LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

FIRST SEMESTER – NOV 2006

ML 1809 – MOLECULAR BIOLOGY

Date & Time : 31-10-2006/1.00-4.00       Dept. No.                                                       Max. : 100 Marks

SECTION-A

Answer all the questions                                                       2X10=20marks

1. Mention the role of topoisomerases?
2. Draw the secondary structure of t-RNA
3. What is Chargaff’s rule?
4. Write notes on a) heterochromatin b) euchromatin
5. List the different kinds of lysosomes and their functions
6. What is RNA polymerase holoenzyme?
7. What is photoreactivation repair mechanism?
8.  Expand the abbreviations

1. a) APC b) CDKS

1. What is the role of tyrosine kinases in cancer?
2.  What is Turner’s syndrome?

SECTION-B

Answer any four of the following                                        4X10=40marks

1. Explain the special constraints relevant to genetic testing
2. Explain the molecular structure of double stranded DNA.
3. Describe the mechanism of transcription in eukaryotes.
4. What are leading and lagging strands? List out the enzymes of DNA replication and their functions.
5. Write a short note on viral oncogene.
6. Give an account of on excision and recombination repair mechanisms.

SECTION-C

Answer any two of the following                                         2X20=40marks.

1. Draw the eukaryotic cell and write notes on a) endoplasmic reticulum.

1. b) golgi complex c) mitochondria.

1. Explain in detail the process of protein synthesis in prokaryotes.
2. Describe in detail the regulation of eukaryotic cell cycle.
3. Explain in detail the active transport of materials across plasma membrane.

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1809 – MOLECULAR BIOLOGY

Date : 08-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION –A

Answer ALL the following.                                                                                 (10 x 2 = 20 marks)

1. Expand a) ASR b) CPT   c) ABCC   d) TWGDAM.
2. What is RNA polymerase holoenzyme?
3. Define chargaff’s rule of molar equivalence.
4. Differentiate poly glutamine from non-poly glutamine disease.
5. What are the clinical symptoms of xeroderma pigmentosum?
6. Distinguish cisterns from crista.
7. Define nucleic acid hybridization.
8. Mention the role of catalase and oxidase in peroxisomes.
9. What are the rare forms of sickle cell disease?
10. Distinguish oncogenes from proto-oncogenes

SECTION – B

Answer any FOUR of the following.                                                                (4 x 10=40 marks)

11. Explain the models of plasma membrane.
12. Give an account on cytoskeleton, cilia, flagella and ribosome.
13. Describe genetic code.
14. Describe in detail the structure of DNA and the separation of strands.
15. Give an account on the functional elements of chromosomes.
16. Explain the translocation of mutation in Chronic myelogenous leukemia, Burkitt’s lymphoma and Wilm’s tumor.

SECTION – C

Answer any TWO of the following.                                                                  (2 x 20=40 marks)

17. Explain the mechanism of replication.
18. With a neat flow chart for establishing the molecular diagnostic laboratory, explain Laboratory design and Laboratory personnel.
19. What are syndromes? Explain Duchenne muscular dystrophy and Prader – willi syndrome.
20. Describe the types of gene mutations

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        LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – April 2009

ML 1809 – MOLECULAR BIOLOGY

Date & Time: 28/04/2009 / 1:00 – 4:00  Dept. No.                                                   Max. : 100 Marks

SECTION –A

Answer ALL the following.                                                                     10 x 2 =20 marks

1. Draw the structure of nucleus and add a note on it.
2. Expand a) FDA b) CLIA  c) ASCLD  d) CDC.
3. What is the difference between prader – willi syndrome and angelman syndrome?
4. List the different classes of Oncogene.
5. Mention the role played by CFTR in human body.
6. Write the difference between rho-dependent and rho-independent terminators.
7. Write the original wobble predictions.
8. Define mutagen.
9. Mention the role played by DNA unwinding proteins
10. What are types of euploidy?

SECTION B

Answer any FOUR of the following.                                                    4 x 10=40 marks

11. Explain the structure and function of RNA.
12. Describe cystic fibrosis in detail.
13. Explain the forensic identity testing by DNA analysis.
14. Describe the four rules that govern the synthesis of bio-polymers with illustrations.
15. Give an account on Sickle cell anaemia.
16. Describe the three common DNA excision repair mechanisms in our body.

SECTION-C

Answer any TWO of the following.                                                      2 x 20=40 marks

17. Explain the mechanism of translation.
18. Describe the translocation of mutations in various types of cancer
19. Draw the structure of eukaryotic cell and explain a) Golgi bodies b) Mitochondria

c)Lysosomes

20. Explain the morphology and functional elements of eukaryotic chromosomes

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECHNOLOGY

FIRST SEMESTER – NOVEMBER 2012

ML 1809 – MOLECULAR BIOLOGY

Date : 06/11/2012            Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

PART  A

Answer ALL  questions:                                                                            10 x 2 = 20

1. What is RNA polymerase holoenzyme?
2. Mention the role of enzymes in peroxisomes.
3. What are oncogenes and proto-oncogenes?
4. Draw the structure of nucleus and label the parts.
5. Differentiate rho-dependent from rho-independent terminators.
6. What are mutagens?
7. What is angelman syndrome?
8. Distinguish euploidy from aneuploidy.
9. Define nucleic acid hybridization.
10. Comment on sickle cell disease.

PART  B

Answer any FOUR questions:                                                                   4 x 10 = 40

11. Explain plasma membrane models.
12. Explain the structure and function of RNA.
13. Characterize genetic code.
14. Explain structure of DNA.
15. Describe cystic fibrosis.
16. Explain DNA excision repair mechanisms.

PART  C

Answer any TWO questions:                                                                   2 x 20 = 40

17. Describe translocation mutations in various types of cancer.
18. Draw the structure of eukaryotic cell and explain the structure Mitochondria

and Lysosomes.

19. Explain the mechanism of DNA replication.
20. Write an essay on eukaryotic chromosomes.

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