M.Sc Medical Lab Technology Question Paper

Loyola College M.Sc. Medical Lab Technology April 2008 Statistical Applications In Biological Sciences Question Paper PDF Download

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NO 47

 

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – BIO INST & MED.LAB TECH

THIRD SEMESTER – APRIL 2008

         ST 3901 – STATISTICAL APPLICATIONS IN BIOLOGICAL SCIENCES

 

 

 

Date : 05-05-08                  Dept. No.                                        Max. : 100 Marks

   Time : 9:00 – 12:00

PART A

Answer all the questions.                                                                  5 X 2 = 10

  1. Define biostatistics.
  2. What are the merits of arithmetic mean?
  3. What measures are available in measure of dispersion?
  4. Define correlation.
  5. Write any two properties of regression.
  6. What is population and sample?
  7. What do you mean about two-sample t-test in health science?
  8. What is analysis of variance?
  9. Distinguish between  sampling error and non-sampling error.
  1. Explain simple random sampling by illustration.

PART B

Answer any FIVE questions.                                                                       5 X 8 = 40

 

  1. Compute mean and median for the following data:

Age                 : 20-30   30-40   40-50   50-60   60-70   70-80   80-90

Number of patients     :    15        19        11          25        22        10         5

  1. Calculate correlation coefficient for weights (kg) and heights (cm)  of  10 patients in Seahorse hospital.

Weight :  83    99       63       71       65       70       69       56       66       88

Height  : 185   180      173      168      175      183      174      164      169      205

 

  1. The following data are the oxygen uptakes (milliliters) during incubation of a random sample of 15 cell suspensions.

14.0     14.1     14.5     13.2     11.2     14.0     14.1     12.2     11.1     13.7     13.2

16.0     12.8     14.4     12.9

Do these data provide sufficient evidence at the 0.05 level of significance that the population mean is not 12ml?

 

  1. Cortisol level determinations were made on two samples of women at childbirth. Group 1 subjects underwent emergency cesarean section following induced labor. Group 2 subjects delivered by either cesarean section or the vaginal route following spontaneous labor. The sample sizes, mean cortisol levels, and standard deviations were as follows:

Sample                        n          mean    standard deviation

1                 10            435              65

2                 12            645              80

Use two sample t-test to provide sufficient evidence to indicate a difference in the

mean cortisol level in the populations represented? Let a = 0.05.

 

  1. Explain any four methods of sampling and give example for each.

 

  1. Four subjects participated in an experiment to compare three methods of relieving stress. Each subject was placed in a stressful situation on three different occasions. Each time a different method for reducing stress was used with the subject. The response variable is the amount of decrease in stress level as measured before and after treatment application. The results were as follows.
 

Subject

 Treatment
A B C
1 16 26 22
2 16 20 23
3 17 21 22
4 28 29 36

Can we conclude from these data that the three methods differ in effectiveness? Let a = 0.05.

  1. Explain various steps in involved in Hypothesis testing.
  2. Explain any four important measures of dispersion.

 

PART C

Answer any two questions.                                                                2 X 20 = 40

 

  1. The following are the number of babies born during a year in 60 community hospitals.

30        55        27        45        56        48        45        49        32        57        47        56        37        55            52        34        54        42        32        59        35        46        24        57        32        26        40        28            53        54        29        42        42        54        53        59        39        56        59        58        49        53            30        53        21        34        28        50        52        57        43        46        54        31        22        31            24        24        57        29        2          18        25        6          9          15        23        46        11        22

From these data construct:

a). A frequency distribution with the class interval 0-10, 10-20, 20-30, 30-40,

40-50, 50-60

b). Histogram.

c). Frequency polygon.

d). Frequency curve

 

  1. Consider the following Bivariate data:

X:  3.31  2.41   2.11  3.01  2.13  2.41  2.10  2.41  2.09  3.00

 

Y: 4.09  3.84   2.97  3.22  3.96  2.76  3.42  3.38  3.28  2.93

a). Find two regression equations describing the relationship between the two

variables.

b). Compute r2 and give your interpretation.

c). Estimate X when Y = 2.00 and Y when X = 2.80.

 

  1. [i] The Weights (in Kg.) of  9 Obese Women before and after 12-weeks of

VLCD (very low calorie diet) treatment  are given in following table. Test whether

these data provide sufficient evidence to allow us to conclude that the treatment is

effective in causing weight reduction in obese women? Let a=0.05

Before  : 117.3    114.4      98.6    104.3   105.4   100.4   81.7   89.5   78.2

After    :  83.8      85.9        75.8    82.9     82.3      77.7    62.7   69.0   63.9

[ii] In a study of nutrition care , it is found that among 55 patients with hypertension, 24 were on sodium-restricted diet. Of 149 patients without hypertension, 36 were on sodium-restricted diets. May we conclude that the proportion of patients on sodium-restricted diet is higher among patients with hypertension than among patients without hypertension?

 

  1. A physical therapist wished to compare three methods teaching for patients to use a certain prosthetic device. He felt that the rate of learning would be different for patients of different ages and wished to design an experiment in which the influence of age could be taken into account.

 

Age Group Teaching Method
 

Under 20

 A B C
7 9 10
20 to 29 8 9 10
30 to 39 9 9 12
40 to 49 10 9 12
50 and over 11 12 14

 

Use two-way analysis of variance for a = 5 % level and give your interpretation.

 

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Loyola College M.Sc. Medical Lab Technology April 2008 Non-Invasive Techniques Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

LM 16

FOURTH SEMESTER – APRIL 2008

ML 4801 – NON-INVASIVE TECHNIQUES

 

 

 

Date : 16/04/2008            Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

 

SECTION –A

Answer all the following.                                                         10 x 2 = 20 marks

 

  1. List the causes for hyper and hypofluorescence in fluorescein angiography.
  2. What is the purpose of computed tomography?
  3. How the gamma rays are produced in positron emission tomography?
  4. Draw the patterns of bloods flow that can be detected by ultrasonography.
  5. When does atrial fibrillation occurs in electrocardiography?
  6. Define a.)Ametropias b.)Staphylomas
  7. What is the necessary for breast compression in mammmography?
  8. What are the three factors that are responsible for image qualityin magnetic resonance

imaging?

  1. Define Paget’s disease and infective mastitis.

10.Diferentiate protanopia from tritanopia.

 

SECTION B

Answer any four of the following.                                        4 x 10=40 marks

 

  1. Explain the procedure for visual acuity test.
  2. Describe the different modes of examination in ultrasound technology
  3. Give an account on the principle and clinical applications of magnetic resonance imaging.
  4. Explain the different types of leads, the normal and abnormal interpretations of

electrocardiography.

  1. Describe the three types of tests that are performed in evoked potential studies.
  2. Give an account on the purpose, advantages and disadvantages of opthalmoscopy.

 

SECTION-C

Answer any two of the following.                                         2 x 20=40 marks

 

  1. Explain in detail about positron emission tomography.
  2. Describe the principle, procedure and abnormal findings of computed tomography.
  3. Give a detailed account on the procedure, findings and implications of the result of

electroencephalography.

  1. With the neat block diagram, explain the working mechanism, types and advantages of

x-rays.

 

 

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Loyola College M.Sc. Medical Lab Technology April 2008 Immunology Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

LM 07

SECOND SEMESTER – APRIL 2008

ML 2809 – IMMUNOLOGY

 

 

 

Date : 22/04/2008            Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION A

Answer ALL the questions:                                                            (10 x 2 = 20 Marks)

  1. What is MALT?
  2. What are super antigens?
  3. What are Freund’s complete and incomplete antigens?
  4. Mention the biological activities of the subclasses of IgG.
  5. How are grafts classified?
  6. What are the three categories of disease treatable by bone marrow transplantations?
  7. Differentiate attenuated and inactivated vaccines.
  8. What are subunit vaccines?
  9. Define anti idiotype antibody.
  10. What are thymus dependent antigens?

SECTION B

Answer any FOUR of the following                                            (4 x 10 = 40 Marks)

  1. Write briefly on primary lymphoid organs.
  2. Give an account on the structure of MHC molecules.
  3. Give a brief account on monoclonal antibody production. Add a note on its applications.
  4. Give a descriptive account of immune response against protozoan parasites.
  5. Write briefly on the immunosuppressive therapies during transplantation.
  6. Write briefly on the different types of ELISA test.

SECTION C

Answer any TWO of the following                                              (2 x 20 = 40 Marks)

 

  1. Define interleukins. Give an account of the source and functions of IL-1 to IL-20
  2. What is hypersensitivity? Write in detail on IgE mediated hypersensitivity?
  3. Give a detailed schedule of vaccination in childhood and adults.
  4. Explain in detail the different methods involved in demonstration of agglutination reaction.

 

 

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Loyola College M.Sc. Medical Lab Technology April 2008 Human Pathoagens Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

LM 06

SECOND SEMESTER – APRIL 2008

ML 2801 – HUMAN PATHOAGENS

 

 

 

Date : 17/04/2008            Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

 

PART A                                        (Answer All)                               10 ´ 2 = 20

  1. Write four examples of continuous cell lines.
  2. Differentiate pasteurization from flash pasteurization.
  3. Define plague and bacteriophage.
  4. Define quellung reaction.
  5. Define two methods of virus cultivation.
  6. Expand the abbreviations: PCR, LCR, LJ and RFLP.
  7. Differentiate autopsy from biopsy.
  8. Differentiate endotoxins from exotoxins.
  9. Define babes ernst granules and cuneiform arrangement.
  10. List four clinical syndromes caused by Salmonella in human beings.

PART B                                   (Answer any four)                          4 ´ 10 = 40

  1. Briefly describe the life cycle and laboratory diagnosis of Ascaris lumbricoides.
  2. Briefly describe the life cycle and pathogenesis of Entamoeba histolytica.
  3. Write a short note on clinical importance and life cycle of Trypanosoma brucei.
  4. Briefly discuss the life cycle and pathogenesis of pathogen causing malaria
  5. Discuss the principle, procedure, clinical significance and grading for Ziehl Neelsen staining.
  6. Comment on morphology and life cycle of Wuchereria bancrofti.

PART C                                    (Answer any two)                          2 ´ 20 = 40

  1. What is culture medium? Give an account on types of culture media.
  2. What is bacteriophage? Explain the lytic and lysogenic cycles in bacteriophage.
  3. What is a virus? Describe in detail the classification of viruses.
  4. Give an detailed account on life cycle and pathogenesis of Strongyloides stercoralis and Trichomonas vaginalis.

 

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Loyola College M.Sc. Medical Lab Technology April 2008 Histopathology And Essentials Of Lab Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

LM 17

FOURTH SEMESTER – APRIL 2008

ML 4807 – HISTOPATHOLOGY AND ESSENTIALS OF LAB

 

 

 

Date : 21/04/2008            Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

 

SECTION-A

Answer ALL the questions:                                                                           (10 X 2=20 Marks)

 

  1. Write the composition of formal saline fixative.
  2. How will you prepare 650 ml of 0.9N hydrochloric acid solution?
  3. What is exfoliative cytology?
  4. What is cone Biopsy?
  5. List the factors involved in fixation process.
  6. What is a frozen section?
  7. What is ambient temperature?
  8. Define the terms Honing and stropping.
  9. Write the composition and use of Mayer’s egg albumin.
  10. Name the endogenous and exogenous pigments present in the tissue sample.

 

SECTION-B

Answer any FOUR of the following:                                                          (4 X 10=40 Marks)

 

  1. Write short notes on different types of embedding media.
  2. Describe in detail the decalcification process with suitable example.
  3. How will you identify disulfide and indole group amino acids present in the tissue sample.
  4. Write short notes on problems encountered during section cutting.
  5. Write the principle, procedure and hitopathological importance of Sudan block B stain and

Toluidin blue stain.

  1. Give a brief account on the different types of microtome knife with suitable diagram.

SECTION-C

Answer any TWO of the following:                                                            (2 X 20=40 Marks)

 

  1. Describe the processing of histological tissues for paraffin embedding.
  2. Write in detail the different types of microtomes.
  3. Explain in detail the different staining methods involved in demonstration of nucleic acids.
  4. Give an account on the collection, processing and staining of cytological specimen.

 

 

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Loyola College M.Sc. Medical Lab Technology April 2008 Advanced Lab. Techniques Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LM 10

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

SECOND SEMESTER – APRIL 2008

    ML 2952 – ADVANCED LAB. TECHNIQUES

 

 

 

Date : 24/04/2008            Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION A

Answer ALL the questions:                                                            (10 x 2 = 20 Marks)

  1. What are the advantages of nucleic acid based identification methods?
  2. What is VNTR?
  3. Mention the characteristics of the different types of restriction endonucleases.
  4. What is homopolymer tailing?
  5. Define homologous chromosome.
  6. What is an allele?
  7. Define mutation.
  8. What is mosaicism?
  9. Mention the uses of DNA in forensic science.
  10. List the molecular techniques used in forensic investigation.

SECTION B

Answer any FOUR of the following                                             (4 x 10 = 40 Marks)

  1. Write briefly on gel electrophoresis.
  2. Give the difference between southern, northern and western blotting techniques.
  3. Write a brief account on plasmids.
  4. How is cell culture done for karyotyping? Explain.
  5. Write short notes on Prader Willi syndrome and Angelman syndrome.
  6. Give a brief account on DNA databases.

SECTION C

Answer any TWO of the following                                              (2 x 20 = 40 Marks)

  1. Write in detail about PCR technique.
  2. Explain in detail about the quality control and quality assurance in a molecular

diagnostic laboratory.

  1. Write in detail on structural chromosomal abnormalities.
  2. Explain in detail about Y chromosome analysis and Mitochondrial DNA analysis.

 

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Molecular Biology Question Paper PDF Download

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IB 13

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1809 – MOLECULAR BIOLOGY

 

 

 

Date : 08-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION –A

Answer ALL the following.                                                                                 (10 x 2 = 20 marks)

  1. Expand a) ASR b) CPT   c) ABCC   d) TWGDAM.
  2. What is RNA polymerase holoenzyme?
  3. Define chargaff’s rule of molar equivalence.
  4. Differentiate poly glutamine from non-poly glutamine disease.
  5. What are the clinical symptoms of xeroderma pigmentosum?
  6. Distinguish cisterns from crista.
  7. Define nucleic acid hybridization.
  8. Mention the role of catalase and oxidase in peroxisomes.
  9. What are the rare forms of sickle cell disease?
  10. Distinguish oncogenes from proto-oncogenes

 

SECTION – B

Answer any FOUR of the following.                                                                (4 x 10=40 marks)

  1. Explain the models of plasma membrane.
  2. Give an account on cytoskeleton, cilia, flagella and ribosome.
  3. Describe genetic code.
  4. Describe in detail the structure of DNA and the separation of strands.
  5. Give an account on the functional elements of chromosomes.
  6. Explain the translocation of mutation in Chronic myelogenous leukemia, Burkitt’s lymphoma and Wilm’s tumor.

 

SECTION – C

Answer any TWO of the following.                                                                  (2 x 20=40 marks)

  1. Explain the mechanism of replication.
  2. With a neat flow chart for establishing the molecular diagnostic laboratory, explain Laboratory design and Laboratory personnel.
  3. What are syndromes? Explain Duchenne muscular dystrophy and Prader – willi syndrome.
  4. Describe the types of gene mutations

 

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Pathogens Of Human Importance Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 20

M.Sc. DEGREE EXAMINATION – MEDICAL SOCIOLOGY

THIRD SEMESTER – November 2008

    ML 3902 – PATHOGENS OF HUMAN IMPORTANCE

 

 

 

Date : 14-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

PART-A

     ANSWER ALL THE QUESTIONS:                                          (10 x 2=20 Marks)

  1. Define the terms endemic, epidemic and pandemic.
  2. What is a communicable disease?
  3. Explain haemolytic uremic syndrome.
  4. Define the term pasteurization.
  5. Explain bacillary dysentery.
  6. Differentiate disinfectant from antiseptic.
  7. Distinguish bubonic from pneumonic plague.
  8. What are the common symptoms of typhoid?
  9. Define the terms cellulitis and pharyngitis.
  10. Write the names of the microorganisms which causes Diphtheria, Plague and Syphilis.

PART-B

    ANSWER ANY FOUR OF THE FOLLOWING:                    (4 X 10 =40 Marks)

  1. Write short notes on Trichomoniasis and Shigellosis.
  2. Explain the symptoms and complications of genital herpes.
  3. Write short notes on disinfectant and antiseptic.
  4. What is taeniasis? Explain the life cycle of taenia solium.
  5. What are the stages, signs and symptoms of whooping cough?
  6. Give an account of cycle for an infectious disease

PART-C

    ANSWER ANY TWO OF THE FOLLOWING:                        (2 X 20=40 Marks)

  1. Write in detail different types of sterilization methods.
  2. Explain the causes, symptoms, complications and lab diagnosis of typhoid fever.
  3. Describe in detail the life cycle and pathogenicity of malarial parasite.
  4. Write notes on Rabies and Poliomyelitis

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Pharmaceutical Chemistry And Toxicology Question Paper PDF Download

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IB 19

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

THIRD SEMESTER – November 2008

    ML 3875 – PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY

 

 

 

Date : 10-11-08                   Dept. No.                                          Max. : 100 Marks

Time : 9:00 – 12:00

Section A

Answer ALL the questions:                                                                                            (10 x 2 = 20 marks)

  1. Diethyl ether is a stronger hypnotic than acetone – Comment
  2. What is chelation? Give an example.
  3. What are the different effects caused by morphine in different species?
  4. Account for the antibacterial activity of aminoacridines.
  5. Mention the importance of organometallic compounds with examples.
  6. What are the units of radioactivity?
  7. Define pharmacodynamics.
  8. Mention the toxic effect of solvents.
  9. What are the three different types of interaction of toxic substances?
  10. Define renal clearance.

Section  B

Answer any FOUR of the following :                                                               (4 x 10 =40 marks)

  1. (a) What are preservatives and antioxidants? Give examples. (5)

(b) Explain therapeutic index and safety factor.                                                                           (5)

  1. Explain the correlation of antimicrobial activity with chelating property with suitable examples.
  2. What are pharmacodynamic agents? Discuss their classification.
  3. Write short notes on teratogens.
  4. Explain scintillation counter and Geiger Muller counter.
  5. Compare the biotransport process of drugs.

Section  C

Answer any TWO of the following:                                                                              (2 x 20 = 40 marks)

  1. (a) Explain (i) Labeling by isotope exchange. (ii) Labeling by irradiation by tritium.               (7)

(b)Discuss the effect of (a) isomerism (ii) Halogens (iii)aldehydes and ketones on the

activity of a drug.                                                                                                                                     (8)

(c) Explain any two types of ointment bases with examples.                                                       (5)

  1. (a) Discuss the classification of drugs involved in metabolic diseases and endocrine function.     ( 8)

(b) Explain the principles of NMR and X-ray diffraction technique used in the

characterization of drugs.                                                                                                                     (12)

  1. Explain the different methods of administering drugs into the body.
  2. Explain in detail radioimmunoassay.

 

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Statistical Applications In Biological Sciences Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

BA 28

M.Sc. DEGREE EXAMINATION – BIO.INST.SCI.& MED. LAB. TECHNOLOGY

THIRD SEMESTER – November 2008

           ST 3901 – STATISTICAL APPLICATIONS IN BIOLOGICAL SCIENCES

 

 

 

Date : 14-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

                                                         SECTION – A                                           (10 X 2 = 20 Marks )

                                                    

Answer ALL the Questions. Each Carries TWO marks.

 

  1. Distinguish between a statistic and a parameter.  Give an example for each.
  2. State any three properties of the arithmetic mean.
  3. The following are the serum lipid peroxide (SLP) values obtained from a sample of 10 apparently healthy adults :

4.07, 2.07, 3.64, 3.37, 3.84, 3.83, 3.82, 4.21, 4.04, 4.50.

For these data compute the mean, the variance and the standard deviation.

  1. What assumptions does one make when computing the following from grouped data?   (a) The mean (b) The median (c) The variance.
  2. What is the purpose of the coefficient of variation ?
  3. Explain linear and non-linear correlation.
  4. What is meant by multiple regression analysis ?
  5. Discuss about 95 % confidence interval.
  6. Write any three applications of the Chi – Square test.
  7. Define the variance ratio ( F ) and write the name of the sampling distribution of  F.

 

SECTION – B                                               (5 X 8 = 40 Marks )

 

Answer any FIVE  Questions. Each Carries EIGHT marks.

 

  1. The following are the fasting blood glucose levels of a sample of 10 children:

Value : 56, 62, 63, 65, 65, 65, 65, 68, 70, 72.

Compute ( a ) The mean ( b ) The median ( c ) The mode.

 

  1. The following table shows the age distribution of cases of a certain disease

reported during a year in a particular state.

 

Age                : 5-14   15-24   25-34   35-44   45-54   55-64

No. of cases   :   5          10         20        22         13        5

Compute the mean and standard deviation.

 

  1. Describe the scatter diagram method of studying correlation with illustrations.

 

  1. For the following data on RNA content  ( X ) of cells and rate of protein synthesis ( Y ), calculate regression equation of Y on X.

 

RNA content (mg/100ml)        :    40    45    48    54    66    78    86    90

Protein Synthesis rate (mg/hr) :    5.0   5.8   6.4   7.2   7.5   7.8   8.2   9.0

 

  1. In a survey on hearing level of school children with normal hearing it was found that in the frequency 500 cycles per second, 62 children tested in the sound proof room had a mean hearing threshold of 15.5 decibels with a standard deviation of 6.5.  76 comparable children who were tested in the fields had mean threshold of 20.0 decibels with a standard deviation of 7.1. Test if there is any difference between the hearing levels recorded in the sound proof room and in the field.

 

  1. The severity of a disease and blood type were studied. The findings are given

in the following table :

 

Severity Blood group
O Others
Yes 51 59
No 489 901

 

Test for the independence of the blood groups and the severity of the disease.

 

  1. State the assumptions of ANOVA.

 

  1.  Calculate the rank correlation coefficient from the following data :

 

Price of Tea     ( Rs.) :       75     88     95     70     60     80     81     50

Price of Coffee( Rs.) :     100   134   150   115    110  140    142   100

 

 

SECTION – C                                              ( 2 X 20 = 40 Marks )

 

       Answer any TWO  Questions. Each Carries TWENTY marks.

 

  1. The following table shows the number of hours 45 hospital patients slept

following the administration of a certain anesthetic.

 

7 10 12 4 8 7 3 8 5
12 11 3 8 1 1 13 10 4
4 5 5 8 7 7 3 2 3
8 13 1 7 17 3 4 5 5
3 1 17 10 4 7 7 11 8

 

From these data construct :

( a ) A frequency distribution.

( b ) A relative frequency distribution.

( c ) A histogram.

( d ) A frequency polygon.

 

  1. ( a ). The first four central moments of a distribution are 0, 2.5, 0.7 and 18.75.

Test the skewness and kurtosis of the distribution.                                                                    ( 5 )

 

( b ). Calculate Kelly’s Coefficient of skewness from the following positional

measures given below :

P90  =  205,     P10  =  25,     P50   =  150                                                                   ( 5 )

 

( c ). Calculate Karl Pearson’s coefficient of correlation for the following data

on length  in cm ( X ) and weight in gm ( Y ) of a species of aquarium

fish.

X   :    3       7        12       15      20       25      30

Y   :    5      10       15       20      25       30      35                                                               ( 10 )

 

  1. A health status survey in a few villages revealed that the normal serum

protein value of children in that locality is 7.0 g / 100 ml. A group of 16

children who received high protein food for a period of six months had serum

protein values shown below. Can we consider that the mean serum protein

level of those who were fed on  high protein diet is different from that of the

general  population ?

 

Protein Level ( g % )  7.10, 7.70, 8.20, 7.56, 7.05, 7.08,  7.21 , 7.25, 7.36,

 

6.59, 6.85, 7.90, 7.27, 6.56, 7.93, 8.56 .

 

  1. The haemoglobin levels of three groups of children fed on three different

are given below. Test whether the means of these three groups differ

significantly.

Haemoglobin levels ( g % )

 

Group I            Group II           Group III

 

11.6                  11.2                  9.8

10.3                    8.9                  9.7

10.0                    9.2                 11.5

11.5                    8.8                 11.6

11.8                    8.4                 10.8

11.8                    9.1                   9.1

12.1                    6.3                 10.5

10.8                    9.3                 10.0

11.9                    7.8                 12.4

10.7                    8.8                 10.7

11.5                      10.0

9.7

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Medical Transcription Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 15

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1952 – MEDICAL TRANSCRIPTION

 

 

 

Date : 11-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

SECTION-A

Answer ALL the questions                                                                          10 x 2 =20 marks

  1. Comment on catheterization.
  2. What is hypertension?
  3. What are hormones?
  4. What is complete blood count?
  5. Define appendicitis.
  6. What is metabolism?
  7. Define myocardial infarction.
  8. Differentiate bradycardia from tachycardia.
  9. Define respiration.
  10. Define laparoscopy?

SECTION-B

Answer any FOUR of the following                                                4 x 10=40 marks

  1. Write a short notes on basic elements of medical terminology.
  2. Explain functions and clinical features of human cardiac system with a neat labeled diagram
  3. Give an account on basic rules and steps for defining medical words with examples.
  4. Write short notes on structure, and laboratory procedures involved in skeletal system.
  5. Give an account on transcription steps involved in MT.
  6. Write short notes on structure and laboratory procedures involved in ophthalmology.

SECTION –C

Answer any TWO of the following                                     2X20=40 marks.

  1. Describe various components of pharmacology involved in medical transcription.
  2. Explain the structure, functions, clinical features and laboratory procedures involved in nervous system.
  3. Describe the structure, functions, clinical features and laboratory procedures involved in endocrine glands.
  4. Discuss parts of speech, subject- verb agreement, tense, and punctuation in detail.

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Human Physiology Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 17

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

THIRD SEMESTER – November 2008

    ML 3801 – HUMAN PHYSIOLOGY

 

 

 

Date : 05-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

SECTION –A

Answer ALL the following.                                                                                 10 x 2 =20 marks

  1. What is haem-haem interaction?
  2. Distinguish sensory nerves from motor nerves in brain.
  3. Mention the role played by oxytocin hormone in females.
  4. List the epidermal layers of skin.
  5. Define goiter. Mention its types.
  6. What are the lobes that are present in cerebral cortex?
  7. What is micturition reflex?
  8. List the functions of the lymphatic system.
  9. Categorize the cells in anterior pituitary based on their secretary nature.
  10. List down the types of muscles.

 

SECTION B

Answer any four of the following.                                                       4 x 10=40 marks

  1. With the neat sketch of gastric gland, explain the constituents of gastric juice.
  2. Draw and explain the structure and function of hair follicle.
  3. Describe the actions and abnormalities of pancreatic hormones.
  4. Give an account on micturition.
  5. Explain the pulmonary volumes and capacities with diagram.
  6. Draw and explain the structure and function of spinal cord.

 

SECTION-C

 

Answer any TWO of the following.                                                      2 x 20=40 marks

  1. Define absorption and explain the absorption of carbohydrates, lipids, electrolytes and Water.
  2. Draw and explain the flow of blood and conduction system of the heart.
  3. Draw the structure of thyroid gland and describe the secretion, synthesis and abnormalities of thyroid hormones.
  4. Explain the stages of oogenesis and phases of ovarian cycle with neat diagrams.

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Hospital Management Question Paper PDF Download

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IB 14

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1951 – HOSPITAL MANAGEMENT

 

 

 

Date : 11-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

Section A

Answer ALL the questions:                                                                                            (10 x 2 = 20 marks)

  1. List the data essential for planning a hospital.
  2. What are the objectives of outpatient service?
  3. Mention the types of wards.
  4. What are the records to be maintained in a blood bank?
  5. What is a medical record?
  6. List the factors that promote quality assurance.
  7. Define public.
  8. What is recruitment?
  9. Define inventory.
  10. What are the three types of accounts in transaction?

 

Section  B

Answer any FOUR of the following :                                                               (4 x 10 =40 marks)

 

  1. Explain the different diagnostic laboratories in a hospital.
  2. What are the procedures to be followed before accepting and issuing blood.
  3. Give the general classification of diseases.
  4. What are the factors affecting hospital expenditure?
  5. Explain the four basic steps in training.
  6. Write briefly on storekeeping and warehousing.

 

Section  C

Answer any TWO of the following:                                                                              (2 x 20 =40 marks)

  1. Explain the responsibilities of the hospital administrator.
  2. Write in detail on hospital waste management.
  3. Explain the importance and maintenance of hospital records.
  4. Write in detail the organization of OP and IP ward.

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Haematology Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 11

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1806 – HAEMATOLOGY

 

 

 

Date : 04-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

Section-A

Answer ALL the questions                                                         2X10=20 marks

  1. Differentiate granulopoiesis from agranulopoiesis.
  2. Define Von Willebrands disease?
  3. What is folic acid anaemia?
  4. Mention the functions of thrombocytes.
  5. What is haemostasis?
  6. Write the composition of Hayem’s and Turck’s diluting fluid?
  7. What are anticoagulants?
  8. What is DIC?
  9. Comment on PAS test.
  10. What are cytochemical tests?

 

Section-B

Answer any FOUR of the following                                         4X10=40 marks

  1. Write short notes on haematopoiesis with a neat labelled flow chart.
  2. Describe briefly red cell indices. What are the causes and symptoms of anaemia?
  3. Describe briefly the principle and clinical significance of differential count.
  4. Write the principle and clinical significance of haemoglobin estimation.
  5. Write short notes on any two human blood parasites.
  6. Discuss briefly the principle and procedure for reticulocyte count.

 

Section –C

Answer any TWO of the following                                           2X20=40 marks.

  1. Explain the principle and procedure for leucocyte and erythrocyte count. Add a note on

clinical significance.

18 Discuss the principle and procedure for LE cell preparation and Heinz Body preparation test.

  1. Explain the principle and clinical significance of eosinophil count. Give an account on

principle and procedure for platelet count.

  1. Give an account on Quality Control and Quality Assessment programs

 

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Fluid Analysis Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 16

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

THIRD SEMESTER – November 2008

    ML 3800 – FLUID ANALYSIS

 

 

 

Date : 03-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 9:00 – 12:00

SECTION A

Answer ALL the questions:                                                                                (10 x 2 = 20)

  1. Define effusion.
  2. What are the two layers present in the serous membrane?
  3. What is anencephaly?
  4. APT test.
  5. What are charcots joints?
  6. What is SLE?
  7. Mention the crystals present in synovial fluid.
  8. Classify the different types of synovial joints.
  9. Draw the distal end of the vertebral column.
  10. What is multiple sclerosis?

 

SECTION  B

Answer any FOUR of the following :                                                           (4 x 10 =40)

  1. Write a short note on measurement of body fluid volumes.
  2. What are the different body fluid compartments. Add a note on each.
  3. Give the normal and abnormal findings of amniotic fluid analysis.
  4. What is osteoarthritis. Explain its types.
  5. Write short notes on the diseases of the brain.
  6. Define clearance. Write briefly on renal clearance tests.

 

SECTION  C

Answer any TWO of the following:                                                                  (2 x 20 =40)

  1. Explain amniocentesis. Explain the parameters used to study fetal lung maturity.
  2. Define synovial fluid. Give the composition and classification of synovial fluid and add a note on its analysis.
  3. Explain the formation and circulation of CSF. Write briefly on lumbar puncture.
  4. Write in detail on the structure of a nephron and formation of urine.

 

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Loyola College M.Sc. Medical Lab Technology Nov 2008 Clinical Biochemistry Question Paper PDF Download

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

IB 12

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FIRST SEMESTER – November 2008

    ML 1808 – CLINICAL BIOCHEMISTRY

 

 

 

Date : 06-11-08                 Dept. No.                                        Max. : 100 Marks

Time : 1:00 – 4:00

PART-A

ANSWER ALL THE QUESTIONS:                                             (10 x 2=20 Marks)

  1. Draw the symbol of bio and radiation hazards
  2. What is Beer’s and Lambert’s law?
  3. What are non-protein nitrogenous substances?
  4. What is prostate specific antigen?
  5. Name the anti-sterility and anti-pernicious vitamins.
  6. What is sodium potassium ATPase?
  7. Define the term haemostasis?
  8. What is fructosuria?
  9. Write the normal values of SGOT, SGPT,ALP and LDH.
  10. What is Achlorhydria?

PART-B

ANSWER ANY FOUR OF THE FOLLOWING:                      (4 x 10 =40 Marks)

  1. Describe in detail the TCA cycle.
  2. What is buffer?Explain blood buffer system.
  3. Describe the sources, biological functions and deficiency manifestation of Vitamin A.
  4. Write about types, characteristics and functions of lipoproteins.
  5. Write short notes on cardiac marker enzymes.
  6. Enumerate various functions of the liver and add a note on galactose tolerance test

 

PART-C

ANSWER ANY TWO OF THE FOLLOWING:                          (2 x 20=40 Marks)

  1. Discuss the cascade of blood clotting process.
  2. Classify vitamins and briefly discuss their function and deficiency disorders of fat soluble vitamins.
  3. Describe in detail the liver function test.
  4. Describe in detail the renal and respiratory mechanisms of acid base balance

 

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Loyola College M.Sc. Medical Lab Technology April 2009 Separation Techniques Question Paper PDF Download

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     LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB TECHNOLOGY

VE 36

SECOND SEMESTER – April 2009

BT 2900 – SEPARATION TECHNIQUES

 

 

 

Date & Time: 29/04/2009 / 1:00 – 4:00  Dept. No.                                                    Max. : 100 Marks

 

 

SECTION – A

Answer all the questions                     (20 marks)

 

  1. Choose the best answer. (5 x 1 = 5)

 

  1. Each molecule of SDS approximately binds to how many amino acids in the polypeptide chain?
  2. a) one         b) two              c) three            d) four
  3. The time taken for hybridization when a UV crosslinker is used is
  4. a) 2 sec        b) 20 sec          c) 2 min           d) 20 min
  5. Xylene cyanol migrates at the rate of which size of DNA fragment?
  6. a) 300 bp b) 3000 bp       c) 400  bp        d) 4000 bp
  7. In Rocket immunoelectrophoresis, the antibody is added to the
  8. a) agarose b) well             c) ethidium bromide    d) electrophoretic tank
  9. Which of the following does not affect the separating molecules in chromatography?
  10. a) surface adsorption b) relative solubility  c) charge   d) isoelectric point

 

  1. Say True or False; if false, state reasons. (5 x 1 = 5)

 

  1. Gravity force is an example of propelling force in chromatography.
  2. Science published Taq polymerase as the molecule of the year in 1989.
  3. Stoke’s law deals with the sedimentation of a rigid non-spherical particle.
  4. The breaking of larger DNA fragments into smaller ones is called depurination.
  5. Avidin-biotin is the strongest known protein-protein interaction.

 

III. Complete the following.                                                                (5 x 1 = 5)

 

  1. ________ discovered the concept of PCR.
  2. Ammonium chloride is used for the selective lysis of ______.
  3. The commonly used gradients for centrifugation are _______ and _______.
  4. ________ is an example of anionic exchanger.
  5. ___________ is added in denaturing gels used for RNA separarion.

 

  1. Answer the following in one or two sentences, each in about 50 words. (5 x 1 =5)

 

  1. Partition coefficient
  2. rpm value
  3. Swinging bucket rotors
  4. DEPC
  5. Ouchterlony

 

 

 

 

 

 

SECTION – B

  1. Answer any five questions, each in about 350 words only. (5 x 8 = 40)

 

  1. How would you isolate the plasmids from a given bacterial culture using alkaline

lysis method? Explain with the principle and protocol.

  1. What do you know about multiplexing PCR? What are its advantages?
  2. Differentiate between the use of nitrocellulose and nylon membranes used for

Southern blotting. List the steps involved in the same.

  1. What are the basic steps involved in RNA isolation? Write the methodology of RNA

extraction using Trizol reagent.

  1. How will you interpret the differing precipitin patterns obtained in ODD test?
  2. Write about the isolation of DNA from a given plant source.
  3. Explain the principle and procedure involved in Immunoelectrophoresis.
  4. What do you know about the instrumentation of HPLC.

 

SECTION – C

  1. Answer the following, each in about 1500 words. (2 x 20 = 40)

 

 

  1. a) (i) Give a brief account on paper chromatography, focusing upon the forces that aid

separation of compounds. (10)

(ii) How is TLC superior over paper chromatography? (4)

      (iii) Explain the principle of size-exclusion chromatography? (6)

     

.

(or)

 

  1. b) What is the principle of using agarose gel for nucleic acid separation? Enumerate

the steps involved in separating DNA molecules using agarose gel electrophoresis.

Add a note on the various factors that affect the mobility of DNA fragments in the

agarose gel.(6 + 8 + 6)

 

  1. a) (i) What are the different sources from which you can get protoplasts? (5)

(ii) Give an account on the mechanical method of protoplast isolation. (5)

(iii) What are the enzymes required for protoplast isolation? How will you isolate the

protoplasts using these enzymes? (4 + 6)

   

(or)

 

  1. b) Write an essay on the modifications of PCR and its specific applications.

 

 

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Loyola College M.Sc. Medical Lab Technology April 2009 Pathogens Of Human Importance Question Paper PDF Download

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      LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

BV 14

THIRD SEMESTER – April 2009

ML 3902 – PATHOGENS OF HUMAN IMPORTANCE

 

 

 

Date & Time: 29/04/2009 / 9:00 – 12:00     Dept. No.                                                       Max. : 100 Marks

 

 

PART-A

ANSWER ALL THE QUESTIONS:                                      (10 x 2=20 Marks)

  1. What are antigen and antibody?
  2. Explain infectious disease with example.
  3. What is opportunistic pathogen?
  4. Define the term bacteremia and septicemia.
  5. Draw neat labeled diagram of HIV.
  6. Distinguish food intoxication from food poisoning
  7. Expand MMR and DPT.
  8. What is MDR-Tuberculosis?
  9. Distinguish Red measles from German measles.
  10. What is trichomoniasis?

 

PART-B

ANSWER ANY FOUR OF THE FOLLOWING:              (4 x 10 =40 Marks)

  1. Describe in detail the pre and post streptococcal infection.
  2. Describe in detail the three phases of lymphogranuloma venereum.
  3. Explain the life cycle and pathogenicity of Entamoeba histolytica.
  4. Write short notes on different types of jaundice.
  5. Explain the exo and endoerythrocytic cycle of malarial parasite.
  6. Explain the causes, pathogenicity and lab diagnosis of gastroenteritis.

 

PART-C

ANSWER ANY TWO OF THE FOLLOWING:                (2 x 20=40 Marks)

  1. Describe in detail the HIV infection.
  2. Describe the four types of modes of transmission of infectious diseases with examples.
  3. Explain the pathogenicity,symptoms and lab diagnosis of TB.
  4. Write in detail the different types of sterilization methods.

 

 

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Loyola College M.Sc. Medical Lab Technology April 2009 Non-Invasive Techniques Question Paper PDF Download

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    LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

BU 16

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

FOURTH SEMESTER – April 2009

ML 4801 – NON-INVASIVE TECHNIQUES

 

 

Date & Time: 18/04/2009 / 9:00 – 12:00       Dept. No.                                                        Max. : 100 Marks

 

SECTION –A

Answer ALL the following.                                                                                        (2×10=20 marks)

  1. What is thermionic emission?
  2. Draw and mention the types of magnets.
  3. Define deuteranopia and achromatopsia.
  4. What is the use of applying electrode paste before performing any technique?
  5. Differentiate ionizing from non-ionizing radiation.
  6. What are Wet macular degeneration and Dry macular degeneration.
  7. Mention the normal phases in fluorescein angiography.
  8. Define retinopathy. List the different types of retinopathy.
  9. Comment on fibro adenoma and Duct pappiloma
  10. Expand a.) OPPG   b.) VAT   c.) CRVO  d.) ARMD

 

SECTION B

Answer any FOUR of the following.                                                                                     (4×10=40 marks)

  1. Explain the principle, procedure and patient preparation to take an x-ray.
  2. Give an account on transcranial doppler studies
  1. Describe the principle, procedure for single photon emission computed

 

  1. Explain the principle and clinical findings of fluorescein angiography.
  2. Describe the interpretations of normal and abnormal electrocardiography.
  3. Explain the procedure, advantages and disadvantages of opthalmoscopy.

                                                                  SECTION-C

Answer any TWO of the following.                                                                                     (2×20=40 marks)

  1. Give an account on principle, procedure, advantages and limitations of positron emission

tomography.

 

  1. Describe the modes of examination of an ultrasound.
  1. Explain the procedure, findings, interpretation and importance of electroencephalography.

 

  1. Describe the principle, procedure, types of scanning systems and types of computed tomography.

 

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Loyola College M.Sc. Medical Lab Technology April 2009 Molecular Biology Question Paper PDF Download

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        LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

M.Sc. DEGREE EXAMINATION – MEDICAL LAB. TECH.

BV 03

FIRST SEMESTER – April 2009

ML 1809 – MOLECULAR BIOLOGY

 

 

 

Date & Time: 28/04/2009 / 1:00 – 4:00  Dept. No.                                                   Max. : 100 Marks

 

 

 

SECTION –A

Answer ALL the following.                                                                     10 x 2 =20 marks

  1. Draw the structure of nucleus and add a note on it.
  2. Expand a) FDA b) CLIA  c) ASCLD  d) CDC.
  3. What is the difference between prader – willi syndrome and angelman syndrome?
  4. List the different classes of Oncogene.
  5. Mention the role played by CFTR in human body.
  6. Write the difference between rho-dependent and rho-independent terminators.
  7. Write the original wobble predictions.
  8. Define mutagen.
  9. Mention the role played by DNA unwinding proteins
  10. What are types of euploidy?

SECTION B

Answer any FOUR of the following.                                                    4 x 10=40 marks

  1. Explain the structure and function of RNA.
  2. Describe cystic fibrosis in detail.
  3. Explain the forensic identity testing by DNA analysis.
  4. Describe the four rules that govern the synthesis of bio-polymers with illustrations.
  5. Give an account on Sickle cell anaemia.
  6. Describe the three common DNA excision repair mechanisms in our body.

 

SECTION-C

Answer any TWO of the following.                                                      2 x 20=40 marks

  1. Explain the mechanism of translation.
  2. Describe the translocation of mutations in various types of cancer
  3. Draw the structure of eukaryotic cell and explain a) Golgi bodies b) Mitochondria

c)Lysosomes

  1. Explain the morphology and functional elements of eukaryotic chromosomes

 

 

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