – COMPUTER SCI. APPL., PHYSICS

FOURTH SEMESTER – APRIL 2011

PB 4208 / 4213  – BIOINFORMATICS – II (GENOMICS & PROTEOMICS)

 

 

Date : 05-04-2011              Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

 

Answer all questions                                                                                                       (20marks)

I Choose the correct answer                                                                                           (5 x 1 = 5)

 

  1. A codon is a series of __________ nucleotide.
  2. 1           b) 3                                   c) 5                                  d) 4
  3. Electrophoresis is carried out at _________ temperature.
  4. 80ºC                  b) 70ºC                              c) 50ºC                           d) 20 ºC
  5. The genome size of Arabidopsis thaliana is
  6. 125Mb           b) 3300Mb                         c) 0.58Mb                      d) 466Mb
  7. ______________ pathway turns the gene on or off.
  8. Metabolic b) Gene regulation           c) Biological                  d) Cell signaling
  9. Sequencing of ____________ was done in the year 1997.
  10. coli                  b) S.cerevisiae                  c) M.musculus               d) Fugurubripes

 

II Say whether the following statements are True or False                                        (5 x 1 = 5)

 

  1. ATG is stop codon.
  2. InterPro is a cross reference of several protein family databases.
  3. BLAST is Basic Local Algorithm Search Tool.
  4. Topology refers to both the orientation and connectivity of secondary structures.
  5. OrthoMCL is a database for mammals.

 

III Complete the following                                                                                             (5 x 1 = 5)

 

  1. The biological information contained in a genome is programmed in its _______.
  2. RNA is synthesized from DNA through a process known as __________.
  3. _________ model is used to find & classify genes of different types.
  4. Protein Data Bank was generated by ______________.
  5. _______________ database consists of 30programs and is a command line program.

 

 

IV Answer in one or two sentences, each in about 50 words                                      (5 x 1 = 5)

 

  1. Define spliceosome.
  2. Write any two applications of DNA sequencing.
  3. Differentiate between sensitivity and specificity.
  4. Define hydrogen bonding.
  5. Differentiate between orthologous and paralogous.

 

 

 

 

Section B

 

V Answer any FIVE of the following, each in about 350 words                               (5 x 8 = 40)      

 

  1. Write notes on:
  2. i) ORF
  3.     ii) Alternative splicing
  4. Briefly explain Dideoxynucleotide method.
  5. Write short note on Promoter elements.
  6. Briefly explain microbial genome database and Karyn’s genome database.
  7. Write notes on inter-molecular interactions.
  8. What is a biological pathway? Explain the different types.
  9. Briefly explain DNA microarray with suitable diagram.
  10. Draw a dynamic programming using Needlemann algorithm for the following

sequence.

Sequence1: GATCTA

Sequence2: GATCA

 

 

 

Section C

 

VI Answer the following, each in about 1500 words                                                (2 x 20 = 40)

 

  1. (a) Explain any five protein family databases

OR

(b) Explain how to find genes in large genomes

 

  1. (a) Define post-translational modification and explain the various modifications

                                                      

 

OR

(b) What is Human Genome Project? Explain its types, goals and applications

 

 

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Loyola College B.Sc. Chemistry Nov 2006 Bioinformatics Question Paper PDF Download

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             LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034  B.Sc. DEGREE EXAMINATION – CHEMISTRY

AE 04

THIRD SEMESTER – NOV 2006

         PB 3202 – BIOINFORMATICS

 

 

Date & Time : 31-10-2006/9.00-12.00         Dept. No.                                                       Max. : 100 Marks

 

 

 

 

Part A

Answer all the questions                                                                              (20 marks)

 

I      Choose the correct answer                                                                  (5 x1  = 5)

 

  1. Pubmed is a ________ database.

a)gene             b) sequence                  c) journal             d) disease.

  1. ________ is a protein structure visualization tool.
  2. a) rasmol b) genbank       c)  bioedit            d) NCBI
  3. PDB is a ________ database.
  4. a) sequence b) structure   c) pathway          d) journal.
  5. Pattern is a representation of ________.
  6. a) gene   b) structure             c) motif             d) genome
  7. Alpha helix is a protein________ structure.
  8. a) primary b) secondary                 c) tertiary           d) quarternary.

 

 

II State True or False                                                                                    (5 x 1  =5)

 

  1. X represents any aminoacid in a pattern.
  2. Blastp is used for searching protein sequences in databases.
  3. Beta sheet is a tertiary structure.
  4. Protein structure can be downloaded from Rasmol.
  5. Genscan is used for protein structure analysis..

III  Complete the following                                                                (5 x 1 = 5)

 

  1. ________ is the RNA which transfers the aminoacids.
  2. The double helical structure of DNA was proposed by ________.
  3. Swissprot is a protein________ database.
  4. Fasta format begins with a ________ symbol.
  5. ________ is the software for multiple sequence alignment..

 

 

 

 

 

 

 

IV Answer  the following, each in 50 words                                   .             (5 x  1 = 5)

 

  1. What is Accession number.
  2. What is Genetic codon.
  3. Explain : Restriction enzymes.
  4. What are Purines.
  5. Define : GC%.

PART B

 

Answer any Five of the following , each in about 350 words.                 (5 x 8 =40)

 

  1. Explain NCBI, DDBJ and EMBL.
  2. Discuss the applications of Bioinformatics.
  3. Explain Genscan and its applications. .
  4. Explain the double helical structure of DNA.
  5. Ezplain the secondary structure prediction tool .(sopma or nnpredict).
  6. Ezplain any 5 commands in Rasmol.
  7. Describe ORF finder in detail.
  8. Explain a software for nucleic acid sequence analysis.

PART C

 

Answer any Two of the following, each  in about 1500 words.               (2 x 20 = 40)

Draw diagrams / flowcharts wherever necessary.

 

 

29.a) Explain Genbank and its file format.

Or

29..b) Explain BLAST,  its types and significance.

 

30.a) Explain about  protein synthesis in detail.

Or

30.b) Explain any two protein sequence databases.

 

 

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“Loyola College B.Sc. Chemistry Nov 2008 Bioinformatics – I Question Paper PDF Download”

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

       B.Sc. DEGREE EXAMINATION –MATHS & PHYSICS, CHEMISTRY

ED 04

 

THIRD SEMESTER – November 2008

PB 3204/PB 3202 – BIOINFORMATICS – I

 

 

 

Date : 13-11-08                     Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

PART A

 

Answer ALLl the questions                                                                                                             (20 marks)

 

  1. Choose the best answer (5X1=5)

 

  1. The database for retrieving information on genetic disorders in man is
  2. a) OMIM b) OMIA c) Medline Plus           d) Pubmed
  3. Basic proteins of chromosomes are
  4. a) histones b)histidine c)globin           d)globulin

3.7-Methyl guanosine is added to the nucleotide sequence in

a)5’ end           b) 3’ end          c)intron            d) exon

  1. ORF finder translates the sequence in
  2. a) 6 frames b) 5 frames c) 64 frames    d) 20 frames
  3. A software for identifying restriction site is
  4. a) Neb Cutter b)Rasmol c)Cn3D           d)GRAIL

 

  1. State whether the following true or false (5X1=5)

 

  1. Rough endoplasmic reticulum is the region of protein synthesis.
  2. RefSeq serves as a standard for genomic analyses.
  3. Entrez is a SRS of NCBI.
  4. Rosalind Franklin provided X-ray crystallographic data of DNA to Watson and Crick for elucidating double helical model.
  5. One letter code of Tryptophan is G.

 

III. Complete the following                                                                                                              (5X1=5)

 

  1. Pubchem substance is a ___________ database.
  2. KEGG is a________ database.

13.__________ is compatible with Rasmol.

  1. Lalign is a ________ alignment tool.
  2. Shannon’s Noise in replication refers to _________.

 

  1. Answer the following, each not exceeding 50 words. (5X1=5)

 

  1. Mention any two differences between prokaryote and eukaryote.
  2. Differentiate BLAST and FASTA.
  3. What is a Protein Motif.?
  4. What is MapViewer?
  5. Write about Composite Databases.

 

 

 

 

 

PART  B

                                                                                                                       

Answer any five of the following, each not exceeding 350 words.                                                (5X8=40)

 

Draw diagrams and flowcharts wherever necessary.

 

  1. Explain the primary databases in detail.
  2. What is PDB and what are its features?
  3. Discuss about Human Genome Project and the genesis of bioinformatics tools.
  4. Write about enzyme databases and its features.
  5. How is the GenBank flatfile organized and write about header and features table?
  6. Briefly discuss about DNA replication.
  7. Write about proteomic tools including Compute pI/MW and Signal P.
  8. How is the protein secondary structure organized into Alpha helix and Beta strands?

 

PART C

 

Answer the following, each not exceeding 1500 words                                                                 (2X20=40)

Draw diagrams and flowcharts wherever necessary.

 

  1. a) Elaborate upon BLAST, its parameters, types and applications

 

(OR)

 

  1. b) Align the following sequences using Needleman Wunsch algorithm

Seq 1: ACTCG

Seq 2: ACAGTAG

 

  1. a) Discuss about protein signature prediction by defining Motif, Domain, Family and Signature .List the

databases from which the details can be retrieved.

 

(OR)

 

  1. b) Explain the structure visualization tools including Homology Modeling.

 

 

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“Loyola College B.Sc. Chemistry April 2009 Bioinformatics – I Question Paper PDF Download”

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     LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

B.Sc. DEGREE EXAMINATION – CHEMISTRY.

VE 06

THIRD SEMESTER – April 2009

PB 3204 – BIOINFORMATICS – I

 

 

 

Date & Time: 16/04/2009 / 1:00 – 4:00         Dept. No.                                                       Max. : 100 Marks

 

 

 

PART A

 

Answer all the questions                                                       (20 marks)

 

  1. Choose the best answer (5X1=5)

 

Answer all the questions

  1. Data model used in bioinformatics application is
  2. a) hierarchial b)relational c)network d)multidimensional
  3. NCBI hosts
  4. a) BLAST b) FASTA c)DDBJ           d)Lalign
  5. Aromatic aminoacids are
  6. a) tyrosine and tryptophan
  7. b) tyrosine and threonine
  8. c) phenylalanine and alanine
  9. d) phenylalanine and leucine
  10. Double helical model of DNA was published by
  11. a) Watson and Crick
  12. b) Linus Pauling and Crick
  13. c) Rosalind Franklin and Crick
  14. d) Corey and Watson
  15. Addition of adenine to mRNA is called
  16. a) 3’ modification
  17. b) 5’ modification
  18. c) Poly A tailing
  19. d) Polymerase Chain reaction

 

  1. State whether the following true or false (5X1=5)

 

  1. Chargaff rule says A=T and G=C.
  2. Removal of introns and reunioin of exons is called Splicing.
  3. RefSeq is a standard database for comparative analyses.
  4. Cn3D is compatible with PDB.

10.NebCutter tool identifies restriction sites.

 

 

 

 

III. Complete the following                                                                          (5X1=5)

 

  1. Proline and glycine are found in _______ of protein secondary structure.
  2. Proof reading function of polymerase is due to________ activity.
  3. PubChem Substance is a _________ database.

 

14._________ are produced by gene duplication within a species but has different functions.

  1. The latest genome sequenced is from an endangered species _______.

 

  1. Answer the following, each not exceeding 50 words. (5X1=5)

 

  1. Compute pI/MW
  2. Expand HSP
  3. What is a Start codon?
  4. Define DotPlot
  5. What is a Rooted Phylogenetic Tree?

 

PART B

                                                                                    (5X8=40)

Answer any five of the following, each not exceeding 350 words.

Draw diagrams and flowcharts wherever necessary.

 

  1. Explain OMIM and its features.
  2. What are the features of PDB?
  3. Discuss about BLAST and its types.
  4. How will you analyze the gene structure in eukaryotes using software tools?
  5. List the databases involved in Protein Domain analyses.
  6. Explain about proteomic tools.
  7. Detail the various molecular visualization tools with emphasis on Homology modeling.
  8. Write about ORF finder of NCBI.

 

PART C

Answer the following, each not exceeding 1500 words                  (2X20=40)

Draw diagrams and flowcharts wherever necessary.

 

29a) Explain Smith Waterman Local Algorithm by aligning the following sequences

ACG TAT CGC GTA TA

GAT GCT CTC GGA AA

Or

  1. b) Elaborate upon Multiple Sequence alignment and its software tools.

 

30 a) Write about the mechanism of translation of protein in detail.

Or

  1. b) How does the process of DNA replication occur inside the cell?

 

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